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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HIC2
Z-value: 1.57
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Transcription factors associated with HIC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIC2 | hg38_v1_chr22_+_21420636_21420669 | 0.43 | 1.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIC2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 8.7 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.5 | 8.5 | GO:0035878 | nail development(GO:0035878) |
| 1.2 | 7.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.2 | 7.0 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
| 0.6 | 6.5 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.3 | 6.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 6.0 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 6.0 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 5.7 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.8 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.2 | 10.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.4 | 9.4 | GO:0030056 | hemidesmosome(GO:0030056) |
| 1.1 | 7.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 6.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 6.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 5.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 5.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 5.2 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.4 | 4.6 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 10.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 9.9 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.7 | 8.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.3 | 6.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 5.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 5.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.1 | 5.0 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.9 | 4.4 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 13.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 9.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 9.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 9.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 7.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 7.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 6.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 5.5 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.1 | 5.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 7.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 7.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 6.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 6.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 5.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 5.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 4.5 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.0 | 4.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.9 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |