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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 1.94
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP2 | hg38_v1_chr7_+_114414809_114414822 | 0.84 | 8.4e-09 | Click! |
| FOXK1 | hg38_v1_chr7_+_4682252_4682314 | -0.75 | 1.7e-06 | Click! |
| FOXP3 | hg38_v1_chrX_-_49264668_49264800 | -0.47 | 8.2e-03 | Click! |
| FOXB1 | hg38_v1_chr15_+_60004305_60004319 | 0.00 | 1.0e+00 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_71157872 Show fit | 32.15 |
ENST00000546561.2
|
tetraspanin 8 |
|
| chr1_-_161367872 Show fit | 27.01 |
ENST00000367974.2
|
cilia and flagella associated protein 126 |
|
| chr12_-_71157992 Show fit | 26.91 |
ENST00000247829.8
|
tetraspanin 8 |
|
| chr13_+_50015438 Show fit | 21.75 |
ENST00000312942.2
|
potassium channel regulator |
|
| chr13_+_50015254 Show fit | 20.08 |
ENST00000360473.8
|
potassium channel regulator |
|
| chr13_-_38990824 Show fit | 18.06 |
ENST00000379631.9
|
stomatin like 3 |
|
| chr4_+_164754045 Show fit | 16.06 |
ENST00000515485.5
|
small integral membrane protein 31 |
|
| chr13_-_38990856 Show fit | 15.31 |
ENST00000423210.1
|
stomatin like 3 |
|
| chr2_+_70935919 Show fit | 14.06 |
ENST00000412314.5
|
ATPase H+ transporting V1 subunit B1 |
|
| chr2_+_70935864 Show fit | 14.02 |
ENST00000234396.10
ENST00000454446.6 |
ATPase H+ transporting V1 subunit B1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 46.8 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 2.4 | 42.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.1 | 31.2 | GO:0044782 | cilium organization(GO:0044782) |
| 3.5 | 28.3 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.7 | 27.4 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 5.4 | 21.7 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 19.2 | GO:0016266 | O-glycan processing(GO:0016266) |
| 6.0 | 17.9 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 5.5 | 16.4 | GO:0021758 | caudate nucleus development(GO:0021757) putamen development(GO:0021758) |
| 0.5 | 15.3 | GO:0060972 | left/right pattern formation(GO:0060972) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 32.7 | GO:0036064 | ciliary basal body(GO:0036064) |
| 2.1 | 27.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.4 | 27.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 23.3 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 22.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 14.9 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 14.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.4 | 14.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.5 | 14.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 3.5 | 13.9 | GO:0044307 | dendritic branch(GO:0044307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.1 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 5.6 | 27.9 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 1.2 | 24.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 19.1 | GO:0005178 | integrin binding(GO:0005178) |
| 1.5 | 17.9 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 16.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 15.9 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.8 | 15.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 15.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.2 | 13.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 16.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 9.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 8.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.3 | 6.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 6.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 6.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 5.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 4.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 25.8 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 23.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.7 | 21.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.7 | 21.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.4 | 15.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 1.4 | 15.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.3 | 13.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.3 | 8.2 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.3 | 7.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.3 | 6.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |