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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for GRHL1
Z-value: 0.69
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Transcription factors associated with GRHL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GRHL1 | hg38_v1_chr2_+_9951653_9951734 | 0.63 | 1.8e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_102642791 Show fit | 1.75 |
ENST00000340457.8
|
uroplakin 3B like 1 |
|
| chr7_-_102543849 Show fit | 1.67 |
ENST00000644544.1
|
uroplakin 3B like 2 |
|
| chr11_-_67674725 Show fit | 1.40 |
ENST00000525827.6
ENST00000673966.1 ENST00000673873.1 |
aldehyde dehydrogenase 3 family member B2 |
|
| chr11_-_67674606 Show fit | 1.33 |
ENST00000674110.1
ENST00000349015.7 |
aldehyde dehydrogenase 3 family member B2 |
|
| chr11_+_706595 Show fit | 1.15 |
ENST00000531348.5
ENST00000530636.5 |
EPS8 like 2 |
|
| chr1_-_24143112 Show fit | 1.15 |
ENST00000270800.2
|
interleukin 22 receptor subunit alpha 1 |
|
| chr7_+_76510608 Show fit | 1.10 |
ENST00000394849.1
|
uroplakin 3B |
|
| chr7_+_76510528 Show fit | 1.08 |
ENST00000334348.8
|
uroplakin 3B |
|
| chr2_-_85414039 Show fit | 1.08 |
ENST00000447219.6
ENST00000409670.5 ENST00000409724.5 |
capping actin protein, gelsolin like |
|
| chr7_+_76510516 Show fit | 1.07 |
ENST00000257632.9
|
uroplakin 3B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 1.7 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 1.6 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.0 | 1.2 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.1 | 1.1 | GO:0039536 | negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.1 | 1.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 1.0 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.1 | 0.9 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.3 | 0.8 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 0.3 | 0.8 | GO:0044771 | meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 0.8 | GO:0044393 | microspike(GO:0044393) |
| 0.1 | 0.8 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.2 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.0 | 0.2 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 0.2 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.1 | GO:0097636 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.3 | 1.7 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 1.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.2 | 1.2 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 1.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 0.8 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.1 | 0.8 | GO:0042835 | BRE binding(GO:0042835) |
| 0.0 | 0.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.7 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 0.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.2 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |