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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for GLIS3

Z-value: 0.35

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.24 GLIS3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS3hg38_v1_chr9_-_4300049_4300120,
hg38_v1_chr9_-_4299547_4299597		0.495.8e-03Click!

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_107044689 1.07 ENST00000265717.5
PRKAR2B
protein kinase cAMP-dependent type II regulatory subunit beta
chr5_+_172959511 0.65 ENST00000519522.1
RPL26L1
ribosomal protein L26 like 1
chr6_+_24494939 0.51 ENST00000348925.2
ENST00000357578.8
ALDH5A1
aldehyde dehydrogenase 5 family member A1
chr6_+_89081787 0.43 ENST00000354922.3
PNRC1
proline rich nuclear receptor coactivator 1
chr15_+_83447411 0.36 ENST00000324537.5
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr1_-_157138474 0.32 ENST00000326786.4
ETV3
ETS variant transcription factor 3
chr1_-_19799872 0.32 ENST00000294543.11
TMCO4
transmembrane and coiled-coil domains 4
chr17_-_79952007 0.26 ENST00000574241.6
TBC1D16
TBC1 domain family member 16
chr17_-_5111836 0.25 ENST00000575898.5
ZNF232
zinc finger protein 232
chr6_-_44265541 0.24 ENST00000619360.6
NFKBIE
NFKB inhibitor epsilon
chr8_-_29263063 0.23 ENST00000524189.6
KIF13B
kinesin family member 13B
chr16_+_84145256 0.21 ENST00000378553.10
DNAAF1
dynein axonemal assembly factor 1
chr21_-_44910630 0.21 ENST00000320216.10
ENST00000397852.5
ITGB2
integrin subunit beta 2
chr20_+_21126037 0.21 ENST00000611685.4
ENST00000616848.4
KIZ
kizuna centrosomal protein
chr8_+_11769639 0.21 ENST00000436750.7
NEIL2
nei like DNA glycosylase 2
chr20_+_21125999 0.21 ENST00000620891.4
KIZ
kizuna centrosomal protein
chr20_+_21125981 0.20 ENST00000619574.4
KIZ
kizuna centrosomal protein
chr22_+_22644475 0.20 ENST00000618722.4
ENST00000652219.1
ENST00000480559.6
ENST00000448514.2
ENST00000652249.1
ENST00000651213.1
GGTLC2
gamma-glutamyltransferase light chain 2
chr18_-_48950960 0.20 ENST00000262158.8
SMAD7
SMAD family member 7
chr20_+_21126074 0.20 ENST00000619189.5
KIZ
kizuna centrosomal protein
chr11_+_818906 0.18 ENST00000336615.9
PNPLA2
patatin like phospholipase domain containing 2
chr8_+_11769696 0.18 ENST00000455213.6
ENST00000403422.7
ENST00000528323.5
ENST00000284503.7
NEIL2
nei like DNA glycosylase 2
chr3_+_173398438 0.16 ENST00000457714.5
NLGN1
neuroligin 1
chr16_-_3235143 0.15 ENST00000414144.7
ENST00000431561.7
ENST00000396870.8
ZNF200
zinc finger protein 200
chr1_-_53945584 0.15 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr12_+_1820255 0.15 ENST00000543818.5
LRTM2
leucine rich repeats and transmembrane domains 2
chr19_-_49325181 0.15 ENST00000454748.7
ENST00000335875.9
ENST00000598828.1
SLC6A16
solute carrier family 6 member 16
chr1_-_53945567 0.14 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr1_+_107056656 0.13 ENST00000370078.2
PRMT6
protein arginine methyltransferase 6
chr19_+_43984167 0.13 ENST00000611002.4
ENST00000270014.7
ENST00000591532.5
ENST00000407951.6
ENST00000590615.5
ENST00000586454.1
ZNF155
zinc finger protein 155
chr6_+_44223553 0.12 ENST00000371740.10
ENST00000371755.9
ENST00000643869.1
ENST00000371731.6
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr15_-_43590155 0.12 ENST00000453080.5
ENST00000360135.8
ENST00000360301.8
ENST00000417085.2
ENST00000431962.1
ENST00000334933.8
ENST00000381879.8
ENST00000420765.5
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr17_+_50835578 0.12 ENST00000311378.5
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr8_-_73878816 0.11 ENST00000602593.6
ENST00000651945.1
ENST00000419880.7
ENST00000517608.5
ENST00000650817.1
UBE2W
ubiquitin conjugating enzyme E2 W
chr9_-_113299196 0.11 ENST00000441031.3
RNF183
ring finger protein 183
chr19_-_55580829 0.10 ENST00000592239.1
ENST00000325421.7
ZNF579
zinc finger protein 579
chr17_+_7888783 0.10 ENST00000330494.12
ENST00000358181.8
CHD3
chromodomain helicase DNA binding protein 3
chr17_+_76000906 0.10 ENST00000448471.2
CDK3
cyclin dependent kinase 3
chr19_+_40775154 0.10 ENST00000594436.5
ENST00000597784.5
MIA
MIA SH3 domain containing
chr2_+_219514477 0.10 ENST00000347842.8
ENST00000358078.5
ASIC4
acid sensing ion channel subunit family member 4
chr6_+_44223770 0.10 ENST00000652453.1
ENST00000393841.6
ENST00000371724.6
ENST00000642777.1
ENST00000645692.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr11_-_68903796 0.10 ENST00000362034.7
MRPL21
mitochondrial ribosomal protein L21
chr1_+_2019324 0.10 ENST00000638411.1
ENST00000378585.7
ENST00000640067.1
GABRD
gamma-aminobutyric acid type A receptor subunit delta
chr19_-_37906646 0.09 ENST00000303868.5
WDR87
WD repeat domain 87
chr4_-_83334782 0.09 ENST00000681769.1
ENST00000513463.1
ENST00000311412.10
HPSE
heparanase
chr16_+_89686661 0.09 ENST00000505473.5
ENST00000353379.12
ENST00000625631.1
ENST00000564192.5
CDK10
cyclin dependent kinase 10
chr19_-_37906588 0.09 ENST00000447313.7
WDR87
WD repeat domain 87
chr1_+_2019379 0.09 ENST00000638771.1
ENST00000640949.1
ENST00000640030.1
GABRD
gamma-aminobutyric acid type A receptor subunit delta
chr19_+_13764502 0.09 ENST00000040663.8
ENST00000319545.12
MRI1
methylthioribose-1-phosphate isomerase 1
chr17_+_50834581 0.09 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr17_-_35119733 0.09 ENST00000460118.6
ENST00000335858.11
RAD51D
RAD51 paralog D
chr17_-_35119801 0.09 ENST00000592577.5
ENST00000590016.5
ENST00000345365.11
RAD51D
RAD51 paralog D
chr22_-_50526337 0.08 ENST00000651490.1
ENST00000543927.6
TYMP
SCO2
thymidine phosphorylase
synthesis of cytochrome C oxidase 2
chr12_+_109139397 0.08 ENST00000377854.9
ENST00000377848.7
ACACB
acetyl-CoA carboxylase beta
chr10_-_74163 0.07 ENST00000564130.2
TUBB8
tubulin beta 8 class VIII
chr20_-_46089905 0.07 ENST00000372291.3
ENST00000290231.11
NCOA5
nuclear receptor coactivator 5
chr19_-_10502745 0.06 ENST00000393623.6
KEAP1
kelch like ECH associated protein 1
chr5_-_132777229 0.06 ENST00000378721.8
ENST00000378719.7
ENST00000378701.5
SEPTIN8
septin 8
chr19_-_3061403 0.06 ENST00000586839.1
TLE5
TLE family member 5, transcriptional modulator
chr17_-_75182536 0.06 ENST00000578238.2
SUMO2
small ubiquitin like modifier 2
chr19_-_42255119 0.06 ENST00000222329.9
ENST00000594664.1
ERF
ENSG00000268643.2
ETS2 repressor factor
novel protein
chr8_+_117134989 0.05 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr21_+_36699100 0.05 ENST00000290399.11
SIM2
SIM bHLH transcription factor 2
chr8_+_117135259 0.05 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chrX_+_119236245 0.05 ENST00000535419.2
PGRMC1
progesterone receptor membrane component 1
chr5_+_172959416 0.05 ENST00000265100.6
ENST00000519239.5
RPL26L1
ribosomal protein L26 like 1
chr19_-_10503186 0.05 ENST00000592055.2
ENST00000171111.10
KEAP1
kelch like ECH associated protein 1
chr17_+_4771878 0.05 ENST00000270560.4
TM4SF5
transmembrane 4 L six family member 5
chr17_+_5486285 0.04 ENST00000576988.1
ENST00000576570.5
ENST00000573759.1
MIS12
MIS12 kinetochore complex component
chr9_-_136764515 0.04 ENST00000316144.6
LCN15
lipocalin 15
chr3_-_25783434 0.04 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chr1_-_246931892 0.04 ENST00000648844.2
AHCTF1
AT-hook containing transcription factor 1
chr19_+_1275508 0.03 ENST00000409293.6
FAM174C
family with sequence similarity 174 member C
chr1_-_160285120 0.03 ENST00000368072.10
PEX19
peroxisomal biogenesis factor 19
chrX_+_119236274 0.03 ENST00000217971.8
PGRMC1
progesterone receptor membrane component 1
chr18_+_3451647 0.03 ENST00000345133.9
ENST00000330513.10
ENST00000549546.5
TGIF1
TGFB induced factor homeobox 1
chr10_+_61901678 0.03 ENST00000644638.1
ENST00000681100.1
ENST00000279873.12
ARID5B
AT-rich interaction domain 5B
chr3_-_25783381 0.03 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr17_-_75182949 0.03 ENST00000314523.7
ENST00000420826.7
SUMO2
small ubiquitin like modifier 2
chr9_-_95516959 0.03 ENST00000437951.6
ENST00000430669.6
ENST00000468211.6
PTCH1
patched 1
chr10_-_125161019 0.03 ENST00000411419.6
CTBP2
C-terminal binding protein 2
chr12_+_54008961 0.02 ENST00000040584.6
HOXC8
homeobox C8
chr18_+_3451585 0.02 ENST00000551541.5
TGIF1
TGFB induced factor homeobox 1
chr1_-_42335189 0.02 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
FOXJ3
forkhead box J3
chr19_+_11798514 0.02 ENST00000323169.10
ENST00000450087.1
ZNF491
zinc finger protein 491
chr1_-_52552994 0.02 ENST00000355809.4
ENST00000528642.5
ENST00000470626.1
ENST00000257177.9
ENST00000371544.7
TUT4
terminal uridylyl transferase 4
chr1_-_42335869 0.01 ENST00000372573.5
FOXJ3
forkhead box J3
chr6_+_33204645 0.01 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr3_-_142963663 0.01 ENST00000340634.6
PAQR9
progestin and adipoQ receptor family member 9
chr16_+_69187125 0.01 ENST00000336278.8
SNTB2
syntrophin beta 2
chr4_+_163343882 0.00 ENST00000338566.8
NPY5R
neuropeptide Y receptor Y5
chr19_+_12945839 0.00 ENST00000586534.6
ENST00000316856.7
ENST00000592268.5
RAD23A
RAD23 homolog A, nucleotide excision repair protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0097338 response to clozapine(GO:0097338)
0.1 0.5 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.2 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.0 0.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:2000320 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.4 GO:0045008 depyrimidination(GO:0045008)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.2 GO:0036155 positive regulation of triglyceride catabolic process(GO:0010898) acylglycerol acyl-chain remodeling(GO:0036155)
0.0 0.2 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.0 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.1 GO:0016154 thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154)
0.0 0.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.2 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.2 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation