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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOSL1
Z-value: 2.15
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Transcription factors associated with FOSL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg38_v1_chr11_-_65900413_65900424 | 0.88 | 1.8e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 34.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.0 | 30.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.4 | 24.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 8.0 | 23.9 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.3 | 21.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.6 | 21.2 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 20.2 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 2.9 | 17.4 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.9 | 15.7 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.1 | 14.4 | GO:0070268 | cornification(GO:0070268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 67.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 2.7 | 32.6 | GO:0043256 | laminin complex(GO:0043256) |
| 1.5 | 30.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 30.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 30.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 24.2 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 1.9 | 21.2 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 14.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.7 | 13.4 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.3 | 13.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 29.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 27.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 23.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 21.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 18.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 18.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 16.4 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.2 | 16.2 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.1 | 15.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 13.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 43.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.0 | 38.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.6 | 35.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 35.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 22.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 20.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 12.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 11.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.2 | 9.5 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.9 | 21.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.7 | 17.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.4 | 16.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 12.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 12.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 12.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 11.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 11.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 11.0 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |