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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for BRCA1

Z-value: 0.21

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.23 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43125300_43125331-0.144.6e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_5970632 0.30 ENST00000455618.2
ENST00000405415.5
ENST00000404406.5
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B
chr20_+_33161768 0.28 ENST00000253362.6
BPIFA2
BPI fold containing family A member 2
chr2_+_98087160 0.27 ENST00000477737.6
VWA3B
von Willebrand factor A domain containing 3B
chr11_+_101914997 0.24 ENST00000263468.13
CEP126
centrosomal protein 126
chr17_-_43942472 0.23 ENST00000225992.8
PPY
pancreatic polypeptide
chr1_-_160262522 0.19 ENST00000440682.5
DCAF8
DDB1 and CUL4 associated factor 8
chr3_+_184338826 0.19 ENST00000453072.5
FAM131A
family with sequence similarity 131 member A
chr1_-_160262501 0.19 ENST00000447377.5
DCAF8
DDB1 and CUL4 associated factor 8
chr6_+_16129077 0.19 ENST00000356840.8
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr13_-_51974775 0.18 ENST00000674147.1
ATP7B
ATPase copper transporting beta
chr11_-_27700472 0.16 ENST00000418212.5
ENST00000533246.5
BDNF
brain derived neurotrophic factor
chr18_-_49557 0.16 ENST00000308911.8
TUBB8B
tubulin beta 8B
chr11_-_27700447 0.15 ENST00000356660.9
BDNF
brain derived neurotrophic factor
chr5_-_124746630 0.15 ENST00000513986.2
ZNF608
zinc finger protein 608
chr12_-_122395422 0.14 ENST00000540304.6
CLIP1
CAP-Gly domain containing linker protein 1
chr14_+_88385643 0.14 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chr1_+_171557845 0.13 ENST00000644916.1
PRRC2C
proline rich coiled-coil 2C
chr21_+_44646414 0.13 ENST00000334670.9
KRTAP10-11
keratin associated protein 10-11
chr1_+_159171607 0.12 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr14_+_88385714 0.12 ENST00000045347.11
SPATA7
spermatogenesis associated 7
chr6_-_158999748 0.11 ENST00000449822.5
RSPH3
radial spoke head 3
chr1_-_217076889 0.11 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr5_+_146203544 0.11 ENST00000506502.2
ENSG00000275740.1
novel readthrough transcript
chr14_-_59630806 0.11 ENST00000342503.8
RTN1
reticulon 1
chr19_-_47555856 0.11 ENST00000391901.7
ENST00000314121.8
ZNF541
zinc finger protein 541
chr14_-_59630582 0.10 ENST00000395090.5
RTN1
reticulon 1
chr6_-_159000174 0.10 ENST00000367069.7
RSPH3
radial spoke head 3
chr2_-_24971900 0.10 ENST00000264711.7
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr14_+_63761836 0.10 ENST00000674003.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr2_-_24972032 0.10 ENST00000534855.5
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr2_-_151261839 0.10 ENST00000331426.6
RBM43
RNA binding motif protein 43
chr7_+_100119607 0.10 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr1_-_170074568 0.09 ENST00000367767.5
ENST00000361580.7
ENST00000538366.5
KIFAP3
kinesin associated protein 3
chr6_+_96563117 0.08 ENST00000450218.6
FHL5
four and a half LIM domains 5
chr12_-_116881062 0.07 ENST00000550505.5
HRK
harakiri, BCL2 interacting protein
chr11_+_73308237 0.07 ENST00000263674.4
ARHGEF17
Rho guanine nucleotide exchange factor 17
chr17_-_43661915 0.07 ENST00000318579.9
ENST00000393661.2
MEOX1
mesenchyme homeobox 1
chr5_+_146203593 0.07 ENST00000265271.7
RBM27
RNA binding motif protein 27
chr4_+_625555 0.07 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chrX_-_10833643 0.07 ENST00000380785.5
ENST00000380787.5
MID1
midline 1
chr8_-_17002327 0.07 ENST00000180166.6
FGF20
fibroblast growth factor 20
chrX_+_10156960 0.06 ENST00000380833.9
CLCN4
chloride voltage-gated channel 4
chr2_-_179049986 0.06 ENST00000409284.1
ENST00000443758.6
ENST00000446116.5
CCDC141
coiled-coil domain containing 141
chr1_-_160262540 0.06 ENST00000368074.6
DCAF8
DDB1 and CUL4 associated factor 8
chr10_-_73625951 0.06 ENST00000433394.1
ENST00000422491.7
USP54
ubiquitin specific peptidase 54
chr2_-_49973939 0.05 ENST00000630656.1
NRXN1
neurexin 1
chr2_-_157325808 0.05 ENST00000410096.6
ENST00000420719.6
ENST00000409216.5
ENST00000419116.2
ERMN
ermin
chr13_+_29428709 0.05 ENST00000542829.1
MTUS2
microtubule associated scaffold protein 2
chr1_+_62597510 0.05 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr5_+_140700437 0.05 ENST00000274712.8
ZMAT2
zinc finger matrin-type 2
chr1_-_160262407 0.05 ENST00000419626.1
ENST00000610139.5
ENST00000475733.5
ENST00000407642.6
ENST00000368073.7
ENST00000326837.6
DCAF8
DDB1 and CUL4 associated factor 8
chr7_-_78771108 0.05 ENST00000626691.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr13_-_99258366 0.05 ENST00000397470.5
ENST00000397473.7
GPR18
G protein-coupled receptor 18
chr12_+_401621 0.05 ENST00000412006.6
ENST00000239830.9
CCDC77
coiled-coil domain containing 77
chr14_+_31561376 0.05 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr9_-_21031614 0.04 ENST00000495827.3
HACD4
3-hydroxyacyl-CoA dehydratase 4
chr10_+_91923762 0.04 ENST00000265990.11
BTAF1
B-TFIID TATA-box binding protein associated factor 1
chr10_-_49269 0.04 ENST00000562809.1
ENST00000568866.5
ENST00000561967.1
ENST00000568584.6
TUBB8
tubulin beta 8 class VIII
chr7_-_78771265 0.04 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_-_24706622 0.04 ENST00000680286.1
ARHGAP21
Rho GTPase activating protein 21
chr6_+_33204645 0.03 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr3_-_142448060 0.03 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr13_-_49444004 0.03 ENST00000410043.5
ENST00000409308.6
CAB39L
calcium binding protein 39 like
chr3_-_142448028 0.03 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr10_+_47322450 0.03 ENST00000581492.3
GDF2
growth differentiation factor 2
chr4_-_184649436 0.03 ENST00000308394.9
ENST00000517513.5
ENST00000447121.2
ENST00000393588.8
ENST00000523916.5
CASP3
caspase 3
chr20_-_49913693 0.02 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr13_+_102799322 0.02 ENST00000639132.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr19_-_55580829 0.02 ENST00000592239.1
ENST00000325421.7
ZNF579
zinc finger protein 579
chr2_+_135741814 0.02 ENST00000272638.14
UBXN4
UBX domain protein 4
chr1_+_161766282 0.02 ENST00000680688.1
ATF6
activating transcription factor 6
chr16_-_740980 0.02 ENST00000251588.7
CIAO3
cytosolic iron-sulfur assembly component 3
chr16_-_740934 0.02 ENST00000540986.5
CIAO3
cytosolic iron-sulfur assembly component 3
chr19_-_37172670 0.02 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
ZNF585A
zinc finger protein 585A
chr10_+_100535927 0.02 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr19_-_37172432 0.02 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr1_-_17045219 0.01 ENST00000491274.5
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr14_+_22040576 0.01 ENST00000390448.3
TRAV20
T cell receptor alpha variable 20
chr11_+_1099730 0.01 ENST00000674892.1
MUC2
mucin 2, oligomeric mucus/gel-forming
chr10_-_100529854 0.01 ENST00000370320.4
ENST00000299166.9
ENST00000370322.5
NDUFB8
NADH:ubiquinone oxidoreductase subunit B8
chr1_-_41242106 0.01 ENST00000337495.9
ENST00000372597.5
ENST00000372596.5
SCMH1
Scm polycomb group protein homolog 1
chr13_+_27251569 0.01 ENST00000272274.8
ENST00000319826.8
ENST00000326092.8
RPL21
ribosomal protein L21
chr13_-_30464234 0.01 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr18_-_26091175 0.00 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chrX_-_77895414 0.00 ENST00000618282.5
ENST00000373336.3
MAGT1
magnesium transporter 1
chr10_+_120851341 0.00 ENST00000263461.11
WDR11
WD repeat domain 11
chr9_-_83978429 0.00 ENST00000351839.7
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr8_-_80171106 0.00 ENST00000519303.6
TPD52
tumor protein D52
chr6_-_43014254 0.00 ENST00000642748.1
MEA1
male-enhanced antigen 1
chr7_-_100119323 0.00 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr14_+_20190896 0.00 ENST00000641879.2
ENST00000641682.1
OR11G2
olfactory receptor family 11 subfamily G member 2
chr8_-_20183090 0.00 ENST00000265808.11
ENST00000522513.5
SLC18A1
solute carrier family 18 member A1
chrX_-_143635081 0.00 ENST00000338017.8
SLITRK4
SLIT and NTRK like family member 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.1 0.2 GO:0060003 copper ion export(GO:0060003)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.1 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.1 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.1 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.2 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)