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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DLX5

Z-value: 0.58

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.7 DLX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg38_v1_chr7_-_97024821_970249500.193.2e-01Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_6904733 3.75 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
LRRC23
leucine rich repeat containing 23
chr13_+_35476740 3.43 ENST00000537702.5
NBEA
neurobeachin
chr3_-_180679468 3.38 ENST00000651046.1
ENST00000476379.6
CCDC39
coiled-coil domain containing 39
chr12_+_6904962 2.98 ENST00000415834.5
ENST00000436789.5
LRRC23
leucine rich repeat containing 23
chr2_+_227871618 2.94 ENST00000309931.3
ENST00000440997.1
DAW1
dynein assembly factor with WD repeats 1
chr16_+_53099100 1.70 ENST00000565832.5
CHD9
chromodomain helicase DNA binding protein 9
chr5_-_160852200 1.37 ENST00000327245.10
ATP10B
ATPase phospholipid transporting 10B (putative)
chr4_+_76435216 1.26 ENST00000296043.7
SHROOM3
shroom family member 3
chr11_-_26572254 1.21 ENST00000529533.6
MUC15
mucin 15, cell surface associated
chrX_-_152830721 1.18 ENST00000370277.5
CETN2
centrin 2
chr3_+_186842687 1.17 ENST00000444204.2
ENST00000320741.7
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr10_+_114043858 1.15 ENST00000369295.4
ADRB1
adrenoceptor beta 1
chr19_+_49513353 1.01 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr11_-_33892010 0.99 ENST00000257818.3
LMO2
LIM domain only 2
chr11_-_26572130 0.99 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr18_-_55588184 0.91 ENST00000354452.8
ENST00000565908.6
ENST00000635822.2
TCF4
transcription factor 4
chr18_-_55587335 0.90 ENST00000638154.3
TCF4
transcription factor 4
chr1_-_23344259 0.88 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_23344314 0.85 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr7_-_130441136 0.77 ENST00000675596.1
ENST00000676312.1
CEP41
centrosomal protein 41
chr11_+_124183219 0.77 ENST00000641351.2
OR10D3
olfactory receptor family 10 subfamily D member 3
chr4_-_145180496 0.62 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr15_+_89088417 0.62 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
ABHD2
abhydrolase domain containing 2, acylglycerol lipase
chr7_+_100119607 0.61 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr5_-_20575850 0.58 ENST00000507958.5
CDH18
cadherin 18
chr7_+_71132123 0.57 ENST00000333538.10
GALNT17
polypeptide N-acetylgalactosaminyltransferase 17
chr16_+_590056 0.55 ENST00000248139.8
ENST00000568586.5
ENST00000538492.5
RAB40C
RAB40C, member RAS oncogene family
chr7_-_87220567 0.52 ENST00000433078.5
TMEM243
transmembrane protein 243
chr17_+_45161070 0.52 ENST00000593138.6
ENST00000586681.6
HEXIM2
HEXIM P-TEFb complex subunit 2
chr3_+_2892199 0.51 ENST00000397459.6
CNTN4
contactin 4
chr1_-_150697128 0.51 ENST00000427665.1
ENST00000271732.8
GOLPH3L
golgi phosphoprotein 3 like
chr3_-_186570308 0.48 ENST00000446782.5
TBCCD1
TBCC domain containing 1
chr19_-_36114850 0.47 ENST00000221859.9
POLR2I
RNA polymerase II subunit I
chr9_-_134068012 0.44 ENST00000303407.12
BRD3
bromodomain containing 3
chr6_-_77463485 0.42 ENST00000369947.5
HTR1B
5-hydroxytryptamine receptor 1B
chr19_+_6372757 0.40 ENST00000245812.8
ALKBH7
alkB homolog 7
chr15_+_41621134 0.39 ENST00000566718.6
MGA
MAX dimerization protein MGA
chr14_+_22271921 0.37 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr15_+_41621492 0.36 ENST00000570161.6
MGA
MAX dimerization protein MGA
chr11_+_818906 0.36 ENST00000336615.9
PNPLA2
patatin like phospholipase domain containing 2
chr12_+_52301833 0.34 ENST00000293525.5
KRT86
keratin 86
chr19_+_1266653 0.34 ENST00000586472.5
ENST00000589266.5
CIRBP
cold inducible RNA binding protein
chr2_+_168901290 0.34 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr4_-_65670478 0.33 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chr14_-_67816574 0.32 ENST00000677026.1
ENST00000555452.1
ENST00000347230.9
ENST00000678386.1
ENST00000676620.1
ENST00000676512.1
ZFYVE26
zinc finger FYVE-type containing 26
chr1_-_92486916 0.31 ENST00000294702.6
GFI1
growth factor independent 1 transcriptional repressor
chr1_+_100538131 0.30 ENST00000315033.5
GPR88
G protein-coupled receptor 88
chr5_-_59276109 0.28 ENST00000503258.5
PDE4D
phosphodiesterase 4D
chr4_-_65670339 0.27 ENST00000273854.7
EPHA5
EPH receptor A5
chr14_-_23551729 0.27 ENST00000419474.5
ZFHX2
zinc finger homeobox 2
chr19_-_45782388 0.24 ENST00000458663.6
DMPK
DM1 protein kinase
chr14_+_95535008 0.21 ENST00000331334.5
GLRX5
glutaredoxin 5
chr5_+_64505981 0.18 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr2_+_169584779 0.17 ENST00000678638.1
PPIG
peptidylprolyl isomerase G
chr6_-_33289189 0.17 ENST00000374617.9
WDR46
WD repeat domain 46
chr7_-_7535863 0.17 ENST00000399429.8
COL28A1
collagen type XXVIII alpha 1 chain
chr2_+_95297304 0.16 ENST00000295225.10
KCNIP3
potassium voltage-gated channel interacting protein 3
chr21_-_30881572 0.16 ENST00000332378.6
KRTAP11-1
keratin associated protein 11-1
chr17_+_44187210 0.16 ENST00000589785.1
ENST00000592825.1
ENST00000589184.5
TMUB2
transmembrane and ubiquitin like domain containing 2
chr4_-_137532452 0.15 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
PCDH18
protocadherin 18
chr6_-_27893175 0.15 ENST00000359611.4
H2AC17
H2A clustered histone 17
chr7_-_100119840 0.15 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr17_+_75110021 0.15 ENST00000584947.1
ARMC7
armadillo repeat containing 7
chr10_-_49762335 0.14 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr17_+_44187190 0.14 ENST00000319511.6
TMUB2
transmembrane and ubiquitin like domain containing 2
chr19_-_46634685 0.13 ENST00000300873.4
GNG8
G protein subunit gamma 8
chr12_+_51424802 0.13 ENST00000453097.7
SLC4A8
solute carrier family 4 member 8
chr11_+_76381303 0.13 ENST00000662483.1
ENST00000663165.1
ENST00000529331.2
ENST00000321844.6
ENST00000667240.1
GVQW3
GVQW motif containing 3
chr6_-_41733690 0.13 ENST00000419396.6
ENST00000678831.1
ENST00000394283.5
TFEB
transcription factor EB
chr11_-_94973541 0.12 ENST00000279839.8
CWC15
CWC15 spliceosome associated protein homolog
chr12_+_51424965 0.11 ENST00000514353.7
SLC4A8
solute carrier family 4 member 8
chr8_+_91249307 0.11 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chrX_-_16869840 0.11 ENST00000380084.8
RBBP7
RB binding protein 7, chromatin remodeling factor
chr22_-_30564889 0.10 ENST00000401975.5
ENST00000428682.5
ENST00000423299.5
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_160190567 0.10 ENST00000368078.8
CASQ1
calsequestrin 1
chr10_-_49762276 0.10 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr10_-_54801262 0.09 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
PCDH15
protocadherin related 15
chr11_+_57667974 0.07 ENST00000528177.5
ENST00000287169.8
ZDHHC5
zinc finger DHHC-type palmitoyltransferase 5
chr3_+_186570663 0.07 ENST00000265028.8
DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
chr10_-_54801221 0.07 ENST00000644397.2
ENST00000395445.6
ENST00000613657.5
ENST00000320301.11
PCDH15
protocadherin related 15
chr12_+_53985138 0.07 ENST00000303460.5
HOXC10
homeobox C10
chr12_-_56645955 0.07 ENST00000552959.5
ENST00000551020.5
ENST00000553007.2
ENST00000262030.8
ATP5F1B
ATP synthase F1 subunit beta
chr2_+_30146941 0.06 ENST00000379520.7
ENST00000379519.7
YPEL5
yippee like 5
chr7_-_30550761 0.06 ENST00000598361.4
ENST00000440438.6
ENSG00000281039.1
GARS1-DT
novel protein
GARS1 divergent transcript
chrX_+_101391000 0.06 ENST00000553110.8
ENST00000409338.5
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr2_+_30146993 0.06 ENST00000261353.9
ENST00000402003.7
YPEL5
yippee like 5
chr14_+_45135917 0.06 ENST00000267430.10
ENST00000556036.5
ENST00000542564.6
FANCM
FA complementation group M
chrX_+_101390976 0.05 ENST00000392994.7
RPL36A
ribosomal protein L36a
chr11_+_73787853 0.05 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr18_-_61892997 0.04 ENST00000312828.4
RNF152
ring finger protein 152
chr21_-_14546297 0.04 ENST00000400566.6
ENST00000400564.5
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_33192454 0.03 ENST00000395194.1
ENST00000341947.7
ENST00000374708.8
COL11A2
collagen type XI alpha 2 chain
chr19_+_4007714 0.03 ENST00000262971.3
PIAS4
protein inhibitor of activated STAT 4
chr10_-_95441015 0.02 ENST00000371241.5
ENST00000354106.7
ENST00000371239.5
ENST00000361941.7
ENST00000277982.9
ENST00000371245.7
SORBS1
sorbin and SH3 domain containing 1
chr9_+_34646589 0.01 ENST00000450095.6
GALT
galactose-1-phosphate uridylyltransferase
chr7_-_100119323 0.01 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chrX_+_101390824 0.01 ENST00000427805.6
ENST00000614077.4
RPL36A
ribosomal protein L36a
chr3_+_158801926 0.01 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr13_-_36214521 0.01 ENST00000379881.8
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr9_+_34646654 0.01 ENST00000378842.8
GALT
galactose-1-phosphate uridylyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 1.2 GO:2000584 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.4 1.2 GO:0003099 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.3 1.0 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.3 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.4 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1 1.3 GO:0045176 apical protein localization(GO:0045176)
0.1 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.8 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.7 GO:0061157 mRNA destabilization(GO:0061157)
0.1 0.3 GO:0061743 motor learning(GO:0061743)
0.0 0.5 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 1.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.0 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 1.2 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898) acylglycerol acyl-chain remodeling(GO:0036155)
0.0 2.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.6 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.6 GO:0048240 sperm capacitation(GO:0048240)
0.0 2.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.5 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.5 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0071942 XPC complex(GO:0071942)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 3.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.9 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 1.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.8 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.0 GO:0005592 collagen type XI trimer(GO:0005592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.3 1.0 GO:0019770 IgG receptor activity(GO:0019770)
0.2 1.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.3 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing