Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GGCAGUG
Z-value: 0.79
Motif logo
miRNA associated with seed GGCAGUG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-34a-5p
|
MIMAT0000255 |
|
hsa-miR-34c-5p
|
MIMAT0000686 |
|
hsa-miR-449a
|
MIMAT0001541 |
|
hsa-miR-449b-5p
|
MIMAT0003327 |
Activity profile of GGCAGUG motif
Sorted Z-values of GGCAGUG motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GGCAGUG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.8 | 2.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.3 | 0.9 | GO:0001579 | medium-chain fatty acid transport(GO:0001579) |
| 0.3 | 1.0 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.2 | 0.7 | GO:0097534 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.2 | 1.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.2 | 1.7 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669) |
| 0.2 | 0.8 | GO:0006169 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) |
| 0.2 | 1.8 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.2 | 0.6 | GO:0071962 | mitotic sister chromatid cohesion, centromeric(GO:0071962) |
| 0.2 | 0.9 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.2 | 0.7 | GO:0061443 | ciliary body morphogenesis(GO:0061073) endocardial cushion cell differentiation(GO:0061443) |
| 0.2 | 0.7 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.2 | 0.6 | GO:0042631 | cellular response to water deprivation(GO:0042631) |
| 0.2 | 1.4 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.2 | 0.6 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.2 | 1.3 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 0.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.1 | 0.7 | GO:0032485 | Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485) |
| 0.1 | 1.0 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.1 | 0.8 | GO:0090170 | regulation of Golgi inheritance(GO:0090170) |
| 0.1 | 0.7 | GO:1900756 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
| 0.1 | 0.3 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
| 0.1 | 0.7 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 0.1 | 0.3 | GO:0071206 | establishment of protein localization to juxtaparanode region of axon(GO:0071206) |
| 0.1 | 0.5 | GO:0006668 | sphinganine-1-phosphate metabolic process(GO:0006668) |
| 0.1 | 0.6 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
| 0.1 | 0.4 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) |
| 0.1 | 0.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.8 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.1 | 0.8 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 0.9 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.1 | 1.0 | GO:1902414 | protein localization to cell junction(GO:1902414) |
| 0.1 | 1.3 | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471) positive regulation of mitochondrial calcium ion concentration(GO:0051561) |
| 0.1 | 0.2 | GO:0031077 | post-embryonic camera-type eye development(GO:0031077) |
| 0.1 | 0.3 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 0.1 | 0.4 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.1 | 0.5 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.1 | 0.2 | GO:0014016 | proximal/distal axis specification(GO:0009946) neuroblast differentiation(GO:0014016) lens fiber cell apoptotic process(GO:1990086) |
| 0.1 | 0.7 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.1 | GO:0038086 | VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) |
| 0.1 | 0.6 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.1 | 0.3 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 0.1 | 0.2 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724) |
| 0.1 | 0.2 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.1 | 0.3 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.1 | 0.7 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.3 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
| 0.1 | 0.5 | GO:0007028 | cytoplasm organization(GO:0007028) |
| 0.1 | 0.8 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.1 | 0.2 | GO:1900368 | pre-miRNA export from nucleus(GO:0035281) regulation of RNA interference(GO:1900368) |
| 0.1 | 0.3 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 0.4 | GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis(GO:0060979) |
| 0.1 | 0.2 | GO:0042668 | auditory receptor cell fate determination(GO:0042668) |
| 0.1 | 0.5 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 0.3 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.1 | 0.2 | GO:0032848 | negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671) |
| 0.1 | 0.6 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.1 | 0.2 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 0.2 | GO:1900248 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.0 | 0.1 | GO:2000979 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) regulation of forebrain neuron differentiation(GO:2000977) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.0 | 0.4 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.0 | 0.5 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.0 | 0.2 | GO:0060940 | cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.0 | 0.3 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.0 | 0.6 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.0 | 0.3 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 0.5 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 0.8 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.0 | 0.2 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.0 | 0.2 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.0 | 0.1 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 0.0 | 2.0 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.7 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 0.2 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.0 | 0.2 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.2 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.0 | 0.2 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.0 | 0.9 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.0 | 0.4 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.0 | 0.4 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.0 | 0.5 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.3 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.0 | 0.1 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.0 | 0.4 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.0 | 0.2 | GO:0000430 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086) positive regulation of transcription by glucose(GO:0046016) |
| 0.0 | 0.1 | GO:1903336 | negative regulation of vacuolar transport(GO:1903336) |
| 0.0 | 0.7 | GO:0009642 | response to light intensity(GO:0009642) retinal metabolic process(GO:0042574) |
| 0.0 | 0.1 | GO:1903762 | positive regulation of actin filament-based movement(GO:1903116) positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033) |
| 0.0 | 0.4 | GO:0060613 | fat pad development(GO:0060613) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 0.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.2 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
| 0.0 | 0.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.1 | GO:0061196 | fungiform papilla development(GO:0061196) fungiform papilla morphogenesis(GO:0061197) fungiform papilla formation(GO:0061198) |
| 0.0 | 0.5 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.0 | 0.0 | GO:0035799 | ureter maturation(GO:0035799) |
| 0.0 | 0.9 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 0.3 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.0 | 0.1 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167) |
| 0.0 | 0.3 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.0 | 0.3 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.0 | 0.3 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.0 | 0.3 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.0 | 0.3 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.0 | 0.2 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.0 | 0.1 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.0 | 0.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.0 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.0 | 0.3 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.1 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.0 | 0.8 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.0 | 0.1 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) |
| 0.0 | 0.1 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.0 | 0.4 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 0.0 | 0.3 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 0.3 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 0.4 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 0.2 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.0 | 0.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 0.1 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 0.3 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 0.3 | GO:0098779 | mitophagy in response to mitochondrial depolarization(GO:0098779) |
| 0.0 | 0.2 | GO:0044557 | relaxation of smooth muscle(GO:0044557) |
| 0.0 | 0.6 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.0 | 0.2 | GO:0010225 | response to UV-C(GO:0010225) negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.1 | GO:0072718 | response to cisplatin(GO:0072718) |
| 0.0 | 0.2 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.0 | 0.5 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.0 | 0.1 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.0 | 1.3 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 0.4 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.0 | 0.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.4 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.6 | GO:0043278 | response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278) |
| 0.0 | 0.0 | GO:0035905 | ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
| 0.0 | 0.3 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 0.1 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 0.0 | 0.2 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 0.0 | GO:2001153 | negative regulation of glycogen (starch) synthase activity(GO:2000466) regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.0 | 0.0 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.0 | 0.2 | GO:0060081 | membrane hyperpolarization(GO:0060081) |
| 0.0 | 0.5 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.2 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 0.3 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 0.0 | 0.1 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.0 | 0.2 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 1.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.1 | GO:0090500 | endocardial cushion to mesenchymal transition(GO:0090500) |
| 0.0 | 0.2 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.0 | 0.7 | GO:0034383 | low-density lipoprotein particle clearance(GO:0034383) |
| 0.0 | 0.9 | GO:0015914 | phospholipid transport(GO:0015914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.2 | 0.7 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.1 | 0.9 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.7 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 1.0 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 0.8 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.1 | 0.3 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 1.7 | GO:0033643 | host cell part(GO:0033643) |
| 0.1 | 0.2 | GO:1990597 | AIP1-IRE1 complex(GO:1990597) |
| 0.1 | 0.6 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.2 | GO:0042565 | RNA nuclear export complex(GO:0042565) |
| 0.1 | 1.1 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 0.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.1 | 0.6 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 1.0 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.1 | 0.2 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.5 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.2 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.2 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.3 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 4.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.5 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.1 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 1.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.7 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.1 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 1.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.1 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.7 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.2 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.1 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.0 | 1.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.1 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 0.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.1 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.0 | 0.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0000815 | ESCRT III complex(GO:0000815) Flemming body(GO:0090543) |
| 0.0 | 0.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 1.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.4 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.2 | 0.8 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.2 | 0.8 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.2 | 0.6 | GO:0052858 | peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) |
| 0.2 | 1.3 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.2 | 0.6 | GO:0033823 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 0.1 | 2.4 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 0.7 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.1 | 0.5 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.1 | 0.5 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.1 | 0.4 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 0.1 | 0.6 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.1 | 0.7 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.1 | 0.3 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 0.9 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 0.4 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.1 | 0.5 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.1 | 1.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 0.4 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.1 | 0.3 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.1 | 0.2 | GO:0052810 | 1-phosphatidylinositol-5-kinase activity(GO:0052810) |
| 0.1 | 1.0 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.3 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.1 | 0.3 | GO:0008478 | pyridoxal kinase activity(GO:0008478) |
| 0.1 | 0.2 | GO:0090631 | pre-miRNA transporter activity(GO:0090631) |
| 0.1 | 0.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.1 | 0.2 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
| 0.1 | 0.8 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 0.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.4 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 0.9 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 0.2 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 1.3 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.0 | 0.1 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.0 | 0.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 0.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.0 | 0.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.5 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.0 | 0.3 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 0.2 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 1.5 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.0 | 0.2 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.0 | 0.3 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.2 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.0 | 0.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.2 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 0.7 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 1.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.7 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 4.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0070905 | serine binding(GO:0070905) |
| 0.0 | 0.1 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.0 | 0.3 | GO:0046975 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 0.1 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 0.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.4 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.7 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.2 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.0 | 0.1 | GO:0004945 | angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945) |
| 0.0 | 1.1 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.4 | GO:0051430 | corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.1 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.0 | 0.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.2 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 1.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.2 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.0 | 0.1 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.1 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.2 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 0.1 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.0 | 0.1 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 0.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.4 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 0.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.0 | 0.3 | GO:0004697 | protein kinase C activity(GO:0004697) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 3.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.3 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.2 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 1.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 4.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 0.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.5 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.0 | 0.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.8 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.3 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 1.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.5 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.7 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.2 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |