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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for DMC1

Z-value: 0.44

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.10 DMC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg38_v1_chr22_-_38570167_38570204-0.365.0e-02Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_95391361 2.12 ENST00000283357.10
FAM81B
family with sequence similarity 81 member B
chr7_-_5970632 1.43 ENST00000455618.2
ENST00000405415.5
ENST00000404406.5
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B
chr7_+_6754109 1.25 ENST00000403107.5
ENST00000404077.5
ENST00000435395.5
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2
chr4_+_15469865 1.14 ENST00000515124.6
ENST00000512702.6
ENST00000503292.6
ENST00000424120.6
ENST00000507954.5
ENST00000514450.3
ENST00000503658.2
CC2D2A
coiled-coil and C2 domain containing 2A
chr10_-_27983103 1.07 ENST00000672841.1
ODAD2
outer dynein arm docking complex subunit 2
chr21_-_44928824 1.03 ENST00000355153.8
ENST00000397850.6
ITGB2
integrin subunit beta 2
chr11_+_71527267 0.69 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chrX_+_106611930 0.61 ENST00000372544.6
ENST00000372548.9
RADX
RPA1 related single stranded DNA binding protein, X-linked
chr11_+_134331874 0.59 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr11_+_101914997 0.55 ENST00000263468.13
CEP126
centrosomal protein 126
chr10_+_73110494 0.54 ENST00000372997.3
NUDT13
nudix hydrolase 13
chr10_+_73110375 0.52 ENST00000617744.4
ENST00000544879.5
ENST00000537969.5
ENST00000357321.9
ENST00000349051.9
NUDT13
nudix hydrolase 13
chr10_-_60572599 0.51 ENST00000503366.5
ANK3
ankyrin 3
chr7_+_92057602 0.50 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr2_+_119429889 0.45 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr11_+_6863057 0.45 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr20_-_21397513 0.42 ENST00000351817.5
NKX2-4
NK2 homeobox 4
chr1_+_166989089 0.32 ENST00000367870.6
MAEL
maelstrom spermatogenic transposon silencer
chr2_-_162152404 0.31 ENST00000375497.3
GCG
glucagon
chr17_+_79022814 0.30 ENST00000578229.5
C1QTNF1
C1q and TNF related 1
chr2_-_162152239 0.30 ENST00000418842.7
GCG
glucagon
chrX_-_135171398 0.29 ENST00000276241.11
ENST00000344129.2
CT55
cancer/testis antigen 55
chr3_-_108953870 0.29 ENST00000261047.8
GUCA1C
guanylate cyclase activator 1C
chr1_+_166989254 0.29 ENST00000367872.9
ENST00000447624.1
MAEL
maelstrom spermatogenic transposon silencer
chr3_-_108953762 0.28 ENST00000393963.7
ENST00000471108.1
GUCA1C
guanylate cyclase activator 1C
chr10_+_60778331 0.26 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr3_+_98353854 0.26 ENST00000354924.2
OR5K4
olfactory receptor family 5 subfamily K member 4
chr14_+_73851908 0.26 ENST00000267568.8
PTGR2
prostaglandin reductase 2
chr10_+_60778490 0.25 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr14_+_73851809 0.25 ENST00000555661.6
ENST00000555228.5
PTGR2
prostaglandin reductase 2
chr2_-_18560616 0.23 ENST00000381249.4
RDH14
retinol dehydrogenase 14
chr4_+_105552611 0.23 ENST00000265154.6
ENST00000420470.3
ARHGEF38
Rho guanine nucleotide exchange factor 38
chr10_-_73096974 0.22 ENST00000440381.5
ENST00000263556.3
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr10_-_73096850 0.19 ENST00000307116.6
ENST00000373008.6
ENST00000394890.7
P4HA1
prolyl 4-hydroxylase subunit alpha 1
chr9_-_34729482 0.18 ENST00000378788.4
FAM205A
family with sequence similarity 205 member A
chr17_+_79022908 0.14 ENST00000354124.7
ENST00000580454.5
C1QTNF1
C1q and TNF related 1
chr5_-_150086511 0.14 ENST00000675795.1
CSF1R
colony stimulating factor 1 receptor
chr1_+_12230006 0.13 ENST00000620676.6
VPS13D
vacuolar protein sorting 13 homolog D
chr1_+_12230064 0.13 ENST00000613099.4
VPS13D
vacuolar protein sorting 13 homolog D
chr12_-_70637405 0.11 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
PTPRB
protein tyrosine phosphatase receptor type B
chr7_+_144070313 0.10 ENST00000641441.1
OR2A25
olfactory receptor family 2 subfamily A member 25
chr11_-_86069043 0.10 ENST00000532317.5
ENST00000528256.1
ENST00000393346.8
ENST00000526033.5
PICALM
phosphatidylinositol binding clathrin assembly protein
chr10_-_96271553 0.10 ENST00000224337.10
BLNK
B cell linker
chr21_-_36980789 0.09 ENST00000675307.1
ENST00000612277.4
HLCS
holocarboxylase synthetase
chr1_-_46665849 0.09 ENST00000532925.5
ENST00000542495.5
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr12_-_53507482 0.09 ENST00000267017.4
ENST00000448979.4
NPFF
neuropeptide FF-amide peptide precursor
chr17_+_4942805 0.09 ENST00000576965.1
RNF167
ring finger protein 167
chr2_+_218382265 0.08 ENST00000233202.11
SLC11A1
solute carrier family 11 member 1
chr2_-_20823048 0.08 ENST00000402479.6
ENST00000237822.8
ENST00000626491.2
ENST00000432947.1
ENST00000403006.6
ENST00000419825.2
ENST00000381090.7
ENST00000412261.5
ENST00000619656.4
ENST00000541941.5
ENST00000440866.6
ENST00000435420.6
LDAH
lipid droplet associated hydrolase
chr10_-_96271508 0.08 ENST00000427367.6
ENST00000413476.6
ENST00000371176.6
BLNK
B cell linker
chr11_-_86068929 0.08 ENST00000630913.2
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_-_46812558 0.07 ENST00000641183.1
ENST00000460241.2
ENSG00000284672.1
ENSG00000206549.13
novel transcript
novel protein identical to PRSS50
chrX_-_153470555 0.07 ENST00000370211.10
ENST00000330912.7
ENST00000334497.7
ENST00000338525.7
ENST00000370232.4
HAUS7
TREX2
HAUS augmin like complex subunit 7
three prime repair exonuclease 2
chr15_+_41286011 0.07 ENST00000661438.1
ENSG00000285920.2
novel protein
chr14_-_21023318 0.06 ENST00000298684.9
ENST00000557169.5
ENST00000553563.5
NDRG2
NDRG family member 2
chr6_-_31702946 0.06 ENST00000440843.2
ABHD16A
abhydrolase domain containing 16A, phospholipase
chr10_+_17809337 0.05 ENST00000569591.3
MRC1
mannose receptor C-type 1
chr6_+_87344812 0.05 ENST00000388923.5
C6orf163
chromosome 6 open reading frame 163
chr1_-_11803383 0.05 ENST00000641407.1
ENST00000376583.7
ENST00000423400.7
MTHFR
methylenetetrahydrofolate reductase
chr5_-_83673544 0.04 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr7_-_15561986 0.04 ENST00000342526.8
AGMO
alkylglycerol monooxygenase
chr7_-_151187212 0.03 ENST00000420175.3
ENST00000275838.5
ASB10
ankyrin repeat and SOCS box containing 10
chr10_+_68106109 0.03 ENST00000540630.5
ENST00000354393.6
MYPN
myopalladin
chrX_+_66162663 0.03 ENST00000519389.6
HEPH
hephaestin
chr17_-_62065248 0.03 ENST00000397786.7
MED13
mediator complex subunit 13
chr16_+_2205708 0.02 ENST00000397124.5
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog
chr6_+_116461364 0.02 ENST00000368606.7
ENST00000368605.3
CALHM6
calcium homeostasis modulator family member 6
chr2_+_186590022 0.02 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr7_-_151187772 0.02 ENST00000377867.7
ASB10
ankyrin repeat and SOCS box containing 10
chr5_-_135895834 0.01 ENST00000274520.2
IL9
interleukin 9
chr6_-_62286161 0.01 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr11_-_62921339 0.00 ENST00000306960.4
CHRM1
cholinergic receptor muscarinic 1
chr20_+_2816302 0.00 ENST00000361033.1
TMEM239
transmembrane protein 239
chr5_+_55853528 0.00 ENST00000490985.5
IL31RA
interleukin 31 receptor A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.5 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.5 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
0.1 0.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.6 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.9 GO:0097242 beta-amyloid clearance(GO:0097242)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0009305 protein biotinylation(GO:0009305) histone biotinylation(GO:0071110)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.1 GO:0070253 somatostatin secretion(GO:0070253)
0.0 1.1 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0030849 autosome(GO:0030849)
0.1 0.4 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 0.8 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 1.1 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 0.6 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.5 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.6 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0004079 biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins