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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BBX

Z-value: 0.35

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.19 BBX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg38_v1_chr3_+_107522936_1075230030.319.9e-02Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_16881967 2.08 ENST00000402239.7
ENST00000310398.7
ENST00000414935.1
AGR3
anterior gradient 3, protein disulphide isomerase family member
chr11_+_60699605 1.79 ENST00000300226.7
MS4A8
membrane spanning 4-domains A8
chr1_-_161367872 1.36 ENST00000367974.2
CFAP126
cilia and flagella associated protein 126
chr4_-_122621011 1.08 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr6_+_52420107 0.99 ENST00000636489.1
ENST00000637089.1
ENST00000637353.1
ENST00000637263.1
EFHC1
EF-hand domain containing 1
chr20_-_7940444 0.96 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr1_+_36084079 0.73 ENST00000207457.8
TEKT2
tektin 2
chr11_-_22625804 0.42 ENST00000327470.6
FANCF
FA complementation group F
chr1_-_216805367 0.42 ENST00000360012.7
ESRRG
estrogen related receptor gamma
chr2_-_61854119 0.41 ENST00000405894.3
FAM161A
FAM161 centrosomal protein A
chr2_-_61854013 0.40 ENST00000404929.6
FAM161A
FAM161 centrosomal protein A
chr8_-_28490220 0.38 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
FBXO16
F-box protein 16
chr8_-_144605699 0.37 ENST00000377307.6
ENST00000276826.5
ARHGAP39
Rho GTPase activating protein 39
chr2_-_119366682 0.36 ENST00000409877.5
ENST00000409523.1
ENST00000409466.6
C2orf76
chromosome 2 open reading frame 76
chr6_-_135497230 0.34 ENST00000681365.1
AHI1
Abelson helper integration site 1
chr13_+_76948500 0.32 ENST00000377462.6
ACOD1
aconitate decarboxylase 1
chr12_-_100262356 0.31 ENST00000548313.5
DEPDC4
DEP domain containing 4
chr6_+_31927486 0.30 ENST00000442278.6
C2
complement C2
chr1_+_78620722 0.27 ENST00000679848.1
IFI44L
interferon induced protein 44 like
chr6_-_25874212 0.26 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr17_+_21126947 0.25 ENST00000579303.5
DHRS7B
dehydrogenase/reductase 7B
chr12_-_39340963 0.25 ENST00000552961.5
KIF21A
kinesin family member 21A
chr17_+_42798881 0.22 ENST00000588527.5
CNTD1
cyclin N-terminal domain containing 1
chr17_+_42798857 0.22 ENST00000588408.6
CNTD1
cyclin N-terminal domain containing 1
chr3_-_112499457 0.21 ENST00000334529.10
BTLA
B and T lymphocyte associated
chr3_-_112499358 0.21 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr1_+_158461574 0.21 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
OR10K1
olfactory receptor family 10 subfamily K member 1
chr11_+_58622659 0.20 ENST00000361987.6
CNTF
ciliary neurotrophic factor
chr4_-_103099811 0.19 ENST00000504285.5
ENST00000296424.9
BDH2
3-hydroxybutyrate dehydrogenase 2
chr9_-_13175824 0.18 ENST00000545857.5
MPDZ
multiple PDZ domain crumbs cell polarity complex component
chr16_-_28363508 0.17 ENST00000532254.1
NPIPB6
nuclear pore complex interacting protein family member B6
chr12_+_55362975 0.17 ENST00000641576.1
OR6C75
olfactory receptor family 6 subfamily C member 75
chr4_+_107824555 0.16 ENST00000394684.8
SGMS2
sphingomyelin synthase 2
chr16_+_56191476 0.15 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr1_-_37514743 0.15 ENST00000448519.2
ENST00000373075.6
ENST00000373073.8
ENST00000296214.10
MEAF6
MYST/Esa1 associated factor 6
chr10_-_92243246 0.15 ENST00000412050.8
ENST00000614585.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr3_-_146528750 0.15 ENST00000483300.5
PLSCR1
phospholipid scramblase 1
chr14_+_63761836 0.15 ENST00000674003.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr5_+_126423122 0.15 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr6_+_117482634 0.15 ENST00000296955.12
ENST00000338728.10
DCBLD1
discoidin, CUB and LCCL domain containing 1
chr21_+_30396030 0.15 ENST00000355459.4
KRTAP13-1
keratin associated protein 13-1
chr14_+_67189393 0.14 ENST00000524532.5
ENST00000612183.4
ENST00000530728.5
FAM71D
family with sequence similarity 71 member D
chr17_+_68259164 0.14 ENST00000448504.6
ARSG
arylsulfatase G
chr1_-_153150884 0.13 ENST00000368748.5
SPRR2G
small proline rich protein 2G
chr5_+_162067500 0.13 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr4_-_158723355 0.13 ENST00000307720.4
PPID
peptidylprolyl isomerase D
chr6_-_49744434 0.13 ENST00000433368.6
ENST00000354620.4
CRISP3
cysteine rich secretory protein 3
chr16_+_28751787 0.12 ENST00000357796.7
ENST00000550983.1
NPIPB9
nuclear pore complex interacting protein family member B9
chr20_-_31722854 0.12 ENST00000307677.5
BCL2L1
BCL2 like 1
chr19_+_6887560 0.12 ENST00000250572.12
ENST00000381407.9
ENST00000450315.7
ENST00000312053.9
ENST00000381404.8
ADGRE1
adhesion G protein-coupled receptor E1
chr6_-_49744378 0.11 ENST00000371159.8
ENST00000263045.9
CRISP3
cysteine rich secretory protein 3
chr7_-_16833411 0.11 ENST00000412973.1
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr5_+_141135199 0.11 ENST00000231134.8
ENST00000623915.1
PCDHB5
protocadherin beta 5
chr10_+_110005804 0.11 ENST00000360162.7
ADD3
adducin 3
chr20_-_31722949 0.10 ENST00000376055.9
BCL2L1
BCL2 like 1
chr6_-_29375291 0.10 ENST00000396806.3
OR12D3
olfactory receptor family 12 subfamily D member 3
chr9_+_35161951 0.10 ENST00000617908.4
ENST00000619578.4
UNC13B
unc-13 homolog B
chr21_+_18244828 0.10 ENST00000299295.7
CHODL
chondrolectin
chr9_-_5833014 0.09 ENST00000339450.10
ERMP1
endoplasmic reticulum metallopeptidase 1
chr4_-_185775890 0.09 ENST00000437304.6
SORBS2
sorbin and SH3 domain containing 2
chr3_-_58666765 0.09 ENST00000358781.7
FAM3D
FAM3 metabolism regulating signaling molecule D
chr19_+_17719471 0.09 ENST00000600186.5
ENST00000597735.5
ENST00000324096.9
MAP1S
microtubule associated protein 1S
chr4_-_112636858 0.08 ENST00000503172.5
ENST00000505019.6
ENST00000309071.9
ZGRF1
zinc finger GRF-type containing 1
chr19_-_18397596 0.08 ENST00000595840.1
ENST00000339007.4
LRRC25
leucine rich repeat containing 25
chrX_-_19799751 0.07 ENST00000379698.8
SH3KBP1
SH3 domain containing kinase binding protein 1
chr7_+_117480011 0.07 ENST00000649406.1
ENST00000648260.1
ENST00000003084.11
CFTR
CF transmembrane conductance regulator
chr20_-_31722533 0.07 ENST00000677194.1
ENST00000434194.2
ENST00000376062.6
BCL2L1
BCL2 like 1
chr18_-_23437927 0.07 ENST00000578520.5
ENST00000383233.8
TMEM241
transmembrane protein 241
chr9_+_35162000 0.07 ENST00000396787.5
ENST00000378495.7
ENST00000635942.1
ENST00000378496.8
UNC13B
unc-13 homolog B
chr15_-_75455767 0.07 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr17_-_75785486 0.07 ENST00000586607.5
H3-3B
H3.3 histone B
chr4_+_158315309 0.07 ENST00000460056.6
RXFP1
relaxin family peptide receptor 1
chr5_+_162067458 0.07 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr5_-_62403506 0.06 ENST00000680062.1
DIMT1
DIMT1 rRNA methyltransferase and ribosome maturation factor
chr14_+_74763308 0.06 ENST00000325680.12
ENST00000552421.5
YLPM1
YLP motif containing 1
chr8_-_107498041 0.06 ENST00000297450.7
ANGPT1
angiopoietin 1
chr4_-_185775271 0.06 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr15_+_72118392 0.06 ENST00000340912.6
SENP8
SUMO peptidase family member, NEDD8 specific
chr5_+_150661243 0.06 ENST00000517768.6
MYOZ3
myozenin 3
chr15_-_78299570 0.05 ENST00000560569.5
ENST00000558459.5
ENST00000558311.5
ENST00000267973.7
WDR61
WD repeat domain 61
chr8_-_107497909 0.05 ENST00000517746.6
ANGPT1
angiopoietin 1
chr9_-_2844058 0.05 ENST00000397885.3
PUM3
pumilio RNA binding family member 3
chr3_+_148865288 0.05 ENST00000296046.4
CPA3
carboxypeptidase A3
chr9_-_92404559 0.05 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr9_+_101185029 0.05 ENST00000395056.2
PLPPR1
phospholipid phosphatase related 1
chr14_+_22304051 0.05 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chr3_+_122680802 0.05 ENST00000474629.7
PARP14
poly(ADP-ribose) polymerase family member 14
chr14_+_20110739 0.05 ENST00000641386.2
ENST00000641633.2
OR4K17
olfactory receptor family 4 subfamily K member 17
chr3_+_51817596 0.05 ENST00000456080.5
ENSG00000285749.2
novel protein
chr12_-_16600703 0.04 ENST00000616247.4
LMO3
LIM domain only 3
chr3_-_169147734 0.04 ENST00000464456.5
MECOM
MDS1 and EVI1 complex locus
chr6_+_54308429 0.04 ENST00000259782.9
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr5_+_141430565 0.04 ENST00000613314.1
PCDHGA12
protocadherin gamma subfamily A, 12
chr5_-_59216826 0.04 ENST00000638939.1
PDE4D
phosphodiesterase 4D
chr15_+_40351026 0.04 ENST00000448599.2
PHGR1
proline, histidine and glycine rich 1
chr2_+_33436304 0.03 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr2_-_157325808 0.03 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ERMN
ermin
chr4_+_70592253 0.03 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr5_+_141182369 0.03 ENST00000609684.3
ENST00000625044.1
ENST00000623407.1
ENST00000623884.1
PCDHB16
ENSG00000279068.1
protocadherin beta 16
novel transcript
chr1_+_51617079 0.03 ENST00000447887.5
ENST00000428468.6
ENST00000453295.5
OSBPL9
oxysterol binding protein like 9
chr2_+_112181788 0.02 ENST00000272559.4
FBLN7
fibulin 7
chr17_+_29941605 0.02 ENST00000394835.7
EFCAB5
EF-hand calcium binding domain 5
chr3_+_111542178 0.02 ENST00000283285.10
ENST00000352690.9
CD96
CD96 molecule
chr2_-_230219902 0.02 ENST00000409815.6
SP110
SP110 nuclear body protein
chr5_+_150660841 0.02 ENST00000297130.4
MYOZ3
myozenin 3
chr5_-_22853320 0.02 ENST00000504376.6
ENST00000382254.6
CDH12
cadherin 12
chr4_-_993376 0.02 ENST00000398520.6
ENST00000398516.3
SLC26A1
solute carrier family 26 member 1
chr10_+_24208774 0.02 ENST00000376456.8
ENST00000458595.5
ENST00000376452.7
ENST00000430453.6
KIAA1217
KIAA1217
chr1_-_13285154 0.01 ENST00000357367.6
ENST00000614831.1
PRAMEF8
PRAME family member 8
chrX_-_126166273 0.01 ENST00000360028.4
DCAF12L2
DDB1 and CUL4 associated factor 12 like 2
chr14_+_21868822 0.01 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr6_-_130222813 0.01 ENST00000437477.6
ENST00000439090.7
SAMD3
sterile alpha motif domain containing 3
chr22_+_29438583 0.00 ENST00000354373.2
RFPL1
ret finger protein like 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.3 GO:0039008 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.1 1.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.3 GO:0072573 propionate metabolic process(GO:0019541) cellular response to progesterone stimulus(GO:0071393) tolerance induction to lipopolysaccharide(GO:0072573)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 0.2 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.2 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.1 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.0 0.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.3 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.3 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.2 1.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 2.0 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.0 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.0 0.1 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement