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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for GATA6

Z-value: 0.41

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.11 GATA6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg38_v1_chr18_+_22169580_221695960.579.4e-04Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_102311502 3.15 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr7_+_142760398 1.62 ENST00000632998.1
PRSS2
serine protease 2
chr9_+_33795551 1.36 ENST00000379405.4
PRSS3
serine protease 3
chr17_+_76385256 1.17 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr20_-_56392131 1.00 ENST00000422322.5
ENST00000371356.6
ENST00000451915.1
ENST00000347343.6
ENST00000395911.5
ENST00000395915.8
ENST00000395907.5
ENST00000441357.5
ENST00000456249.5
ENST00000420474.5
ENST00000395914.5
ENST00000312783.10
ENST00000395913.7
AURKA
aurora kinase A
chr7_+_155298561 0.86 ENST00000476756.1
INSIG1
insulin induced gene 1
chr6_+_12290353 0.76 ENST00000379375.6
EDN1
endothelin 1
chr7_+_142749465 0.74 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
PRSS1
serine protease 1
chr4_-_102345196 0.74 ENST00000683412.1
ENST00000682227.1
SLC39A8
solute carrier family 39 member 8
chr1_-_24143112 0.73 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chrX_+_38006551 0.73 ENST00000297875.7
SYTL5
synaptotagmin like 5
chr8_+_123182635 0.67 ENST00000276699.10
ENST00000522648.5
FAM83A
family with sequence similarity 83 member A
chr1_-_93585071 0.65 ENST00000539242.5
BCAR3
BCAR3 adaptor protein, NSP family member
chr12_+_4321197 0.62 ENST00000179259.6
TIGAR
TP53 induced glycolysis regulatory phosphatase
chr2_-_68871382 0.56 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr9_-_112175264 0.55 ENST00000374264.6
SUSD1
sushi domain containing 1
chr9_-_112175185 0.51 ENST00000355396.7
SUSD1
sushi domain containing 1
chr18_+_22169580 0.49 ENST00000269216.10
GATA6
GATA binding protein 6
chr5_+_132073782 0.46 ENST00000296871.4
CSF2
colony stimulating factor 2
chrX_+_108044967 0.41 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr19_+_10286971 0.40 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chrX_+_108045050 0.40 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr19_+_10286944 0.39 ENST00000380770.5
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr2_-_43838832 0.38 ENST00000405322.8
ABCG5
ATP binding cassette subfamily G member 5
chr9_-_112175283 0.37 ENST00000374270.8
ENST00000374263.7
SUSD1
sushi domain containing 1
chr10_-_127892930 0.37 ENST00000368671.4
CLRN3
clarin 3
chr1_-_158686700 0.33 ENST00000643759.2
SPTA1
spectrin alpha, erythrocytic 1
chr8_+_69492793 0.33 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr11_-_66438788 0.32 ENST00000329819.4
ENST00000310999.11
ENST00000430466.6
MRPL11
mitochondrial ribosomal protein L11
chr1_-_225999312 0.31 ENST00000272091.8
SDE2
SDE2 telomere maintenance homolog
chr17_+_19411220 0.31 ENST00000461366.2
RNF112
ring finger protein 112
chr13_-_46142834 0.30 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr4_-_102345061 0.28 ENST00000394833.6
SLC39A8
solute carrier family 39 member 8
chr19_-_38812936 0.26 ENST00000307751.9
ENST00000594209.1
LGALS4
galectin 4
chr17_+_77287891 0.25 ENST00000449803.6
ENST00000431235.6
SEPTIN9
septin 9
chr6_+_130018565 0.22 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr21_-_38498415 0.22 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr1_-_167518521 0.22 ENST00000362089.10
CD247
CD247 molecule
chr1_-_167518583 0.21 ENST00000392122.3
CD247
CD247 molecule
chr8_-_94436926 0.21 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr2_+_102311546 0.21 ENST00000233954.6
ENST00000447231.5
IL1RL1
interleukin 1 receptor like 1
chr8_+_21966215 0.21 ENST00000433566.8
XPO7
exportin 7
chr7_-_142962206 0.20 ENST00000460479.2
ENST00000476829.5
ENST00000355265.7
KEL
Kell metallo-endopeptidase (Kell blood group)
chr11_+_10305065 0.20 ENST00000534464.1
ENST00000278175.10
ENST00000530439.1
ENST00000524948.5
ENST00000528655.5
ENST00000526492.4
ENST00000525063.2
ADM
adrenomedullin
chr18_-_31162849 0.17 ENST00000257197.7
ENST00000257198.6
DSC1
desmocollin 1
chr10_+_69315760 0.15 ENST00000298649.8
HK1
hexokinase 1
chr8_-_41797589 0.14 ENST00000347528.8
ENST00000289734.13
ANK1
ankyrin 1
chr6_-_30160880 0.14 ENST00000376704.3
TRIM10
tripartite motif containing 10
chr10_+_116590956 0.13 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr1_-_206023889 0.13 ENST00000358184.7
ENST00000360218.3
ENST00000678712.1
ENST00000678498.1
CTSE
cathepsin E
chr1_+_66534171 0.12 ENST00000682762.1
ENST00000424320.6
SGIP1
SH3GL interacting endocytic adaptor 1
chr1_-_42164737 0.12 ENST00000357001.3
GUCA2A
guanylate cyclase activator 2A
chr10_+_116591010 0.12 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr6_+_31706866 0.11 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr22_-_29388530 0.11 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
AP1B1
adaptor related protein complex 1 subunit beta 1
chr19_-_13102848 0.10 ENST00000264824.5
LYL1
LYL1 basic helix-loop-helix family member
chr19_+_14028148 0.10 ENST00000431365.3
ENST00000585987.1
RLN3
relaxin 3
chr2_+_219572304 0.10 ENST00000243786.3
INHA
inhibin subunit alpha
chr4_+_15374541 0.09 ENST00000382383.7
ENST00000429690.5
C1QTNF7
C1q and TNF related 7
chr6_-_30161200 0.09 ENST00000449742.7
TRIM10
tripartite motif containing 10
chr19_-_51019699 0.09 ENST00000358789.8
KLK10
kallikrein related peptidase 10
chr11_-_57390636 0.09 ENST00000525955.1
ENST00000533605.5
ENST00000311862.10
PRG2
proteoglycan 2, pro eosinophil major basic protein
chr17_+_4932285 0.09 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr17_-_40782544 0.08 ENST00000301656.4
KRT27
keratin 27
chr9_-_114930508 0.08 ENST00000223795.3
ENST00000618336.4
TNFSF8
TNF superfamily member 8
chr5_+_1201588 0.08 ENST00000304460.11
SLC6A19
solute carrier family 6 member 19
chr8_+_69466617 0.08 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
SULF1
sulfatase 1
chr5_-_135954962 0.08 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr1_+_25272527 0.08 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
RHD
Rh blood group D antigen
chr7_-_100641507 0.08 ENST00000431692.5
ENST00000223051.8
TFR2
transferrin receptor 2
chr5_-_33984636 0.07 ENST00000382102.7
ENST00000509381.1
SLC45A2
solute carrier family 45 member 2
chr12_+_69825221 0.07 ENST00000552032.7
MYRFL
myelin regulatory factor like
chr19_+_35358460 0.07 ENST00000327809.5
FFAR3
free fatty acid receptor 3
chr1_+_25272492 0.06 ENST00000454452.6
RHD
Rh blood group D antigen
chr18_+_45724127 0.06 ENST00000619403.4
ENST00000587601.5
SLC14A1
solute carrier family 14 member 1 (Kidd blood group)
chr1_+_50108856 0.06 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr12_-_55827546 0.06 ENST00000546837.5
ENSG00000257390.5
novel protein
chr19_+_35358821 0.06 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr17_+_4932248 0.06 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr4_+_99574812 0.06 ENST00000422897.6
ENST00000265517.10
MTTP
microsomal triglyceride transfer protein
chr19_-_11384299 0.06 ENST00000592375.6
ENST00000222139.11
EPOR
erythropoietin receptor
chr20_+_44401269 0.05 ENST00000443598.6
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4 alpha
chr4_-_119322128 0.05 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr8_-_144792380 0.05 ENST00000532702.1
ENST00000394920.6
ENST00000528957.6
ENST00000527914.5
RPL8
ribosomal protein L8
chr11_-_59845496 0.05 ENST00000257248.3
CBLIF
cobalamin binding intrinsic factor
chr12_+_69825273 0.05 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr17_-_64006880 0.05 ENST00000449662.6
ICAM2
intercellular adhesion molecule 2
chr20_-_32207708 0.05 ENST00000246229.5
PLAGL2
PLAG1 like zinc finger 2
chr3_+_152268920 0.05 ENST00000495875.6
ENST00000324210.10
ENST00000493459.5
MBNL1
muscleblind like splicing regulator 1
chr7_+_128739292 0.05 ENST00000535011.6
ENST00000542996.6
ENST00000249364.9
ENST00000449187.6
CALU
calumenin
chr20_+_45306834 0.05 ENST00000343694.8
ENST00000372741.7
ENST00000372743.5
RBPJL
recombination signal binding protein for immunoglobulin kappa J region like
chr3_+_148865288 0.05 ENST00000296046.4
CPA3
carboxypeptidase A3
chr6_-_46080332 0.04 ENST00000185206.12
CLIC5
chloride intracellular channel 5
chr7_+_128739395 0.04 ENST00000479257.5
CALU
calumenin
chr5_+_136160986 0.04 ENST00000507637.1
SMAD5
SMAD family member 5
chr2_+_172928165 0.04 ENST00000535187.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr18_+_45724172 0.04 ENST00000321925.9
ENST00000415427.7
ENST00000589322.7
ENST00000586951.6
ENST00000535474.5
ENST00000402943.6
SLC14A1
solute carrier family 14 member 1 (Kidd blood group)
chr11_+_119087979 0.04 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
HMBS
hydroxymethylbilane synthase
chr20_+_56392607 0.04 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr5_-_33984681 0.04 ENST00000296589.9
SLC45A2
solute carrier family 45 member 2
chr14_+_21477177 0.03 ENST00000448790.7
ENST00000673643.1
ENST00000457430.2
ENST00000673911.1
TOX4
TOX high mobility group box family member 4
chr1_+_154321107 0.03 ENST00000484864.1
AQP10
aquaporin 10
chr1_+_25272479 0.02 ENST00000622561.4
RHD
Rh blood group D antigen
chr17_+_58755821 0.02 ENST00000308249.4
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
chr18_+_3447562 0.02 ENST00000618001.4
TGIF1
TGFB induced factor homeobox 1
chr15_+_49423233 0.02 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr15_+_58987652 0.02 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr1_+_12464912 0.02 ENST00000543766.2
VPS13D
vacuolar protein sorting 13 homolog D
chr12_+_71938837 0.01 ENST00000333850.4
TPH2
tryptophan hydroxylase 2
chr13_-_27969295 0.01 ENST00000381020.8
CDX2
caudal type homeobox 2
chr16_+_31527876 0.01 ENST00000302312.9
ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr1_+_25272502 0.01 ENST00000328664.9
RHD
Rh blood group D antigen
chr4_+_165873231 0.01 ENST00000061240.7
TLL1
tolloid like 1
chr12_-_6124662 0.01 ENST00000261405.10
VWF
von Willebrand factor
chr19_-_55038256 0.01 ENST00000417454.5
ENST00000310373.7
ENST00000333884.2
GP6
glycoprotein VI platelet
chr11_-_26722051 0.01 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr9_-_97938157 0.01 ENST00000616898.2
HEMGN
hemogen
chr1_+_154321076 0.00 ENST00000324978.8
AQP10
aquaporin 10
chr11_+_75717811 0.00 ENST00000198801.10
MOGAT2
monoacylglycerol O-acyltransferase 2
chr12_-_21775581 0.00 ENST00000537950.1
ENST00000665145.1
KCNJ8
potassium inwardly rectifying channel subfamily J member 8

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.4 1.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 1.0 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.3 0.9 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.3 0.8 GO:0030185 nitric oxide transport(GO:0030185)
0.2 0.6 GO:1902688 fermentation(GO:0006113) regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688)
0.2 0.5 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.0 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.6 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 2.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.2 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.1 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.0 0.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.2 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.1 GO:0002215 defense response to nematode(GO:0002215)
0.0 0.1 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.6 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.1 GO:0097460 ferrous iron import(GO:0070627) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 0.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.2 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.6 GO:0035578 azurophil granule lumen(GO:0035578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.6 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.2 1.2 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.8 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 1.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.7 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.6 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0015265 urea channel activity(GO:0015265)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.2 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.0 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.0 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 3.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.0 PID AURORA A PATHWAY Aurora A signaling
0.0 4.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse