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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for BARHL1
Z-value: 2.26
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Transcription factors associated with BARHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL1 | hg38_v1_chr9_+_132582581_132582617 | -0.53 | 2.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_19946970 Show fit | 19.32 |
ENST00000344838.8
|
EF-hand domain family member B |
|
| chr12_-_71157992 Show fit | 18.51 |
ENST00000247829.8
|
tetraspanin 8 |
|
| chr12_-_71157872 Show fit | 16.85 |
ENST00000546561.2
|
tetraspanin 8 |
|
| chr2_+_227871618 Show fit | 13.36 |
ENST00000309931.3
ENST00000440997.1 |
dynein assembly factor with WD repeats 1 |
|
| chr6_+_151494007 Show fit | 13.30 |
ENST00000239374.8
|
coiled-coil domain containing 170 |
|
| chr1_+_103750406 Show fit | 12.59 |
ENST00000370079.3
|
amylase alpha 1C |
|
| chr3_-_180679468 Show fit | 11.86 |
ENST00000651046.1
ENST00000476379.6 |
coiled-coil domain containing 39 |
|
| chr3_-_197959977 Show fit | 11.70 |
ENST00000265239.11
|
IQ motif containing G |
|
| chr20_+_33283205 Show fit | 11.25 |
ENST00000253354.2
|
BPI fold containing family B member 1 |
|
| chr5_+_122129533 Show fit | 11.15 |
ENST00000296600.5
ENST00000504912.1 ENST00000505843.1 |
zinc finger protein 474 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 22.7 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 4.1 | 20.3 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 1.1 | 19.4 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.9 | 18.7 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.3 | 18.6 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.1 | 18.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.9 | 16.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.1 | 15.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.2 | 15.4 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 1.2 | 13.5 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 55.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.4 | 45.2 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 1.1 | 21.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 14.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 2.0 | 14.0 | GO:0002177 | manchette(GO:0002177) |
| 1.6 | 12.8 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 11.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 10.9 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.7 | 9.8 | GO:0097433 | dense body(GO:0097433) |
| 0.3 | 9.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 33.8 | GO:0005178 | integrin binding(GO:0005178) |
| 1.3 | 25.9 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 2.6 | 21.0 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.9 | 15.6 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.5 | 14.7 | GO:0031005 | filamin binding(GO:0031005) |
| 4.4 | 13.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.0 | 13.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.8 | 11.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.4 | 11.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 11.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 6.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 6.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 5.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 4.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 3.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 3.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 31.1 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 1.9 | 24.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.6 | 20.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 18.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 15.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.6 | 12.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.6 | 8.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.3 | 8.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 7.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |