Motif ID: ZNF711_TFAP2A_TFAP2D

Z-value: 1.947

Transcription factors associated with ZNF711_TFAP2A_TFAP2D:

Gene SymbolEntrez IDGene Name
TFAP2A ENSG00000137203.6 TFAP2A
TFAP2D ENSG00000008197.4 TFAP2D
ZNF711 ENSG00000147180.12 ZNF711

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF711hg19_v2_chrX_+_84498989_84499003,
hg19_v2_chrX_+_84499038_84499078		-0.472.1e-02Click!
TFAP2Dhg19_v2_chr6_+_50681541_50681541-0.462.3e-02Click!
TFAP2Ahg19_v2_chr6_-_10415470_10415508-0.433.4e-02Click!


Activity profile for motif ZNF711_TFAP2A_TFAP2D.

activity profile for motif ZNF711_TFAP2A_TFAP2D


Sorted Z-values histogram for motif ZNF711_TFAP2A_TFAP2D

Sorted Z-values for motif ZNF711_TFAP2A_TFAP2D



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF711_TFAP2A_TFAP2D

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_7044657 9.228 ENST00000310085.4
 CCDC96
coiled-coil domain containing 96
chr5_-_180018540 9.217 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr12_+_50355647 8.841 ENST00000293599.6
 AQP5
aquaporin 5
chr21_-_43916433 6.230 ENST00000291536.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr22_-_50970506 6.145 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr21_+_36041688 5.925 ENST00000360731.3
ENST00000349499.2
 CLIC6

chloride intracellular channel 6

chr2_-_130902567 5.675 ENST00000457413.1
ENST00000392984.3
ENST00000409128.1
ENST00000441670.1
ENST00000409943.3
ENST00000409234.3
ENST00000310463.6
 CCDC74B






coiled-coil domain containing 74B






chr14_+_105953204 5.560 ENST00000409393.2
 CRIP1
cysteine-rich protein 1 (intestinal)
chr5_+_10441970 5.379 ENST00000274134.4
 ROPN1L
rhophilin associated tail protein 1-like
chr4_-_16085340 5.365 ENST00000508167.1
 PROM1
prominin 1
chr11_+_94245617 5.342 ENST00000542198.1
 RP11-867G2.2
long intergenic non-protein coding RNA 1171
chr6_-_33048483 4.783 ENST00000419277.1
 HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_+_132285406 4.690 ENST00000295171.6
ENST00000409856.3
 CCDC74A

coiled-coil domain containing 74A

chr10_+_22634384 4.673 ENST00000376624.3
ENST00000376603.2
ENST00000376601.1
ENST00000538630.1
ENST00000456231.2
ENST00000313311.6
ENST00000435326.1
 SPAG6






sperm associated antigen 6






chr2_-_239148599 4.627 ENST00000409182.1
ENST00000409002.3
ENST00000450098.1
ENST00000409356.1
ENST00000409160.3
ENST00000409574.1
ENST00000272937.5
 HES6






hes family bHLH transcription factor 6






chr7_-_131241361 4.584 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like



chr14_+_105953246 4.556 ENST00000392531.3
 CRIP1
cysteine-rich protein 1 (intestinal)
chr3_-_197686847 4.424 ENST00000265239.6
 IQCG
IQ motif containing G
chr5_+_76506706 4.417 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr3_-_158450475 4.389 ENST00000237696.5
 RARRES1
retinoic acid receptor responder (tazarotene induced) 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 43.4 GO:0060271 cilium morphogenesis(GO:0060271)
1.1 38.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.5 26.9 GO:0042073 intraciliary transport(GO:0042073)
0.1 20.9 GO:0000209 protein polyubiquitination(GO:0000209)
0.8 18.4 GO:0035082 axoneme assembly(GO:0035082)
3.4 17.0 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.7 14.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.8 13.9 GO:0003351 epithelial cilium movement(GO:0003351)
3.5 13.8 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
1.1 12.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.6 12.2 GO:0003341 cilium movement(GO:0003341)
0.9 12.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 11.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.4 9.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 8.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 8.6 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.2 8.4 GO:0033572 transferrin transport(GO:0033572)
0.1 8.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.3 8.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.5 7.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 429 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 40.0 GO:0005654 nucleoplasm(GO:0005654)
0.4 31.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
1.1 21.2 GO:0036038 MKS complex(GO:0036038)
0.2 16.6 GO:0036064 ciliary basal body(GO:0036064)
1.1 16.0 GO:0001520 outer dense fiber(GO:0001520)
0.0 15.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.4 14.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 13.2 GO:0031514 motile cilium(GO:0031514)
0.6 12.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 12.1 GO:0009925 basal plasma membrane(GO:0009925)
0.2 11.5 GO:0005801 cis-Golgi network(GO:0005801)
0.1 11.3 GO:0016605 PML body(GO:0016605)
0.5 11.2 GO:0030992 intraciliary transport particle B(GO:0030992)
1.0 10.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.4 9.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.8 8.8 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.1 8.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.5 8.6 GO:0000124 SAGA complex(GO:0000124)
0.1 8.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 8.3 GO:0032592 integral component of mitochondrial membrane(GO:0032592)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 722 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 59.5 GO:0003677 DNA binding(GO:0003677)
0.1 33.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 16.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 15.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.7 14.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.7 11.8 GO:0003680 AT DNA binding(GO:0003680)
0.2 11.1 GO:0042805 actinin binding(GO:0042805)
0.8 10.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.3 10.1 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 8.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 8.4 GO:0050811 GABA receptor binding(GO:0050811)
0.3 8.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 8.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 8.0 GO:0030544 Hsp70 protein binding(GO:0030544)
2.5 7.5 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.9 7.5 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.2 7.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
1.1 7.4 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 7.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 7.2 GO:0015250 water channel activity(GO:0015250)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 12.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 11.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 10.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 9.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 7.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 7.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 7.0 PID_MYC_PATHWAY C-MYC pathway
0.1 6.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 6.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 6.2 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.1 5.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 5.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 5.3 PID_ALK2_PATHWAY ALK2 signaling events
0.2 5.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 35.2 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 11.9 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.2 11.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 11.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.7 11.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 10.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 9.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 9.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 9.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.3 8.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.4 8.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 7.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 7.9 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 7.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 7.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 6.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 6.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.4 6.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 6.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 5.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis