Motif ID: ZNF524

Z-value: 1.715


Transcription factors associated with ZNF524:

Gene SymbolEntrez IDGene Name
ZNF524 ENSG00000171443.6 ZNF524

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF524hg19_v2_chr19_+_56111680_561117350.377.3e-02Click!


Activity profile for motif ZNF524.

activity profile for motif ZNF524


Sorted Z-values histogram for motif ZNF524

Sorted Z-values for motif ZNF524



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF524

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 9.975 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr19_+_35645817 9.208 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr19_+_35645618 7.532 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr19_-_51487071 7.071 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr19_+_8429031 6.191 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
 ANGPTL4


angiopoietin-like 4


chr11_-_66725837 6.128 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
 PC



pyruvate carboxylase



chr12_+_8975061 5.772 ENST00000299698.7
 A2ML1
alpha-2-macroglobulin-like 1
chr20_+_30327063 5.316 ENST00000300403.6
ENST00000340513.4
 TPX2

TPX2, microtubule-associated

chr19_-_11266471 4.601 ENST00000592540.1
 SPC24
SPC24, NDC80 kinetochore complex component
chr19_-_15343191 4.435 ENST00000221730.3
 EPHX3
epoxide hydrolase 3
chr13_-_20806440 4.055 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr12_-_76425368 3.915 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr19_-_51504852 3.912 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr22_+_30792846 3.784 ENST00000312932.9
ENST00000428195.1
 SEC14L2

SEC14-like 2 (S. cerevisiae)

chr19_-_55658281 3.729 ENST00000585321.2
ENST00000587465.2
 TNNT1

troponin T type 1 (skeletal, slow)

chr2_+_64681103 3.718 ENST00000464281.1
 LGALSL
lectin, galactoside-binding-like
chr17_+_7942424 3.682 ENST00000573359.1
 ALOX15B
arachidonate 15-lipoxygenase, type B
chr4_-_80994471 3.654 ENST00000295465.4
 ANTXR2
anthrax toxin receptor 2
chr6_+_86159821 3.568 ENST00000369651.3
 NT5E
5'-nucleotidase, ecto (CD73)
chr19_-_15343773 3.516 ENST00000435261.1
ENST00000594042.1
 EPHX3

epoxide hydrolase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 481 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 17.0 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
5.6 16.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.2 9.9 GO:1901998 toxin transport(GO:1901998)
0.9 8.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.4 7.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.0 7.0 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 7.0 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
1.7 6.8 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 6.5 GO:0007062 sister chromatid cohesion(GO:0007062)
0.1 6.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.6 6.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
1.9 5.8 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 5.6 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.5 4.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.5 4.9 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 4.6 GO:0051382 kinetochore assembly(GO:0051382)
0.2 4.6 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 4.4 GO:0097435 fibril organization(GO:0097435)
0.4 4.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
1.3 3.9 GO:0045210 FasL biosynthetic process(GO:0045210)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 17.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 14.1 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.4 8.6 GO:0005861 troponin complex(GO:0005861)
1.3 7.9 GO:0031262 Ndc80 complex(GO:0031262)
0.0 7.6 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 7.4 GO:0072562 blood microparticle(GO:0072562)
0.0 6.1 GO:0005882 intermediate filament(GO:0005882)
0.0 6.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 5.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.7 5.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 5.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 5.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 5.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.4 4.6 GO:0043203 axon hillock(GO:0043203)
0.5 4.3 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.2 4.0 GO:0005922 connexon complex(GO:0005922)
0.0 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 3.8 GO:0071438 invadopodium membrane(GO:0071438)
0.5 3.6 GO:0005610 laminin-5 complex(GO:0005610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 333 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 16.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 9.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 9.0 GO:0008236 serine-type peptidase activity(GO:0008236)
0.6 8.3 GO:0031014 troponin T binding(GO:0031014)
0.4 7.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 7.7 GO:0005096 GTPase activator activity(GO:0005096)
2.3 7.0 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
1.6 6.4 GO:0008431 vitamin E binding(GO:0008431)
0.6 6.1 GO:0004075 biotin carboxylase activity(GO:0004075)
1.1 5.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.5 4.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.5 4.9 GO:0043426 MRF binding(GO:0043426)
0.0 4.9 GO:0005125 cytokine activity(GO:0005125)
0.0 4.7 GO:0044325 ion channel binding(GO:0044325)
0.7 4.3 GO:0043515 kinetochore binding(GO:0043515)
0.2 4.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 4.2 GO:0005178 integrin binding(GO:0005178)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
0.0 4.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 11.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 8.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 8.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 7.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 7.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 4.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 4.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 4.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 3.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 3.0 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.9 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 11.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 7.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4 7.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 7.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 6.3 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 4.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 4.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 3.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 3.8 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 3.3 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 3.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 3.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)