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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for EPAS1_BCL3
Z-value: 1.27
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Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg38_v1_chr2_+_46297397_46297414 | -0.23 | 2.2e-01 | Click! |
| BCL3 | hg38_v1_chr19_+_44751251_44751321 | -0.18 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_40351026 Show fit | 1.92 |
ENST00000448599.2
|
proline, histidine and glycine rich 1 |
|
| chr7_+_154305256 Show fit | 1.89 |
ENST00000619756.4
|
dipeptidyl peptidase like 6 |
|
| chr12_+_56021316 Show fit | 1.67 |
ENST00000547791.2
|
IKAROS family zinc finger 4 |
|
| chr3_-_116444983 Show fit | 1.43 |
ENST00000333617.8
|
limbic system associated membrane protein |
|
| chr20_-_2800576 Show fit | 1.39 |
ENST00000380605.3
|
carboxypeptidase X, M14 family member 1 |
|
| chr20_-_45115149 Show fit | 1.38 |
ENST00000307971.7
ENST00000372789.5 |
WAP four-disulfide core domain 5 |
|
| chr16_+_82626955 Show fit | 1.34 |
ENST00000268613.14
ENST00000567109.6 ENST00000565636.5 ENST00000431540.7 ENST00000428848.7 |
cadherin 13 |
|
| chr1_+_158254414 Show fit | 1.28 |
ENST00000289429.6
|
CD1a molecule |
|
| chr19_+_35138778 Show fit | 1.22 |
ENST00000351325.9
ENST00000586871.5 ENST00000592174.1 |
FXYD domain containing ion transport regulator 1 novel transcript |
|
| chr1_+_152514474 Show fit | 1.19 |
ENST00000368790.4
|
cysteine rich C-terminal 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.2 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.0 | 2.6 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.1 | 2.3 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.2 | 2.2 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 2.2 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 2.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 1.5 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.2 | 1.4 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.2 | 1.3 | GO:0018916 | nitrobenzene metabolic process(GO:0018916) |
| 0.1 | 1.3 | GO:0055096 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 3.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 3.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 3.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 1.4 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 1.3 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.1 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 1.1 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 3.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 2.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 2.5 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 2.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.5 | 1.6 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 1.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.5 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.2 | 1.4 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.8 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 2.2 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 1.2 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.7 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.0 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 1.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |