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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for CDC5L
Z-value: 0.71
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Transcription factors associated with CDC5L
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDC5L | hg38_v1_chr6_+_44387686_44387730 | 0.11 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDC5L
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.1 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.0 | 3.3 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.3 | 3.1 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.0 | 2.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.5 | 2.0 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.6 | 1.7 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.5 | 1.5 | GO:0045897 | positive regulation of transcription during mitosis(GO:0045897) |
| 0.1 | 1.5 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.0 | 1.5 | GO:0030449 | regulation of complement activation(GO:0030449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.8 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.7 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 1.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 1.7 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 1.6 | GO:0097433 | dense body(GO:0097433) |
| 0.4 | 1.5 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.2 | 1.1 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.1 | 1.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 1.1 | GO:0031527 | filopodium membrane(GO:0031527) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.6 | 5.1 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.2 | 5.1 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 2.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 1.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.3 | 1.7 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 1.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 1.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 1.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 1.4 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.5 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 5.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 2.4 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.5 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 1.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.4 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.0 | 1.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |