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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ATF4

Z-value: 0.94

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.17 ATF4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg38_v1_chr22_+_39520553_395206040.496.1e-03Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_24949026 4.43 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr21_-_43075831 3.51 ENST00000398158.5
ENST00000398165.8
CBS
cystathionine beta-synthase
chr21_-_6467509 3.31 ENST00000624406.3
ENST00000398168.5
ENST00000624934.3
CBSL
cystathionine beta-synthase like
chr15_+_40953463 2.83 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr2_-_215436061 2.82 ENST00000421182.5
ENST00000432072.6
ENST00000323926.10
ENST00000336916.8
ENST00000357867.8
ENST00000359671.5
ENST00000446046.5
ENST00000354785.11
ENST00000356005.8
ENST00000443816.5
ENST00000426059.1
FN1
fibronectin 1
chr10_+_100347225 2.49 ENST00000370355.3
SCD
stearoyl-CoA desaturase
chr12_+_57229694 2.01 ENST00000557487.5
ENST00000328923.8
ENST00000555634.5
ENST00000556689.5
SHMT2
serine hydroxymethyltransferase 2
chr19_-_50511146 1.80 ENST00000594350.1
ENST00000601423.5
JOSD2
Josephin domain containing 2
chr12_+_57230301 1.69 ENST00000553474.5
SHMT2
serine hydroxymethyltransferase 2
chr19_-_50511173 1.58 ENST00000598418.6
JOSD2
Josephin domain containing 2
chr14_-_100375333 1.58 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
WARS1
tryptophanyl-tRNA synthetase 1
chr14_+_24094301 1.55 ENST00000545054.6
ENST00000561286.5
ENST00000216780.9
ENST00000558096.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr19_-_50511203 1.54 ENST00000595669.5
JOSD2
Josephin domain containing 2
chr9_+_78297143 1.48 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr12_+_57230086 1.47 ENST00000414700.7
ENST00000557703.5
SHMT2
serine hydroxymethyltransferase 2
chr12_+_57230336 1.45 ENST00000555773.5
ENST00000554975.5
ENST00000449049.7
SHMT2
serine hydroxymethyltransferase 2
chr3_-_48088800 1.42 ENST00000423088.5
MAP4
microtubule associated protein 4
chr11_+_62881686 1.42 ENST00000536981.6
ENST00000539891.6
SLC3A2
solute carrier family 3 member 2
chr6_+_150865815 1.40 ENST00000367308.8
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr7_+_30594823 1.40 ENST00000675810.1
ENST00000674815.1
ENST00000454308.6
ENST00000389266.8
ENST00000675693.1
ENST00000675651.1
ENST00000674851.1
GARS1
glycyl-tRNA synthetase 1
chr16_+_46884323 1.36 ENST00000340124.9
GPT2
glutamic--pyruvic transaminase 2
chr3_-_48089203 1.36 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr14_-_100375602 1.32 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
WARS1
tryptophanyl-tRNA synthetase 1
chr9_+_78297117 1.22 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr3_-_33645253 1.20 ENST00000333778.10
CLASP2
cytoplasmic linker associated protein 2
chr3_-_33645433 1.16 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr22_+_50481515 1.15 ENST00000395737.2
ENST00000395738.2
ADM2
adrenomedullin 2
chr14_+_24094053 1.11 ENST00000559250.5
ENST00000560736.5
ENST00000396973.8
ENST00000559837.5
PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
chr12_-_57520480 1.10 ENST00000642841.1
ENST00000547303.5
ENST00000552740.5
ENST00000547526.1
ENST00000346473.8
ENST00000551116.5
ENSG00000285133.1
DDIT3
novel protein
DNA damage inducible transcript 3
chr3_+_101849505 1.04 ENST00000326151.9
ENST00000326172.9
NFKBIZ
NFKB inhibitor zeta
chr5_+_33440696 1.03 ENST00000502553.5
ENST00000514259.5
TARS1
threonyl-tRNA synthetase 1
chr12_+_93569814 0.99 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr17_-_81937320 0.98 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937277 0.98 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937221 0.96 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr5_+_33440947 0.87 ENST00000455217.6
ENST00000265112.8
TARS1
threonyl-tRNA synthetase 1
chr3_-_48088824 0.87 ENST00000439356.2
ENST00000395734.7
ENST00000426837.6
MAP4
microtubule associated protein 4
chr1_+_32817442 0.84 ENST00000373476.5
ENST00000529027.5
S100PBP
S100P binding protein
chr15_+_40594001 0.84 ENST00000346991.9
ENST00000528975.5
KNL1
kinetochore scaffold 1
chr2_-_55334529 0.77 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr11_-_3057386 0.75 ENST00000529772.5
ENST00000278224.13
ENST00000380525.9
CARS1
cysteinyl-tRNA synthetase 1
chr15_+_40594241 0.74 ENST00000532056.5
ENST00000527044.5
ENST00000399668.7
KNL1
kinetochore scaffold 1
chr8_-_126557691 0.72 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr12_-_116881062 0.72 ENST00000550505.5
HRK
harakiri, BCL2 interacting protein
chr7_-_56034133 0.71 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr1_+_32817645 0.68 ENST00000526230.1
ENST00000373475.10
ENST00000531256.1
ENST00000482212.1
S100PBP
S100P binding protein
chr21_-_30492008 0.66 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr12_-_46268989 0.65 ENST00000549049.5
ENST00000439706.5
ENST00000398637.10
SLC38A1
solute carrier family 38 member 1
chr19_+_48755512 0.58 ENST00000593756.6
FGF21
fibroblast growth factor 21
chr2_-_240820945 0.57 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
KIF1A
kinesin family member 1A
chr1_-_44031352 0.57 ENST00000372306.7
ENST00000475075.6
SLC6A9
solute carrier family 6 member 9
chr19_+_33374312 0.54 ENST00000585933.2
CEBPG
CCAAT enhancer binding protein gamma
chr19_-_46784905 0.54 ENST00000594991.5
SLC1A5
solute carrier family 1 member 5
chr9_+_36169382 0.53 ENST00000335119.4
CCIN
calicin
chr17_-_42676980 0.53 ENST00000587627.1
ENST00000591022.6
ENST00000293349.10
PLEKHH3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr1_-_32817311 0.52 ENST00000373477.9
ENST00000675785.1
YARS1
tyrosyl-tRNA synthetase 1
chr1_-_44031446 0.52 ENST00000372310.8
ENST00000466926.1
SLC6A9
solute carrier family 6 member 9
chr9_-_92293674 0.49 ENST00000683679.1
ENST00000683565.1
ENST00000684557.1
ENST00000682578.1
ENST00000443024.7
ENST00000375643.7
ENST00000683469.1
IARS1
isoleucyl-tRNA synthetase 1
chr19_-_46784733 0.49 ENST00000593713.1
ENST00000598022.1
ENST00000434726.6
SLC1A5
solute carrier family 1 member 5
chr19_-_8698789 0.47 ENST00000324436.5
ACTL9
actin like 9
chr5_+_44808930 0.45 ENST00000507110.6
MRPS30
mitochondrial ribosomal protein S30
chr22_+_41833079 0.45 ENST00000612482.4
ENST00000361204.9
SREBF2
sterol regulatory element binding transcription factor 2
chr3_+_11272413 0.45 ENST00000446450.6
ENST00000354956.9
ENST00000354449.7
ENST00000419112.5
ATG7
autophagy related 7
chr12_-_10172117 0.41 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
OLR1
oxidized low density lipoprotein receptor 1
chr19_+_48756067 0.41 ENST00000222157.5
FGF21
fibroblast growth factor 21
chr1_-_204411804 0.40 ENST00000367188.5
PPP1R15B
protein phosphatase 1 regulatory subunit 15B
chr19_-_8698705 0.40 ENST00000612068.1
ACTL9
actin like 9
chr17_-_79839387 0.40 ENST00000448310.1
ENST00000269397.9
CBX4
chromobox 4
chr17_+_75093287 0.40 ENST00000538213.6
ENST00000584118.1
SLC16A5
solute carrier family 16 member 5
chr16_-_67660224 0.38 ENST00000602320.1
ENST00000620761.6
ACD
ACD shelterin complex subunit and telomerase recruitment factor
chrX_+_24054931 0.34 ENST00000253039.9
ENST00000423068.1
EIF2S3
eukaryotic translation initiation factor 2 subunit gamma
chr6_+_159890964 0.34 ENST00000434562.2
ENST00000674077.2
ENSG00000236823.2
MAS1
novel transcript
MAS1 proto-oncogene, G protein-coupled receptor
chr2_-_240820205 0.31 ENST00000647731.1
ENST00000648680.1
ENST00000649306.1
ENST00000648129.1
ENST00000498729.9
ENST00000320389.12
ENST00000648364.1
ENST00000647885.1
ENST00000404283.9
ENST00000649096.1
KIF1A
kinesin family member 1A
chr7_-_48029102 0.30 ENST00000297325.9
ENST00000412142.5
ENST00000395572.6
SUN3
Sad1 and UNC84 domain containing 3
chr12_-_116881431 0.29 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein
chr1_+_239719542 0.29 ENST00000448020.1
CHRM3
cholinergic receptor muscarinic 3
chr1_-_178871060 0.29 ENST00000234816.7
ANGPTL1
angiopoietin like 1
chr11_-_57324907 0.28 ENST00000358252.8
TNKS1BP1
tankyrase 1 binding protein 1
chr7_+_99408958 0.27 ENST00000222969.10
BUD31
BUD31 homolog
chr16_-_67660694 0.25 ENST00000219251.13
ENST00000620338.4
ACD
ACD shelterin complex subunit and telomerase recruitment factor
chr19_+_33373694 0.24 ENST00000284000.9
CEBPG
CCAAT enhancer binding protein gamma
chr1_-_178871022 0.22 ENST00000367629.1
ANGPTL1
angiopoietin like 1
chr7_-_116030735 0.22 ENST00000393485.5
TFEC
transcription factor EC
chr1_+_162632454 0.21 ENST00000367921.8
ENST00000367922.7
DDR2
discoidin domain receptor tyrosine kinase 2
chr1_+_233904656 0.20 ENST00000366618.8
SLC35F3
solute carrier family 35 member F3
chr1_-_220046432 0.19 ENST00000609181.5
ENST00000366923.8
EPRS1
glutamyl-prolyl-tRNA synthetase 1
chr19_+_1450113 0.19 ENST00000590469.6
ENST00000590877.5
ENST00000233607.6
APC2
APC regulator of WNT signaling pathway 2
chr17_-_48626325 0.19 ENST00000311177.7
HOXB9
homeobox B9
chr7_-_116030750 0.18 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr22_-_29061831 0.18 ENST00000216071.5
C22orf31
chromosome 22 open reading frame 31
chr7_-_18027839 0.18 ENST00000506618.5
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1 like 1
chr1_+_52056255 0.17 ENST00000489308.6
BTF3L4
basic transcription factor 3 like 4
chr4_+_94207596 0.16 ENST00000359052.8
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr17_+_41689862 0.12 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr10_+_49299159 0.12 ENST00000374144.8
C10orf71
chromosome 10 open reading frame 71
chr16_-_70289480 0.11 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr4_-_152536045 0.08 ENST00000603548.6
ENST00000281708.10
FBXW7
F-box and WD repeat domain containing 7
chr1_-_19923617 0.08 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr3_+_148697784 0.06 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chrX_-_134658450 0.05 ENST00000359237.9
PLAC1
placenta enriched 1
chr9_+_97983332 0.05 ENST00000339399.5
ANP32B
acidic nuclear phosphoprotein 32 family member B
chr10_+_131900999 0.05 ENST00000455566.6
PPP2R2D
protein phosphatase 2 regulatory subunit Bdelta
chr7_-_99408548 0.05 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr1_+_154272589 0.05 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr12_+_56468561 0.04 ENST00000338146.7
SPRYD4
SPRY domain containing 4
chr5_+_154755272 0.03 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr14_-_24576240 0.03 ENST00000216336.3
CTSG
cathepsin G
chr4_+_94207845 0.03 ENST00000457823.6
ENST00000354268.9
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_144205250 0.02 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr11_+_119085200 0.02 ENST00000650101.1
HMBS
hydroxymethylbilane synthase
chr5_+_179678613 0.01 ENST00000681674.1
ENST00000681712.1
ENST00000681903.1
CANX
calnexin
chr12_+_57455266 0.01 ENST00000266646.3
INHBE
inhibin subunit beta E
chr6_+_72366730 0.01 ENST00000414192.2
RIMS1
regulating synaptic membrane exocytosis 1
chr11_+_119084873 0.00 ENST00000652429.1
ENST00000442944.7
ENST00000537841.5
ENST00000542729.5
ENST00000546302.6
ENST00000536813.6
ENST00000544387.5
ENST00000543090.5
HMBS
hydroxymethylbilane synthase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
1.1 6.6 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.9 2.8 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.9 2.7 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.9 4.4 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.6 3.6 GO:0051012 microtubule sliding(GO:0051012)
0.4 1.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.3 2.6 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.3 1.4 GO:0042853 L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.3 2.7 GO:0006116 NADH oxidation(GO:0006116)
0.3 1.0 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 1.0 GO:1904640 response to methionine(GO:1904640)
0.2 1.4 GO:0060356 leucine import(GO:0060356)
0.2 2.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.2 1.0 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 0.6 GO:1904744 positive regulation of telomeric DNA binding(GO:1904744)
0.1 2.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.8 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.4 GO:1901859 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) response to fluoride(GO:1902617)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.4 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 1.0 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 2.5 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 1.0 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0015888 thiamine transport(GO:0015888)
0.0 0.1 GO:0010868 negative regulation of triglyceride biosynthetic process(GO:0010868) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.9 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 1.1 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.6 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.1 GO:0007549 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:1901355 response to rapamycin(GO:1901355)
0.0 4.4 GO:0016579 protein deubiquitination(GO:0016579)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.6 GO:0070552 BRISC complex(GO:0070552)
0.2 2.8 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 0.5 GO:0033150 cytoskeletal calyx(GO:0033150)
0.1 1.1 GO:0035976 AP1 complex(GO:0035976)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.6 GO:0070187 telosome(GO:0070187)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 4.1 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.0 8.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 1.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.8 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
1.1 6.6 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.9 4.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.9 2.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.7 2.8 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.6 2.5 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.5 1.4 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.4 2.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 1.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.3 1.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 0.5 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.1 0.7 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.0 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.7 GO:0008483 transaminase activity(GO:0008483)
0.1 2.4 GO:0051010 dystroglycan binding(GO:0002162) microtubule plus-end binding(GO:0051010)
0.1 1.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.4 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 2.8 GO:0016504 peptidase activator activity(GO:0016504)
0.0 4.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.8 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.6 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.4 GO:0032183 SUMO binding(GO:0032183)
0.0 1.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 4.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 4.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 3.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.7 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine