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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HDX

Z-value: 0.24

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.14 HDX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg38_v1_chrX_-_84502442_845025010.319.4e-02Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_112836702 1.06 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
IL1B
interleukin 1 beta
chr1_-_205422050 0.60 ENST00000367153.9
LEMD1
LEM domain containing 1
chr18_+_31447732 0.46 ENST00000257189.5
DSG3
desmoglein 3
chr1_+_84164370 0.42 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_+_112977998 0.41 ENST00000259205.5
ENST00000376489.6
IL36G
interleukin 36 gamma
chr9_+_6215786 0.27 ENST00000417746.6
ENST00000682010.1
IL33
interleukin 33
chr7_+_129368123 0.26 ENST00000460109.5
ENST00000474594.5
AHCYL2
adenosylhomocysteinase like 2
chr19_-_41428730 0.22 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_-_153390976 0.22 ENST00000368732.5
ENST00000368733.4
S100A8
S100 calcium binding protein A8
chr5_-_35230332 0.21 ENST00000504500.5
PRLR
prolactin receptor
chr10_-_14330879 0.20 ENST00000357447.7
FRMD4A
FERM domain containing 4A
chr2_+_127646145 0.18 ENST00000486700.2
ENST00000272644.7
GPR17
G protein-coupled receptor 17
chr2_+_127645864 0.16 ENST00000544369.5
GPR17
G protein-coupled receptor 17
chr3_-_165837412 0.14 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr1_-_209652329 0.13 ENST00000367030.7
ENST00000356082.9
LAMB3
laminin subunit beta 3
chr2_-_191020960 0.11 ENST00000432058.1
STAT1
signal transducer and activator of transcription 1
chr14_+_79279681 0.10 ENST00000679122.1
NRXN3
neurexin 3
chr1_+_117060309 0.09 ENST00000369466.9
TTF2
transcription termination factor 2
chr14_+_79279339 0.09 ENST00000557594.5
NRXN3
neurexin 3
chr1_-_110519175 0.08 ENST00000369771.4
KCNA10
potassium voltage-gated channel subfamily A member 10
chr2_+_169069537 0.08 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr1_-_169711603 0.08 ENST00000236147.6
ENST00000650983.1
SELL
selectin L
chr12_-_118359639 0.08 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr12_+_10307950 0.07 ENST00000543420.5
ENST00000543777.5
KLRD1
killer cell lectin like receptor D1
chr7_+_142800957 0.07 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr12_+_10307818 0.06 ENST00000350274.9
ENST00000336164.9
KLRD1
killer cell lectin like receptor D1
chr9_+_35538619 0.06 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr7_-_135728177 0.06 ENST00000682651.1
ENST00000354042.8
SLC13A4
solute carrier family 13 member 4
chr1_+_62597510 0.06 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chrX_+_55623400 0.06 ENST00000339140.5
FOXR2
forkhead box R2
chr14_+_79279403 0.06 ENST00000281127.11
NRXN3
neurexin 3
chr14_+_79279906 0.05 ENST00000428277.6
NRXN3
neurexin 3
chr1_-_10964201 0.05 ENST00000418570.6
C1orf127
chromosome 1 open reading frame 127
chr12_+_56763316 0.05 ENST00000322165.1
HSD17B6
hydroxysteroid 17-beta dehydrogenase 6
chr20_-_37158904 0.05 ENST00000417458.5
MROH8
maestro heat like repeat family member 8
chr7_+_80135694 0.05 ENST00000457358.7
GNAI1
G protein subunit alpha i1
chr12_+_54028433 0.04 ENST00000243108.5
HOXC6
homeobox C6
chr1_+_197268222 0.04 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
CRB1
crumbs cell polarity complex component 1
chr10_+_18400562 0.04 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr5_-_35230467 0.04 ENST00000515839.1
ENST00000618457.5
PRLR
prolactin receptor
chr18_+_58362467 0.04 ENST00000675101.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr4_+_70334963 0.03 ENST00000273936.6
CABS1
calcium binding protein, spermatid associated 1
chr11_+_9664061 0.01 ENST00000447399.6
ENST00000318950.11
SWAP70
switching B cell complex subunit SWAP70
chr5_+_141370236 0.01 ENST00000576222.2
ENST00000618934.1
PCDHGB3
protocadherin gamma subfamily B, 3
chr16_+_1827203 0.00 ENST00000615972.1
FAHD1
fumarylacetoacetate hydrolase domain containing 1
chr1_-_159714581 0.00 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr3_+_107523026 0.00 ENST00000416476.6
BBX
BBX high mobility group box domain containing

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.3 GO:0061518 microglial cell activation involved in immune response(GO:0002282) macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0032119 sequestering of zinc ion(GO:0032119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB