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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ELF2_GABPA_ELF5
Z-value: 1.89
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Transcription factors associated with ELF2_GABPA_ELF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF2 | hg38_v1_chr4_-_139084289_139084496 | 0.57 | 1.1e-03 | Click! |
| ELF5 | hg38_v1_chr11_-_34511710_34511799 | 0.54 | 2.3e-03 | Click! |
| GABPA | hg38_v1_chr21_+_25734948_25734988 | 0.04 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 32.8 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.4 | 19.3 | GO:0035082 | axoneme assembly(GO:0035082) |
| 3.8 | 18.8 | GO:0002386 | immune response in mucosal-associated lymphoid tissue(GO:0002386) |
| 2.3 | 16.0 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.1 | 15.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.6 | 14.9 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.1 | 12.0 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.8 | 11.9 | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) |
| 0.3 | 11.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 11.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 1.2 | 23.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 18.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 1.8 | 17.8 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.2 | 17.3 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.7 | 17.2 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 17.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.0 | 13.7 | GO:0034464 | BBSome(GO:0034464) |
| 0.4 | 13.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.3 | 11.3 | GO:0032040 | small-subunit processome(GO:0032040) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.9 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 24.2 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
| 0.5 | 20.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.6 | 20.0 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.4 | 13.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.2 | 11.5 | GO:0008374 | O-acyltransferase activity(GO:0008374) |
| 0.3 | 10.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 10.2 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.2 | 9.9 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 9.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 11.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 7.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 7.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 7.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 7.0 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 5.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 5.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 4.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 19.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.6 | 15.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 11.7 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 11.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 9.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 8.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 7.5 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.1 | 6.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 6.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |