Motif ID: ZNF740_ZNF219

Z-value: 0.720

Transcription factors associated with ZNF740_ZNF219:

Gene SymbolEntrez IDGene Name
ZNF219 ENSG00000165804.11 ZNF219
ZNF740 ENSG00000139651.9 ZNF740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF740hg19_v2_chr12_+_53574464_535745390.443.2e-02Click!
ZNF219hg19_v2_chr14_-_21566731_21566836,
hg19_v2_chr14_-_21567009_21567173		-0.154.8e-01Click!


Activity profile for motif ZNF740_ZNF219.

activity profile for motif ZNF740_ZNF219


Sorted Z-values histogram for motif ZNF740_ZNF219

Sorted Z-values for motif ZNF740_ZNF219



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF740_ZNF219

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_43239191 1.287 ENST00000589230.1
 HEXIM2
hexamethylene bis-acetamide inducible 2
chr17_+_55333876 1.166 ENST00000284073.2
 MSI2
musashi RNA-binding protein 2
chr9_-_20622478 1.066 ENST00000355930.6
ENST00000380338.4
 MLLT3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr17_+_43238438 1.034 ENST00000593138.1
ENST00000586681.1
 HEXIM2

hexamethylene bis-acetamide inducible 2

chr1_+_164528866 0.896 ENST00000420696.2
 PBX1
pre-B-cell leukemia homeobox 1
chr10_+_99344071 0.857 ENST00000370647.4
ENST00000370646.4
 HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

chr5_-_146833485 0.804 ENST00000398514.3
 DPYSL3
dihydropyrimidinase-like 3
chr2_+_148778570 0.780 ENST00000407073.1
 MBD5
methyl-CpG binding domain protein 5
chr8_+_75896731 0.751 ENST00000262207.4
 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr6_+_17281573 0.712 ENST00000379052.5
 RBM24
RNA binding motif protein 24
chr4_-_168155730 0.708 ENST00000502330.1
ENST00000357154.3
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr5_-_146833222 0.700 ENST00000534907.1
 DPYSL3
dihydropyrimidinase-like 3
chr9_-_124991124 0.696 ENST00000394319.4
ENST00000340587.3
 LHX6

LIM homeobox 6

chr14_-_61190754 0.692 ENST00000216513.4
 SIX4
SIX homeobox 4
chr2_-_148779106 0.685 ENST00000416719.1
ENST00000264169.2
 ORC4

origin recognition complex, subunit 4

chr15_+_71145578 0.684 ENST00000544974.2
ENST00000558546.1
 LRRC49

leucine rich repeat containing 49

chr17_-_56065484 0.681 ENST00000581208.1
 VEZF1
vascular endothelial zinc finger 1
chr3_-_197676740 0.649 ENST00000452735.1
ENST00000453254.1
ENST00000455191.1
 IQCG


IQ motif containing G


chr7_+_73442487 0.639 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
 ELN










elastin










chr17_+_42634844 0.634 ENST00000315323.3
 FZD2
frizzled family receptor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.7 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.6 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 1.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.3 GO:0008542 visual learning(GO:0008542)
0.1 1.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.0 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.3 0.9 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.8 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.8 GO:0007288 sperm axoneme assembly(GO:0007288)
0.2 0.7 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.7 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 0.6 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.5 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.1 0.5 GO:1902613 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0071953 elastic fiber(GO:0071953)
0.1 1.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 1.5 GO:0031941 filamentous actin(GO:0031941)
0.0 1.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 1.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.2 0.6 GO:0031213 RSF complex(GO:0031213)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.0 0.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.4 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.0 GO:0019213 deacetylase activity(GO:0019213)
0.1 1.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.8 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.5 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 0.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.8 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis