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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for BHLHE22_BHLHA15_BHLHE23
Z-value: 0.53
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Transcription factors associated with BHLHE22_BHLHA15_BHLHE23
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
BHLHE22
|
ENSG00000180828.3 | BHLHE22 |
|
BHLHA15
|
ENSG00000180535.4 | BHLHA15 |
|
BHLHE23
|
ENSG00000125533.6 | BHLHE23 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHE23 | hg38_v1_chr20_-_63006961_63007035 | 0.25 | 1.8e-01 | Click! |
| BHLHA15 | hg38_v1_chr7_+_98211431_98211474 | -0.13 | 4.9e-01 | Click! |
| BHLHE22 | hg38_v1_chr8_+_64580357_64580374 | -0.05 | 7.8e-01 | Click! |
Activity profile of BHLHE22_BHLHA15_BHLHE23 motif
Sorted Z-values of BHLHE22_BHLHA15_BHLHE23 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE22_BHLHA15_BHLHE23
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.2 | 2.6 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 0.9 | GO:2000670 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) positive regulation of dendritic cell apoptotic process(GO:2000670) |
| 0.1 | 0.4 | GO:0031445 | regulation of heterochromatin assembly(GO:0031445) positive regulation of heterochromatin assembly(GO:0031453) |
| 0.1 | 0.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.5 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.1 | 1.5 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 0.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 0.6 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.1 | 0.2 | GO:0001812 | positive regulation of type I hypersensitivity(GO:0001812) |
| 0.1 | 0.2 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.1 | 0.4 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.0 | 0.5 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.0 | 2.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.6 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 1.0 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 0.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.0 | 0.6 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 1.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.1 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.0 | 0.3 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 3.7 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 1.0 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.0 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.0 | 0.1 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.0 | 0.1 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.0 | 0.0 | GO:1901143 | insulin catabolic process(GO:1901143) |
| 0.0 | 0.2 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.0 | 0.3 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:0097636 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.2 | 3.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 0.2 | GO:0043159 | acrosomal matrix(GO:0043159) |
| 0.0 | 0.1 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.0 | 0.1 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.0 | 0.3 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.4 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.1 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.6 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.1 | 0.4 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.1 | 1.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.4 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.5 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 0.6 | GO:0102344 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.1 | 3.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 0.8 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.2 | GO:0097363 | protein O-GlcNAc transferase activity(GO:0097363) |
| 0.1 | 1.0 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.3 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.1 | 1.1 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.2 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.2 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863) |
| 0.0 | 0.2 | GO:0034603 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.0 | 0.6 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 2.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.1 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.0 | 0.0 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.0 | 0.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.0 | GO:0031626 | beta-endorphin binding(GO:0031626) |
| 0.0 | 0.1 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 2.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 1.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.2 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |