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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for CEBPA
Z-value: 1.14
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg38_v1_chr19_-_33302524_33302542 | 0.22 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102798148 Show fit | 2.71 |
ENST00000315274.7
|
matrix metallopeptidase 1 |
|
| chr13_+_95433593 Show fit | 2.59 |
ENST00000376873.7
|
claudin 10 |
|
| chr16_-_55833085 Show fit | 2.17 |
ENST00000360526.8
|
carboxylesterase 1 |
|
| chr18_-_63644250 Show fit | 2.00 |
ENST00000341074.10
ENST00000436264.1 |
serpin family B member 4 |
|
| chr1_-_153375591 Show fit | 1.83 |
ENST00000368737.5
|
S100 calcium binding protein A12 |
|
| chr19_-_54364983 Show fit | 1.80 |
ENST00000434277.6
|
leukocyte associated immunoglobulin like receptor 1 |
|
| chr15_-_74203172 Show fit | 1.70 |
ENST00000616000.4
|
signaling receptor and transporter of retinol STRA6 |
|
| chr8_-_6877928 Show fit | 1.70 |
ENST00000297439.4
|
defensin beta 1 |
|
| chr13_-_20230970 Show fit | 1.69 |
ENST00000644667.1
ENST00000646108.1 |
gap junction protein beta 6 |
|
| chr2_+_227813834 Show fit | 1.67 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.9 | 3.7 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.5 | 2.9 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.1 | 2.7 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.1 | 2.6 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.4 | 2.5 | GO:0010166 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.1 | 2.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.7 | 2.2 | GO:0010933 | macrophage tolerance induction(GO:0010931) regulation of macrophage tolerance induction(GO:0010932) positive regulation of macrophage tolerance induction(GO:0010933) |
| 0.7 | 2.0 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.0 | 2.0 | GO:0050832 | defense response to fungus(GO:0050832) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 4.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 3.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 2.5 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 2.2 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 1.7 | GO:1990742 | microvesicle(GO:1990742) |
| 0.1 | 1.7 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 1.6 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 4.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.7 | 3.7 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 1.1 | 3.4 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 2.9 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.0 | 2.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 2.5 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.0 | 2.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.6 | 1.9 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 0.1 | 1.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 3.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 3.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 3.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 2.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 2.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.0 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 1.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 1.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |