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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GFI1
Z-value: 0.85
Motif logo
Transcription factors associated with GFI1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GFI1
|
ENSG00000162676.12 | GFI1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GFI1 | hg38_v1_chr1_-_92483947_92483960, hg38_v1_chr1_-_92486049_92486104, hg38_v1_chr1_-_92486916_92486932 | 0.29 | 1.2e-01 | Click! |
Activity profile of GFI1 motif
Sorted Z-values of GFI1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GFI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.0 | GO:0061713 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 1.1 | 3.4 | GO:0021757 | caudate nucleus development(GO:0021757) putamen development(GO:0021758) |
| 1.1 | 3.2 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 0.5 | 3.1 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 0.5 | 3.7 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 0.4 | 1.3 | GO:1903565 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.4 | 1.3 | GO:0061445 | endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445) |
| 0.3 | 1.0 | GO:0061026 | cardiac muscle tissue regeneration(GO:0061026) |
| 0.3 | 5.9 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.3 | 0.9 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) |
| 0.3 | 1.2 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.3 | 1.4 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.3 | 1.6 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.2 | 4.3 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.2 | 0.6 | GO:0034395 | regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) |
| 0.2 | 0.6 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.2 | 1.3 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.2 | 0.5 | GO:0070843 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.2 | 1.0 | GO:0043366 | beta selection(GO:0043366) |
| 0.2 | 1.6 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.1 | 1.3 | GO:0046100 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 0.1 | 0.5 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.1 | 0.5 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.1 | 2.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.9 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.1 | 1.1 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052) |
| 0.1 | 0.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 1.3 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.1 | 0.5 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.1 | 0.3 | GO:1902869 | commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) regulation of amacrine cell differentiation(GO:1902869) |
| 0.1 | 0.5 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.1 | 0.7 | GO:0048619 | embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 1.7 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 2.6 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.1 | 1.2 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 1.7 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 0.3 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.1 | 2.1 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 0.7 | GO:0072423 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
| 0.1 | 0.5 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.1 | 0.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.1 | 0.4 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.1 | 0.4 | GO:0021779 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 0.2 | GO:0071676 | negative regulation of mononuclear cell migration(GO:0071676) |
| 0.1 | 0.3 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.1 | 0.4 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.1 | 0.7 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 0.1 | 0.2 | GO:0035922 | pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905) |
| 0.1 | 0.2 | GO:0071879 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) |
| 0.1 | 0.4 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.1 | 0.3 | GO:2000053 | regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 0.1 | 0.2 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903) |
| 0.1 | 2.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.4 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 0.5 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 1.6 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.1 | 3.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 0.3 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
| 0.0 | 0.3 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.0 | 2.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.5 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 0.5 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 0.4 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.4 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.0 | 0.5 | GO:0097267 | omega-hydroxylase P450 pathway(GO:0097267) |
| 0.0 | 0.4 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.0 | 0.4 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.0 | 0.2 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.0 | 0.2 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.0 | 0.4 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.0 | 0.4 | GO:0019064 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 1.1 | GO:0002717 | positive regulation of natural killer cell mediated immunity(GO:0002717) |
| 0.0 | 0.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.2 | GO:0006127 | glycerophosphate shuttle(GO:0006127) |
| 0.0 | 0.8 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.4 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.0 | 0.4 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.0 | 0.6 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.8 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.1 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.0 | 0.3 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.0 | 2.8 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 1.3 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.0 | 0.1 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 0.5 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.2 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.0 | 0.4 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.1 | GO:0039516 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.0 | 0.4 | GO:2000400 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.0 | 0.2 | GO:0061743 | motor learning(GO:0061743) |
| 0.0 | 0.2 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.0 | 1.2 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.6 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.0 | 0.2 | GO:0033088 | regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.0 | 4.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.7 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.0 | 0.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.0 | 0.2 | GO:0086043 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.0 | 2.3 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.0 | 0.7 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 0.3 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.1 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.1 | GO:0003174 | mitral valve development(GO:0003174) |
| 0.0 | 0.3 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 1.0 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 1.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.2 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.0 | 0.2 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.0 | 0.3 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.6 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.9 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.0 | 0.1 | GO:0021793 | chemorepulsion of branchiomotor axon(GO:0021793) |
| 0.0 | 0.7 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 0.1 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
| 0.0 | 0.1 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.0 | 0.6 | GO:2000059 | negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059) |
| 0.0 | 0.2 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.0 | 0.2 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.0 | 0.4 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 1.4 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 0.0 | 0.2 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 0.6 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 2.0 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 0.0 | 2.8 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.0 | 0.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.0 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of antigen processing and presentation of peptide antigen(GO:0002584) |
| 0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.0 | 0.2 | GO:0021960 | anterior commissure morphogenesis(GO:0021960) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 0.2 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.2 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.0 | 0.1 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 0.4 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.0 | 0.9 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 0.2 | GO:0032026 | response to magnesium ion(GO:0032026) |
| 0.0 | 0.2 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 0.2 | GO:0048311 | mitochondrion distribution(GO:0048311) |
| 0.0 | 0.2 | GO:0002693 | positive regulation of cellular extravasation(GO:0002693) |
| 0.0 | 0.1 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
| 0.0 | 0.3 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 0.5 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.0 | 0.2 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.0 | 0.0 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.6 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.4 | 4.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.3 | 2.6 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.3 | 2.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.3 | 1.3 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.2 | 0.7 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.2 | 5.0 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 3.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.3 | GO:0002169 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202) |
| 0.2 | 0.6 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.1 | 0.9 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 0.8 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.1 | 2.8 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 2.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.4 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.1 | 1.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 0.3 | GO:0070701 | mucus layer(GO:0070701) |
| 0.1 | 2.7 | GO:0038201 | TOR complex(GO:0038201) |
| 0.1 | 0.7 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.1 | 2.9 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.2 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 0.4 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 0.1 | GO:0032127 | dense core granule membrane(GO:0032127) |
| 0.0 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.9 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 1.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.3 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 0.4 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 3.7 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.2 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 1.1 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 5.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.4 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 0.7 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.3 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 1.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 3.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 2.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.1 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.9 | GO:0031514 | motile cilium(GO:0031514) |
| 0.0 | 0.1 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 1.0 | GO:0035580 | specific granule lumen(GO:0035580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 1.2 | 5.0 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.7 | 5.9 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.6 | 3.0 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.5 | 1.5 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.4 | 1.4 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.3 | 0.9 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
| 0.3 | 2.3 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.3 | 1.6 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.2 | 2.7 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.2 | 3.7 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.2 | 4.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 0.7 | GO:0001156 | TFIIIC-class transcription factor binding(GO:0001156) |
| 0.2 | 1.3 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.2 | 3.1 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.2 | 0.5 | GO:0016497 | substance K receptor activity(GO:0016497) |
| 0.1 | 0.9 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 0.6 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 1.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 0.7 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 3.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 0.6 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.1 | 2.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.5 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 0.3 | GO:0032090 | Pyrin domain binding(GO:0032090) |
| 0.1 | 0.6 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.1 | 0.5 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.1 | 3.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 0.6 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.1 | 0.4 | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.1 | 2.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.5 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 1.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 0.7 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.1 | 0.4 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 0.9 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.7 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 0.2 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 0.2 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.1 | 1.4 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.1 | 0.2 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.1 | 0.4 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.3 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 0.2 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.1 | 0.8 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 0.2 | GO:0072590 | N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) |
| 0.1 | 0.2 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.1 | 0.7 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.0 | 3.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.2 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.0 | 0.4 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.0 | 3.5 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.0 | 0.1 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 0.0 | 0.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 1.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.2 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711) metallodipeptidase activity(GO:0070573) |
| 0.0 | 0.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.9 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 1.0 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.1 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.1 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.0 | 1.2 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 2.1 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.2 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.7 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.7 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.5 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.3 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.1 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.0 | 0.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.5 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.6 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.2 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.0 | 0.1 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 1.2 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0035197 | siRNA binding(GO:0035197) |
| 0.0 | 0.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.4 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 0.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.6 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 0.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.2 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 0.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.2 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 1.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 2.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 3.0 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.1 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 2.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.6 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.4 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.3 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 2.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 3.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 0.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 3.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 1.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 1.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 2.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.7 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.2 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.0 | 0.4 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 2.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.2 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |