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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ESRRA_ESR2
Z-value: 2.05
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg38_v1_chr11_+_64305497_64305532 | 0.58 | 8.7e-04 | Click! |
| ESR2 | hg38_v1_chr14_-_64338096_64338124 | -0.30 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_4786433 Show fit | 8.48 |
ENST00000354194.4
|
vitelline membrane outer layer 1 homolog |
|
| chr21_+_41316747 Show fit | 7.02 |
ENST00000357985.7
ENST00000398647.7 ENST00000398652.7 |
FAM3 metabolism regulating signaling molecule B |
|
| chr1_+_205579531 Show fit | 7.00 |
ENST00000616173.4
ENST00000536357.2 ENST00000621216.1 |
major facilitator superfamily domain containing 4A |
|
| chr16_+_2830155 Show fit | 6.80 |
ENST00000382280.7
|
zymogen granule protein 16B |
|
| chr20_+_33237712 Show fit | 6.79 |
ENST00000618484.1
|
BPI fold containing family A member 1 |
|
| chr17_-_4786354 Show fit | 6.62 |
ENST00000328739.6
ENST00000441199.2 ENST00000416307.6 |
vitelline membrane outer layer 1 homolog |
|
| chr9_-_127874964 Show fit | 6.12 |
ENST00000373156.5
|
adenylate kinase 1 |
|
| chr20_+_33283205 Show fit | 5.84 |
ENST00000253354.2
|
BPI fold containing family B member 1 |
|
| chr16_+_2830368 Show fit | 5.78 |
ENST00000572863.1
|
zymogen granule protein 16B |
|
| chr19_-_8981342 Show fit | 5.75 |
ENST00000397910.8
|
mucin 16, cell surface associated |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.3 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.2 | 14.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 12.8 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.7 | 12.6 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 11.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 3.6 | 10.9 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 9.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 9.4 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.4 | 8.8 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 1.4 | 8.7 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 20.3 | GO:0005770 | late endosome(GO:0005770) |
| 0.8 | 16.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 15.4 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 14.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 14.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 11.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.6 | 11.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 9.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 8.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.5 | 18.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.2 | 14.5 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.6 | 12.3 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 11.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 10.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 9.7 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 8.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.4 | 8.3 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.1 | 8.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 14.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 9.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 5.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 5.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 4.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 4.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.7 | 14.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 13.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.4 | 11.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 11.6 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.7 | 9.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 9.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.4 | 8.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 7.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 6.6 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |