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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for GRHL1

Z-value: 0.69

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.18 GRHL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg38_v1_chr2_+_9951653_99517340.631.8e-04Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_-_102642791 1.75 ENST00000340457.8
UPK3BL1
uroplakin 3B like 1
chr7_-_102543849 1.67 ENST00000644544.1
UPK3BL2
uroplakin 3B like 2
chr11_-_67674725 1.40 ENST00000525827.6
ENST00000673966.1
ENST00000673873.1
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr11_-_67674606 1.33 ENST00000674110.1
ENST00000349015.7
ALDH3B2
aldehyde dehydrogenase 3 family member B2
chr11_+_706595 1.15 ENST00000531348.5
ENST00000530636.5
EPS8L2
EPS8 like 2
chr1_-_24143112 1.15 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr7_+_76510608 1.10 ENST00000394849.1
UPK3B
uroplakin 3B
chr7_+_76510528 1.08 ENST00000334348.8
UPK3B
uroplakin 3B
chr2_-_85414039 1.08 ENST00000447219.6
ENST00000409670.5
ENST00000409724.5
CAPG
capping actin protein, gelsolin like
chr7_+_76510516 1.07 ENST00000257632.9
UPK3B
uroplakin 3B
chr1_-_201399302 0.98 ENST00000633953.1
ENST00000391967.7
LAD1
ladinin 1
chr7_-_80922354 0.96 ENST00000419255.6
SEMA3C
semaphorin 3C
chr14_-_80211268 0.93 ENST00000556811.5
DIO2
iodothyronine deiodinase 2
chr3_+_101849505 0.86 ENST00000326151.9
ENST00000326172.9
NFKBIZ
NFKB inhibitor zeta
chr10_+_103277129 0.83 ENST00000369849.9
INA
internexin neuronal intermediate filament protein alpha
chr2_+_95274439 0.83 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
PROM2
prominin 2
chr14_-_80211472 0.80 ENST00000557125.1
ENST00000438257.9
ENST00000422005.7
DIO2
iodothyronine deiodinase 2
chr11_+_65787056 0.76 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chr2_+_113058637 0.76 ENST00000346807.7
IL36RN
interleukin 36 receptor antagonist
chr9_+_5450503 0.74 ENST00000381573.8
ENST00000381577.4
CD274
CD274 molecule
chr8_-_129786617 0.73 ENST00000276708.9
GSDMC
gasdermin C
chr20_-_62427528 0.70 ENST00000252998.2
RBBP8NL
RBBP8 N-terminal like
chr11_+_76782250 0.57 ENST00000533752.1
ENST00000612930.1
TSKU
tsukushi, small leucine rich proteoglycan
chr5_+_181040260 0.55 ENST00000515271.1
ENST00000327705.14
BTNL9
butyrophilin like 9
chr1_-_28058087 0.54 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr11_+_119168188 0.53 ENST00000454811.5
ENST00000409265.8
ENST00000449394.5
NLRX1
NLR family member X1
chr11_+_119168705 0.53 ENST00000409109.6
ENST00000409991.5
ENST00000292199.6
NLRX1
NLR family member X1
chr1_-_153608136 0.52 ENST00000368703.6
S100A16
S100 calcium binding protein A16
chr1_+_34782259 0.51 ENST00000373362.3
GJB3
gap junction protein beta 3
chr15_+_41838839 0.50 ENST00000458483.4
PLA2G4B
phospholipase A2 group IVB
chr19_-_35490456 0.49 ENST00000338897.4
ENST00000484218.6
KRTDAP
keratinocyte differentiation associated protein
chr20_-_25339731 0.48 ENST00000450393.5
ENST00000491682.5
ABHD12
abhydrolase domain containing 12, lysophospholipase
chr9_+_69121259 0.47 ENST00000643713.1
ENST00000606364.5
TJP2
tight junction protein 2
chr18_-_37565825 0.47 ENST00000603232.6
CELF4
CUGBP Elav-like family member 4
chr19_-_15479469 0.46 ENST00000292609.8
ENST00000340880.5
PGLYRP2
peptidoglycan recognition protein 2
chr11_+_706117 0.45 ENST00000533256.5
ENST00000614442.4
EPS8L2
EPS8 like 2
chr9_+_69123009 0.42 ENST00000647986.1
TJP2
tight junction protein 2
chr15_+_41559189 0.42 ENST00000263798.8
TYRO3
TYRO3 protein tyrosine kinase
chr11_-_11353241 0.42 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr9_+_75088498 0.41 ENST00000346234.7
OSTF1
osteoclast stimulating factor 1
chr3_+_52211442 0.40 ENST00000459884.1
ALAS1
5'-aminolevulinate synthase 1
chr1_-_32901330 0.35 ENST00000329151.5
ENST00000373463.8
TMEM54
transmembrane protein 54
chr9_-_75088198 0.34 ENST00000376808.8
NMRK1
nicotinamide riboside kinase 1
chr18_+_9474994 0.34 ENST00000019317.8
RALBP1
ralA binding protein 1
chr19_+_10625507 0.33 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
SLC44A2
solute carrier family 44 member 2
chr2_+_167248638 0.33 ENST00000295237.10
XIRP2
xin actin binding repeat containing 2
chr4_+_155667096 0.33 ENST00000393832.7
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr4_+_155666718 0.31 ENST00000621234.4
ENST00000511108.5
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr18_+_9475494 0.30 ENST00000383432.8
RALBP1
ralA binding protein 1
chr4_+_155666963 0.30 ENST00000455639.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr6_+_32153441 0.30 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
PPT2
palmitoyl-protein thioesterase 2
chr19_-_17245889 0.30 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr7_-_139109337 0.29 ENST00000464606.5
ZC3HAV1
zinc finger CCCH-type containing, antiviral 1
chr3_-_49104745 0.28 ENST00000635194.1
ENST00000306125.12
ENST00000634602.1
ENST00000414533.5
ENST00000635443.1
ENST00000452739.5
ENST00000635231.1
QARS1
glutaminyl-tRNA synthetase 1
chr4_+_155667198 0.24 ENST00000296518.11
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr15_+_66386902 0.24 ENST00000307102.10
MAP2K1
mitogen-activated protein kinase kinase 1
chr2_-_208254232 0.23 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chr1_+_43974902 0.22 ENST00000532642.5
ENST00000236067.8
ENST00000471859.6
ENST00000472174.7
ATP6V0B
ATPase H+ transporting V0 subunit b
chr12_-_3753091 0.22 ENST00000252322.1
ENST00000440314.7
CRACR2A
calcium release activated channel regulator 2A
chr19_+_57527316 0.22 ENST00000240719.7
ENST00000376233.8
ENST00000594943.1
ENST00000602149.1
ZNF549
zinc finger protein 549
chr14_-_23071617 0.20 ENST00000357481.6
ACIN1
apoptotic chromatin condensation inducer 1
chr12_+_18261511 0.20 ENST00000538779.6
ENST00000433979.6
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr11_-_65780917 0.19 ENST00000532090.3
AP5B1
adaptor related protein complex 5 subunit beta 1
chr4_+_155666827 0.19 ENST00000511507.5
ENST00000506455.6
GUCY1A1
guanylate cyclase 1 soluble subunit alpha 1
chr6_-_31139063 0.17 ENST00000259845.5
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr12_+_56104527 0.14 ENST00000552766.5
ENST00000303305.11
PA2G4
proliferation-associated 2G4
chrX_-_120469282 0.14 ENST00000200639.9
ENST00000371335.4
LAMP2
lysosomal associated membrane protein 2
chr5_+_134967901 0.13 ENST00000282611.8
CATSPER3
cation channel sperm associated 3
chr1_+_156061142 0.12 ENST00000361084.10
RAB25
RAB25, member RAS oncogene family
chr11_-_120138104 0.11 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr1_-_16212598 0.11 ENST00000270747.8
ARHGEF19
Rho guanine nucleotide exchange factor 19
chr18_-_37565765 0.11 ENST00000361795.9
ENST00000420428.7
CELF4
CUGBP Elav-like family member 4
chr18_-_37565714 0.11 ENST00000591287.5
ENST00000601019.5
ENST00000601392.5
CELF4
CUGBP Elav-like family member 4
chr18_-_37565628 0.10 ENST00000334919.9
ENST00000591282.5
ENST00000588597.5
CELF4
CUGBP Elav-like family member 4
chrX_+_147911910 0.10 ENST00000370475.9
FMR1
FMRP translational regulator 1
chr18_+_9475450 0.10 ENST00000585015.6
RALBP1
ralA binding protein 1
chr10_-_50885619 0.09 ENST00000373997.8
A1CF
APOBEC1 complementation factor
chrX_+_147912039 0.09 ENST00000334557.10
ENST00000439526.6
FMR1
FMRP translational regulator 1
chr4_-_128288791 0.07 ENST00000613358.4
ENST00000520121.6
PGRMC2
progesterone receptor membrane component 2
chr6_-_43059367 0.07 ENST00000230413.9
ENST00000487429.1
ENST00000388752.8
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr10_-_50885656 0.05 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr1_+_94418435 0.05 ENST00000647998.2
ABCD3
ATP binding cassette subfamily D member 3
chr7_-_124765753 0.04 ENST00000303921.3
GPR37
G protein-coupled receptor 37
chr10_+_80079036 0.04 ENST00000372273.7
TMEM254
transmembrane protein 254
chr1_-_36397880 0.03 ENST00000315732.3
LSM10
LSM10, U7 small nuclear RNA associated
chr22_+_18077976 0.02 ENST00000399744.8
PEX26
peroxisomal biogenesis factor 26
chr16_+_2514253 0.01 ENST00000565223.1
ATP6V0C
ATPase H+ transporting V0 subunit c
chr18_-_57803307 0.01 ENST00000648908.2
ATP8B1
ATPase phospholipid transporting 8B1
chr19_-_14835252 0.00 ENST00000641666.1
ENST00000642030.1
ENST00000642000.1
OR7C1
olfactory receptor family 7 subfamily C member 1
chr14_-_23071538 0.00 ENST00000555566.1
ENST00000338631.10
ENST00000557515.5
ENST00000397341.7
ACIN1
apoptotic chromatin condensation inducer 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.3 0.8 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 1.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 0.5 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.7 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.5 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 2.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 1.7 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.8 GO:0019732 antifungal humoral response(GO:0019732)
0.1 0.9 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.1 1.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.8 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.2 GO:1901254 modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
0.1 1.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.2 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.4 GO:0060068 vagina development(GO:0060068)
0.0 0.3 GO:0015871 choline transport(GO:0015871)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.5 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 1.2 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.1 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740)
0.0 0.0 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153) detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0044393 microspike(GO:0044393)
0.1 1.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.2 GO:1902737 dendritic filopodium(GO:1902737)
0.1 0.8 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 2.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.5 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 1.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 2.7 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.8 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.8 GO:0042835 BRE binding(GO:0042835)
0.1 0.5 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.3 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.4 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 1.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.0 GO:0036505 prosaposin receptor activity(GO:0036505)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins