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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for EZH2
Z-value: 1.25
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Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg38_v1_chr7_-_148884159_148884255 | -0.44 | 1.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.3 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.1 | 4.9 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.2 | 4.1 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.8 | 3.1 | GO:1900190 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.3 | 2.9 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 2.9 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.1 | 2.7 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.6 | 2.4 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.1 | 2.2 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 2.1 | GO:0045727 | positive regulation of translation(GO:0045727) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.4 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 1.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.4 | 1.2 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.3 | 1.2 | GO:0038038 | G-protein coupled receptor homodimeric complex(GO:0038038) |
| 0.2 | 1.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.7 | 5.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 3.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.6 | 3.5 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.0 | 3.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.2 | 3.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 1.0 | 2.9 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 2.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.2 | 2.3 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.3 | GO:0015643 | toxic substance binding(GO:0015643) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 3.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 2.5 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 2.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 3.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 3.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 2.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 2.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |