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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for E2F8
Z-value: 1.38
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Transcription factors associated with E2F8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F8 | hg38_v1_chr11_-_19241598_19241628, hg38_v1_chr11_-_19240936_19240968 | 0.72 | 7.9e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 1.0 | 10.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.3 | 9.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 2.2 | 9.0 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.7 | 9.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 6.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.8 | 5.4 | GO:0031938 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 0.7 | 5.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 1.5 | 4.4 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.9 | 4.4 | GO:0002317 | plasma cell differentiation(GO:0002317) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.8 | 13.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 11.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.9 | 9.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.7 | 8.7 | GO:0031523 | Myb complex(GO:0031523) |
| 0.3 | 8.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 6.5 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.2 | 5.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 1.8 | 5.4 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 0.9 | 5.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 1.9 | 9.5 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 2.2 | 9.0 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.1 | 8.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 1.4 | 6.8 | GO:0030395 | lactose binding(GO:0030395) |
| 0.1 | 6.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 5.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 1.0 | 5.2 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.7 | 4.4 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 11.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 10.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 8.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 6.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 2.9 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 19.0 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.4 | 9.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.5 | 8.7 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.3 | 7.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 6.4 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.1 | 3.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 3.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 3.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 3.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |