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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ESR1
Z-value: 0.71
Motif logo
Transcription factors associated with ESR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ESR1
|
ENSG00000091831.24 | ESR1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR1 | hg38_v1_chr6_+_151809105_151809139 | 0.39 | 3.2e-02 | Click! |
Activity profile of ESR1 motif
Sorted Z-values of ESR1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ESR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.3 | 1.4 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.3 | 0.8 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.2 | 3.0 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.2 | 0.7 | GO:0014028 | notochord formation(GO:0014028) |
| 0.2 | 0.7 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.2 | 0.4 | GO:1904956 | Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.2 | 1.7 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.2 | 0.5 | GO:0002665 | negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017) |
| 0.2 | 1.2 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.2 | 1.0 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.2 | 0.8 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.2 | 0.9 | GO:1900104 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.1 | 0.4 | GO:0044335 | neural crest cell fate commitment(GO:0014034) canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335) |
| 0.1 | 0.7 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
| 0.1 | 0.6 | GO:1902283 | negative regulation of primary amine oxidase activity(GO:1902283) |
| 0.1 | 1.5 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.1 | 0.5 | GO:0030821 | negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) |
| 0.1 | 0.4 | GO:1900155 | regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155) |
| 0.1 | 2.4 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 0.6 | GO:0010193 | response to ozone(GO:0010193) |
| 0.1 | 0.4 | GO:0006045 | N-acetylglucosamine biosynthetic process(GO:0006045) glucosamine-containing compound biosynthetic process(GO:1901073) |
| 0.1 | 1.4 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.6 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 0.8 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.1 | 0.8 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.1 | 0.6 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) |
| 0.1 | 0.5 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 0.4 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.1 | 0.6 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.1 | 0.5 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.8 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 0.1 | 0.4 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.1 | 0.4 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 0.4 | GO:0042377 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.1 | 0.3 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
| 0.1 | 0.5 | GO:1902612 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 0.1 | 0.4 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.1 | 0.2 | GO:1902822 | regulation of late endosome to lysosome transport(GO:1902822) negative regulation of late endosome to lysosome transport(GO:1902823) |
| 0.1 | 0.5 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 0.3 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 0.1 | 0.3 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 0.1 | 0.2 | GO:0051885 | positive regulation of anagen(GO:0051885) |
| 0.1 | 0.3 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.1 | 0.2 | GO:0097212 | cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) positive regulation of late endosome to lysosome transport(GO:1902824) |
| 0.1 | 0.8 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.1 | 0.5 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 0.6 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.1 | 0.5 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.1 | 0.6 | GO:0072719 | cellular response to cisplatin(GO:0072719) |
| 0.1 | 0.2 | GO:0038193 | thromboxane A2 signaling pathway(GO:0038193) |
| 0.1 | 0.2 | GO:0009258 | 10-formyltetrahydrofolate catabolic process(GO:0009258) |
| 0.1 | 0.3 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 1.7 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.1 | 0.2 | GO:2000410 | regulation of thymocyte migration(GO:2000410) |
| 0.1 | 0.2 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 0.2 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.1 | 0.5 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.1 | 1.0 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 6.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.2 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.1 | 0.3 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.1 | 0.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 0.3 | GO:0071279 | negative regulation of mitochondrial fusion(GO:0010637) cellular response to cobalt ion(GO:0071279) |
| 0.0 | 0.3 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.0 | 0.2 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.0 | 1.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.1 | GO:0070894 | transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895) |
| 0.0 | 0.1 | GO:0042662 | negative regulation of mesodermal cell fate specification(GO:0042662) |
| 0.0 | 0.6 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.8 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.0 | 0.6 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.0 | 0.5 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.0 | 0.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.4 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.0 | 0.3 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.0 | 0.2 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.0 | 0.5 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.0 | 0.5 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
| 0.0 | 0.3 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.0 | 0.5 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.5 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.0 | 0.0 | GO:1904782 | negative regulation of glutamate receptor signaling pathway(GO:1900450) negative regulation of NMDA glutamate receptor activity(GO:1904782) |
| 0.0 | 0.6 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.5 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 0.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 0.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.2 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.2 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.0 | 0.6 | GO:2000543 | primitive streak formation(GO:0090009) positive regulation of gastrulation(GO:2000543) |
| 0.0 | 0.4 | GO:0043382 | positive regulation of memory T cell differentiation(GO:0043382) |
| 0.0 | 1.2 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.0 | 0.2 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.0 | 0.4 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.0 | 0.1 | GO:0072720 | response to dithiothreitol(GO:0072720) |
| 0.0 | 0.1 | GO:0003050 | regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050) |
| 0.0 | 0.2 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.0 | 0.8 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 0.3 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 0.1 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
| 0.0 | 0.6 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.4 | GO:0044821 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 0.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.3 | GO:1903416 | response to glycoside(GO:1903416) |
| 0.0 | 0.2 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.0 | 0.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.0 | 0.5 | GO:0015816 | glycine transport(GO:0015816) |
| 0.0 | 0.3 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.0 | 0.4 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 0.3 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.4 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.2 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 0.0 | 0.1 | GO:0048560 | establishment of anatomical structure orientation(GO:0048560) |
| 0.0 | 0.2 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.0 | 0.2 | GO:0021590 | cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699) |
| 0.0 | 0.2 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 0.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.2 | GO:2001184 | positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.0 | 0.8 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 1.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.3 | GO:0097396 | response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398) |
| 0.0 | 0.1 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
| 0.0 | 0.2 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.0 | 0.4 | GO:0090344 | negative regulation of cell aging(GO:0090344) |
| 0.0 | 0.1 | GO:1902559 | 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559) |
| 0.0 | 1.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 1.2 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.1 | GO:0002371 | dendritic cell cytokine production(GO:0002371) |
| 0.0 | 0.1 | GO:0071422 | succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) |
| 0.0 | 0.2 | GO:0046061 | dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061) |
| 0.0 | 0.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.1 | GO:0034499 | negative regulation of toll-like receptor 9 signaling pathway(GO:0034164) late endosome to Golgi transport(GO:0034499) |
| 0.0 | 4.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 0.1 | GO:0043380 | regulation of memory T cell differentiation(GO:0043380) |
| 0.0 | 0.6 | GO:0045821 | positive regulation of glycolytic process(GO:0045821) |
| 0.0 | 0.4 | GO:0042711 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 1.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.8 | GO:0031280 | negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280) |
| 0.0 | 0.2 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.0 | 0.2 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.0 | 0.1 | GO:0072526 | quinolinate metabolic process(GO:0046874) pyridine-containing compound catabolic process(GO:0072526) |
| 0.0 | 0.1 | GO:1901908 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.0 | 0.1 | GO:0070383 | DNA cytosine deamination(GO:0070383) |
| 0.0 | 1.0 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.0 | 0.3 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.2 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.0 | 0.3 | GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
| 0.0 | 0.1 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.0 | 0.1 | GO:2000360 | negative regulation of binding of sperm to zona pellucida(GO:2000360) |
| 0.0 | 0.2 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.1 | GO:0043652 | engulfment of apoptotic cell(GO:0043652) |
| 0.0 | 0.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.2 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 0.4 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 0.3 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 0.0 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.0 | 0.4 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.4 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.0 | 0.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 0.1 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 1.5 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 0.1 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.0 | 0.3 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 0.1 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.0 | 0.5 | GO:0048012 | hepatocyte growth factor receptor signaling pathway(GO:0048012) |
| 0.0 | 0.7 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 0.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 0.1 | GO:0050960 | detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594) |
| 0.0 | 0.1 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.0 | 0.2 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.0 | 0.1 | GO:0021936 | regulation of cerebellar granule cell precursor proliferation(GO:0021936) |
| 0.0 | 0.3 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.4 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.0 | 0.1 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.0 | 0.4 | GO:0060732 | regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 0.1 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.0 | 0.1 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.0 | 0.1 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.0 | 0.1 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
| 0.0 | 0.3 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.0 | 0.2 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.0 | 0.3 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.0 | 0.1 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.2 | GO:0009437 | carnitine metabolic process(GO:0009437) |
| 0.0 | 0.1 | GO:0042851 | L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853) |
| 0.0 | 0.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.3 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.0 | 0.4 | GO:0045907 | positive regulation of vasoconstriction(GO:0045907) |
| 0.0 | 0.3 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.0 | 0.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 0.1 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
| 0.0 | 0.2 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 0.0 | GO:0009305 | protein biotinylation(GO:0009305) response to biotin(GO:0070781) histone biotinylation(GO:0071110) |
| 0.0 | 0.2 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.0 | 1.1 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.0 | 0.1 | GO:1900086 | regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086) |
| 0.0 | 0.1 | GO:0072092 | ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093) |
| 0.0 | 0.1 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) |
| 0.0 | 0.1 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.0 | 0.0 | GO:0060454 | positive regulation of gastric acid secretion(GO:0060454) |
| 0.0 | 0.0 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.0 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.0 | 0.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.1 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.1 | GO:0098712 | L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712) L-glutamate import across plasma membrane(GO:0098712) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.2 | 0.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.2 | 1.6 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.1 | 1.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 0.3 | GO:0036284 | tubulobulbar complex(GO:0036284) |
| 0.1 | 0.4 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 2.0 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.1 | 0.2 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.1 | 0.4 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.1 | 0.2 | GO:0044753 | amphisome(GO:0044753) |
| 0.1 | 0.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.2 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.2 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.0 | 1.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.5 | GO:0098845 | postsynaptic endosome(GO:0098845) |
| 0.0 | 0.3 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 0.5 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.2 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.3 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.0 | 0.1 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.0 | 0.2 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.0 | 1.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.2 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.1 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.0 | 0.1 | GO:0005713 | recombination nodule(GO:0005713) |
| 0.0 | 0.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.2 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.1 | GO:0030312 | external encapsulating structure(GO:0030312) |
| 0.0 | 0.4 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.2 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 0.0 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.6 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.5 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 0.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.1 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 1.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 1.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 2.1 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.8 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.1 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.1 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.4 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 1.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.3 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.6 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.2 | 3.0 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 0.9 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 1.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 0.9 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 1.0 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.2 | 0.8 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.2 | 1.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 0.5 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.1 | 0.7 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.1 | 0.6 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.1 | 0.6 | GO:0052596 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.1 | 0.4 | GO:0032428 | sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428) |
| 0.1 | 0.4 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.1 | 0.7 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.1 | 0.6 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 0.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 1.4 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.1 | 0.6 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 0.5 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 0.8 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.1 | 1.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.1 | 0.6 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 0.3 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.1 | 0.2 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 0.1 | 2.0 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 0.4 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.1 | 1.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.2 | GO:0004961 | thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961) |
| 0.1 | 0.8 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 0.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.2 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.5 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 0.7 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 0.8 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.1 | 0.2 | GO:0044713 | GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693) |
| 0.1 | 0.2 | GO:1904713 | beta-catenin destruction complex binding(GO:1904713) |
| 0.1 | 0.3 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.1 | 0.2 | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity(GO:0004419) |
| 0.1 | 0.2 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.1 | 0.2 | GO:0047291 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.1 | 0.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.4 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.1 | 0.2 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.0 | 0.6 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.0 | 1.3 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.0 | 0.9 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.0 | 0.5 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 1.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 1.0 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 0.1 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.0 | 0.5 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 0.6 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.0 | 0.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 0.1 | GO:0043682 | copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682) |
| 0.0 | 0.6 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.1 | GO:0036505 | prosaposin receptor activity(GO:0036505) |
| 0.0 | 0.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 1.0 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 0.1 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.0 | 0.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 0.3 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.0 | 0.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.0 | 0.6 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 0.1 | GO:0052794 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.0 | 0.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.5 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 6.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.5 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.3 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.6 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.0 | 0.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 0.1 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 1.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.5 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 0.3 | GO:0030369 | complement component C3b binding(GO:0001851) ICAM-3 receptor activity(GO:0030369) |
| 0.0 | 0.4 | GO:0004673 | protein histidine kinase activity(GO:0004673) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.0 | 0.2 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 0.2 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
| 0.0 | 0.6 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 0.2 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.1 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.0 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.1 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.0 | 0.1 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.0 | 0.3 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 0.2 | GO:0015288 | porin activity(GO:0015288) |
| 0.0 | 0.6 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 4.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.1 | GO:0015141 | succinate transmembrane transporter activity(GO:0015141) |
| 0.0 | 0.2 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 0.0 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.0 | 0.1 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.2 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.0 | 0.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.1 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.0 | 0.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.1 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.0 | 0.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.5 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.1 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 0.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.9 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) |
| 0.0 | 0.2 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.0 | 0.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 0.2 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.0 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.0 | 0.1 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.2 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.3 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.2 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.2 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.7 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 0.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 0.0 | GO:0018271 | biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271) |
| 0.0 | 1.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.0 | 0.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.0 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 0.0 | 0.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.5 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 1.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 1.2 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.4 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 1.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.9 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.9 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.5 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 1.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.0 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.7 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.4 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.2 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.6 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.3 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 1.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.2 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.2 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.3 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.0 | 0.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |