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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for E2F2_E2F5
Z-value: 2.31
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Transcription factors associated with E2F2_E2F5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F2 | hg38_v1_chr1_-_23531206_23531241 | 0.69 | 2.7e-05 | Click! |
| E2F5 | hg38_v1_chr8_+_85209213_85209270 | -0.30 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F2_E2F5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 49.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 3.0 | 32.6 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 2.4 | 28.2 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.9 | 25.8 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.5 | 23.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.4 | 19.9 | GO:0035825 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 2.5 | 19.7 | GO:0090166 | regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166) |
| 3.6 | 18.0 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.2 | 15.8 | GO:0019985 | translesion synthesis(GO:0019985) |
| 1.3 | 15.6 | GO:1902969 | mitotic DNA replication(GO:1902969) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 48.7 | GO:0042555 | MCM complex(GO:0042555) |
| 5.2 | 25.8 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 24.8 | GO:0005874 | microtubule(GO:0005874) |
| 0.7 | 19.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 4.9 | 19.7 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 3.6 | 14.3 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 13.4 | GO:0005813 | centrosome(GO:0005813) |
| 1.2 | 13.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.5 | 11.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.6 | 11.7 | GO:0045120 | pronucleus(GO:0045120) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.7 | 30.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 5.2 | 25.8 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.3 | 22.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 4.4 | 21.9 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 0.9 | 19.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 18.2 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 15.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.0 | 15.0 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 1.1 | 14.3 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 39.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 38.6 | PID ATR PATHWAY | ATR signaling pathway |
| 1.4 | 28.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.7 | 24.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 10.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 9.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 8.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 8.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 6.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 6.1 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 69.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 3.7 | 62.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.9 | 33.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.1 | 17.0 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 1.3 | 15.4 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.2 | 10.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.2 | 8.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 7.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.5 | 7.3 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.2 | 6.1 | REACTOME KINESINS | Genes involved in Kinesins |