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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GATA3
Z-value: 1.63
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg38_v1_chr10_+_8054668_8054697 | 0.28 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_55833186 Show fit | 4.31 |
ENST00000361503.8
ENST00000422046.6 |
carboxylesterase 1 |
|
| chr12_-_52385649 Show fit | 2.66 |
ENST00000257951.3
|
keratin 84 |
|
| chr19_+_14941489 Show fit | 2.57 |
ENST00000248072.3
|
olfactory receptor family 7 subfamily C member 2 |
|
| chr19_-_50983815 Show fit | 2.44 |
ENST00000391807.5
ENST00000593904.1 ENST00000595820.6 |
kallikrein related peptidase 7 |
|
| chr5_-_39274515 Show fit | 2.20 |
ENST00000510188.1
|
FYN binding protein 1 |
|
| chr11_+_111255982 Show fit | 2.19 |
ENST00000637637.1
|
chromosome 11 open reading frame 53 |
|
| chr1_+_152514474 Show fit | 2.08 |
ENST00000368790.4
|
cysteine rich C-terminal 1 |
|
| chr19_-_50953063 Show fit | 1.97 |
ENST00000391809.6
|
kallikrein related peptidase 5 |
|
| chr22_-_37484505 Show fit | 1.83 |
ENST00000442496.1
|
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
|
| chr1_+_150508099 Show fit | 1.81 |
ENST00000346569.6
ENST00000369047.9 |
extracellular matrix protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 11.1 | GO:0070268 | cornification(GO:0070268) |
| 1.6 | 9.5 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.0 | 8.4 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.1 | 7.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 5.4 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 5.3 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.4 | 5.1 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.1 | 5.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.2 | 4.6 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 12.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.4 | 10.0 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 9.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 7.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 6.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 6.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 6.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 5.9 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
| 0.2 | 5.3 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 11.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 8.5 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.0 | 7.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 6.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 6.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 5.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 5.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 4.9 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 11.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 7.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 6.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 5.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 4.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 8.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 7.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 6.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 5.3 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.2 | 4.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.2 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 4.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 3.9 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 3.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |