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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for AHR_ARNT2
Z-value: 1.15
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Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT2 | hg38_v1_chr15_+_80404320_80404414, hg38_v1_chr15_+_80441229_80441313 | -0.69 | 2.8e-05 | Click! |
| AHR | hg38_v1_chr7_+_17298642_17298658 | 0.64 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 10.1 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 1.8 | 5.5 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.3 | 5.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 4.9 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 0.5 | 4.9 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 4.9 | GO:0048515 | spermatid differentiation(GO:0048515) |
| 1.0 | 4.8 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 4.7 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.0 | 4.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.5 | 5.4 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.8 | 4.8 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.7 | 4.6 | GO:0098536 | deuterosome(GO:0098536) |
| 0.8 | 4.1 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.0 | 4.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 4.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 3.7 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.2 | 3.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 3.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 6.9 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 5.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.4 | 5.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.3 | 4.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 4.4 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 4.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 4.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 3.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 3.5 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 6.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 4.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 3.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 3.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 5.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 5.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 4.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 4.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 4.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 3.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 3.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 3.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 2.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |