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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ATF2_ATF1_ATF3
Z-value: 1.57
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Transcription factors associated with ATF2_ATF1_ATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF3 | hg38_v1_chr1_+_212565334_212565414 | -0.66 | 7.1e-05 | Click! |
| ATF1 | hg38_v1_chr12_+_50764509_50764613 | 0.33 | 7.6e-02 | Click! |
| ATF2 | hg38_v1_chr2_-_175168159_175168213 | 0.22 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_67619911 Show fit | 9.50 |
ENST00000261783.4
|
arginase 2 |
|
| chr8_-_10839818 Show fit | 8.62 |
ENST00000554914.1
|
PIN2 (TERF1) interacting telomerase inhibitor 1 |
|
| chr4_+_74445302 Show fit | 8.01 |
ENST00000502307.1
|
amphiregulin |
|
| chr4_+_74445126 Show fit | 7.65 |
ENST00000395748.8
|
amphiregulin |
|
| chr19_-_51002527 Show fit | 7.41 |
ENST00000595238.1
ENST00000600767.5 |
kallikrein related peptidase 8 |
|
| chr2_-_215436061 Show fit | 7.12 |
ENST00000421182.5
ENST00000432072.6 ENST00000323926.10 ENST00000336916.8 ENST00000357867.8 ENST00000359671.5 ENST00000446046.5 ENST00000354785.11 ENST00000356005.8 ENST00000443816.5 ENST00000426059.1 |
fibronectin 1 |
|
| chr6_+_126340107 Show fit | 6.75 |
ENST00000368328.5
ENST00000368326.5 ENST00000368325.5 |
centromere protein W |
|
| chr19_-_50511146 Show fit | 6.68 |
ENST00000594350.1
ENST00000601423.5 |
Josephin domain containing 2 |
|
| chr4_-_121823843 Show fit | 6.66 |
ENST00000274026.10
|
cyclin A2 |
|
| chr7_+_5592805 Show fit | 6.30 |
ENST00000382361.8
|
fascin actin-bundling protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 18.2 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.5 | 16.1 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 1.7 | 15.7 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) |
| 0.7 | 10.2 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 2.5 | 10.1 | GO:1904744 | positive regulation of telomeric DNA binding(GO:1904744) |
| 1.6 | 9.5 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.6 | 9.5 | GO:0000050 | urea cycle(GO:0000050) |
| 0.5 | 7.2 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 2.4 | 7.1 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 2.3 | 6.9 | GO:0071314 | cellular response to cocaine(GO:0071314) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 21.1 | GO:0009986 | cell surface(GO:0009986) |
| 1.1 | 19.0 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.0 | 18.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 15.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 8.1 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 7.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.6 | 7.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.7 | 6.7 | GO:0001940 | female pronucleus(GO:0001939) male pronucleus(GO:0001940) |
| 0.0 | 6.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 17.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 2.3 | 16.4 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.3 | 14.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 13.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 12.5 | GO:0060090 | binding, bridging(GO:0060090) |
| 0.8 | 12.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 1.9 | 11.2 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.1 | 10.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.9 | 9.5 | GO:0043515 | kinetochore binding(GO:0043515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 17.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 14.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 12.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 9.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 8.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.3 | 8.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.4 | 8.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 6.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.7 | 18.9 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.9 | 18.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.2 | 17.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 15.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 7.8 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 0.2 | 7.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.3 | 6.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 5.8 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 5.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |