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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for FOXM1_TBL1XR1
Z-value: 1.40
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg38_v1_chr3_-_177197429_177197492, hg38_v1_chr3_-_177196451_177196489 | -0.65 | 9.5e-05 | Click! |
| FOXM1 | hg38_v1_chr12_-_2877113_2877182, hg38_v1_chr12_-_2876986_2877092 | -0.40 | 2.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 39.3 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.7 | 35.0 | GO:0035082 | axoneme assembly(GO:0035082) |
| 1.3 | 30.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.4 | 27.4 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.6 | 11.4 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 11.3 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.4 | 10.6 | GO:0015671 | oxygen transport(GO:0015671) |
| 2.4 | 9.7 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.1 | 9.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.7 | 8.6 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 46.7 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 29.3 | GO:0005929 | cilium(GO:0005929) |
| 1.3 | 25.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.7 | 15.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 14.4 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 13.6 | GO:0005814 | centriole(GO:0005814) |
| 1.7 | 12.0 | GO:0002177 | manchette(GO:0002177) |
| 3.5 | 10.4 | GO:0001534 | radial spoke(GO:0001534) |
| 1.0 | 10.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.4 | 8.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 30.5 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 12.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.8 | 11.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.6 | 11.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.6 | 11.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.4 | 10.8 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.3 | 9.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 1.5 | 9.2 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 1.4 | 8.6 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.2 | 7.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 10.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.8 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 3.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 2.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 2.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 27.6 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.7 | 14.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.6 | 14.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.1 | 13.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 12.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.9 | 10.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 9.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.8 | 8.9 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 8.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 7.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |