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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for E2F7_E2F1
Z-value: 3.39
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg38_v1_chr12_-_77065526_77065586 | 0.73 | 4.2e-06 | Click! |
| E2F1 | hg38_v1_chr20_-_33686371_33686407 | 0.50 | 4.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 40.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.3 | 35.1 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 4.3 | 34.3 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 3.2 | 28.6 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.7 | 27.5 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
| 0.7 | 27.0 | GO:0034080 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.7 | 26.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 7.9 | 23.8 | GO:0036333 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 7.8 | 23.4 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 3.9 | 19.6 | GO:0019087 | transformation of host cell by virus(GO:0019087) uracil metabolic process(GO:0019860) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 51.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.5 | 39.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.7 | 31.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 6.2 | 31.0 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.5 | 28.9 | GO:0045120 | pronucleus(GO:0045120) |
| 3.2 | 26.0 | GO:0000796 | condensin complex(GO:0000796) |
| 0.3 | 22.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.2 | 21.5 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 20.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 19.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 47.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 6.2 | 31.0 | GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 30.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 5.9 | 29.5 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 2.1 | 27.1 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 1.8 | 25.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 2.7 | 21.7 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 1.4 | 20.5 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.2 | 18.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 18.2 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 131.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.8 | 40.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.5 | 21.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 19.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 19.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 16.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 16.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 13.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 8.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.3 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 72.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 3.8 | 63.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.3 | 30.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 2.1 | 30.0 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 1.3 | 26.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 1.4 | 21.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 18.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.5 | 17.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 17.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.9 | 17.1 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |