Motif ID: ZNF8

Z-value: 0.300


Transcription factors associated with ZNF8:

Gene SymbolEntrez IDGene Name
ZNF8 ENSG00000083842.8 ZNF8
ZNF8 ENSG00000273439.1 ZNF8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_587903580.154.9e-01Click!


Activity profile for motif ZNF8.

activity profile for motif ZNF8


Sorted Z-values histogram for motif ZNF8

Sorted Z-values for motif ZNF8



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_13043697 0.675 ENST00000378825.3
 CCDC3
coiled-coil domain containing 3
chr6_+_88117683 0.430 ENST00000369562.4
 C6ORF165
UPF0704 protein C6orf165
chr6_+_29691198 0.323 ENST00000440587.2
ENST00000434407.2
 HLA-F

major histocompatibility complex, class I, F

chr6_+_29691056 0.321 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
 HLA-F


major histocompatibility complex, class I, F


chr6_-_26056695 0.259 ENST00000343677.2
 HIST1H1C
histone cluster 1, H1c
chr4_+_186347388 0.252 ENST00000511138.1
ENST00000511581.1
 C4orf47

chromosome 4 open reading frame 47

chr3_-_9994021 0.246 ENST00000411976.2
ENST00000412055.1
 PRRT3

proline-rich transmembrane protein 3

chr9_+_1050331 0.211 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
 DMRT2


doublesex and mab-3 related transcription factor 2


chr1_+_211500129 0.210 ENST00000427925.2
ENST00000261464.5
 TRAF5

TNF receptor-associated factor 5

chr10_+_135192695 0.179 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
 PAOX


polyamine oxidase (exo-N4-amino)


chr4_+_170541835 0.170 ENST00000504131.2
 CLCN3
chloride channel, voltage-sensitive 3
chr4_+_170541678 0.169 ENST00000360642.3
ENST00000512813.1
 CLCN3

chloride channel, voltage-sensitive 3

chr11_-_46638720 0.141 ENST00000326737.3
 HARBI1
harbinger transposase derived 1
chr6_+_18155560 0.140 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
 KDM1B


lysine (K)-specific demethylase 1B


chr1_-_186344802 0.134 ENST00000451586.1
 TPR
translocated promoter region, nuclear basket protein
chr11_+_13690249 0.124 ENST00000532701.1
 FAR1
fatty acyl CoA reductase 1
chr1_-_55266865 0.110 ENST00000371274.4
 TTC22
tetratricopeptide repeat domain 22
chr9_+_96026230 0.109 ENST00000448251.1
 WNK2
WNK lysine deficient protein kinase 2
chr4_+_170541660 0.109 ENST00000513761.1
ENST00000347613.4
 CLCN3

chloride channel, voltage-sensitive 3

chr5_-_137911049 0.106 ENST00000297185.3
 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr16_+_29973351 0.106 ENST00000602948.1
ENST00000279396.6
ENST00000575829.2
ENST00000561899.2
 TMEM219



transmembrane protein 219



chr5_-_93447333 0.106 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
 FAM172A


family with sequence similarity 172, member A


chr1_-_55266926 0.105 ENST00000371276.4
 TTC22
tetratricopeptide repeat domain 22
chr5_+_10353780 0.100 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
 MARCH6


membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase


chr9_-_37576226 0.093 ENST00000432825.2
 FBXO10
F-box protein 10
chr22_-_37415475 0.086 ENST00000403892.3
ENST00000249042.3
ENST00000438203.1
 TST


thiosulfate sulfurtransferase (rhodanese)


chr19_-_55652290 0.081 ENST00000589745.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr1_+_186344945 0.080 ENST00000419367.3
ENST00000287859.6
 C1orf27

chromosome 1 open reading frame 27

chr1_+_186344883 0.078 ENST00000367470.3
 C1orf27
chromosome 1 open reading frame 27
chr7_+_117824086 0.066 ENST00000249299.2
ENST00000424702.1
 NAA38

N(alpha)-acetyltransferase 38, NatC auxiliary subunit

chr2_-_105946491 0.065 ENST00000393359.2
 TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr10_-_1034237 0.065 ENST00000381466.1
 AL359878.1
Uncharacterized protein
chr10_+_1034338 0.062 ENST00000360803.4
ENST00000538293.1
 GTPBP4

GTP binding protein 4

chr17_+_34136459 0.059 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
 TAF15





TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa





chr17_+_75181292 0.051 ENST00000431431.2
 SEC14L1
SEC14-like 1 (S. cerevisiae)
chr17_+_7517264 0.051 ENST00000572182.1
ENST00000574539.1
ENST00000576728.1
ENST00000575314.1
ENST00000570547.1
ENST00000572262.1
ENST00000576478.1
ENST00000593717.1
 SHBG






AC007421.1
sex hormone-binding globulin






AC007421.1
chr20_+_37377085 0.050 ENST00000243903.4
 ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr13_+_53226963 0.048 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
 SUGT1


SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)


chr2_-_240322643 0.042 ENST00000345617.3
 HDAC4
histone deacetylase 4
chr15_+_85523671 0.037 ENST00000310298.4
ENST00000557957.1
 PDE8A

phosphodiesterase 8A

chr1_+_25664408 0.036 ENST00000374358.4
 TMEM50A
transmembrane protein 50A
chr6_-_31763408 0.034 ENST00000444930.2
 VARS
valyl-tRNA synthetase
chr11_+_46638805 0.031 ENST00000434074.1
ENST00000312040.4
ENST00000451945.1
 ATG13


autophagy related 13


chrX_+_102631248 0.030 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
 NGFRAP1


nerve growth factor receptor (TNFRSF16) associated protein 1


chr1_+_214161272 0.028 ENST00000498508.2
ENST00000366958.4
 PROX1

prospero homeobox 1

chr19_+_52074502 0.024 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
 ZNF175


zinc finger protein 175


chr12_-_74686314 0.021 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
 RP11-81H3.2


RP11-81H3.2


chr13_+_21750780 0.020 ENST00000309594.4
 MRP63
mitochondrial ribosomal protein 63
chr16_+_68573116 0.020 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
 ZFP90




ZFP90 zinc finger protein




chr10_-_73611046 0.020 ENST00000394934.1
ENST00000394936.3
 PSAP

prosaposin

chr11_+_13690200 0.019 ENST00000354817.3
 FAR1
fatty acyl CoA reductase 1
chr19_+_35739897 0.017 ENST00000605618.1
ENST00000427250.1
ENST00000601623.1
 LSR


lipolysis stimulated lipoprotein receptor


chr1_-_246670519 0.016 ENST00000388985.4
ENST00000490107.1
 SMYD3

SET and MYND domain containing 3

chr2_+_198365122 0.014 ENST00000604458.1
 HSPE1-MOB4
HSPE1-MOB4 readthrough
chr19_+_37998031 0.014 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
 ZNF793


zinc finger protein 793


chr12_+_52463751 0.013 ENST00000336854.4
ENST00000550604.1
ENST00000553049.1
ENST00000548915.1
 C12orf44



chromosome 12 open reading frame 44



chr7_+_100303676 0.013 ENST00000303151.4
 POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr12_+_79258444 0.013 ENST00000261205.4
 SYT1
synaptotagmin I
chr1_+_6615241 0.012 ENST00000333172.6
ENST00000328191.4
ENST00000351136.3
 TAS1R1


taste receptor, type 1, member 1


chr2_+_87144738 0.012 ENST00000559485.1
 RGPD1
RANBP2-like and GRIP domain containing 1
chr1_-_228296956 0.010 ENST00000366744.1
ENST00000348259.5
ENST00000366747.3
ENST00000366746.3
ENST00000295008.4
ENST00000336520.3
ENST00000366731.5
ENST00000411464.2
ENST00000457264.1
ENST00000336300.5
ENST00000430433.1
ENST00000391867.3
 MRPL55











mitochondrial ribosomal protein L55











chr13_+_45563721 0.009 ENST00000361121.2
 GPALPP1
GPALPP motifs containing 1
chr19_+_35739782 0.009 ENST00000347609.4
 LSR
lipolysis stimulated lipoprotein receptor
chr6_-_116601044 0.008 ENST00000368608.3
 TSPYL1
TSPY-like 1
chrX_+_128913906 0.008 ENST00000356892.3
 SASH3
SAM and SH3 domain containing 3
chr22_+_30163340 0.008 ENST00000330029.6
ENST00000401406.3
 UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr5_+_89854595 0.007 ENST00000405460.2
 GPR98
G protein-coupled receptor 98
chr12_+_79258547 0.006 ENST00000457153.2
 SYT1
synaptotagmin I
chr17_+_48585745 0.006 ENST00000323776.5
 MYCBPAP
MYCBP associated protein
chr5_+_102455968 0.004 ENST00000358359.3
 PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr16_+_21964662 0.004 ENST00000561553.1
ENST00000565331.1
 UQCRC2

ubiquinol-cytochrome c reductase core protein II

chr2_+_172290707 0.004 ENST00000375255.3
ENST00000539783.1
 DCAF17

DDB1 and CUL4 associated factor 17

chr11_-_61560254 0.003 ENST00000543510.1
 TMEM258
transmembrane protein 258
chr6_+_53659746 0.002 ENST00000370888.1
 LRRC1
leucine rich repeat containing 1
chr8_-_109260897 0.002 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
 EIF3E





eukaryotic translation initiation factor 3, subunit E





chr3_+_49236910 0.000 ENST00000452691.2
ENST00000366429.2
 CCDC36

coiled-coil domain containing 36


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.2 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.1 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.7 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.1 GO:0033341 regulation of collagen binding(GO:0033341)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation