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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HMGA2

Z-value: 0.42

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.14 HMGA2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg38_v1_chr12_+_65824475_658245240.478.5e-03Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_215393126 2.29 ENST00000456923.5
FN1
fibronectin 1
chr7_+_80638510 0.67 ENST00000433696.6
ENST00000538969.5
ENST00000544133.5
CD36
CD36 molecule
chr7_+_80638662 0.64 ENST00000394788.7
CD36
CD36 molecule
chr10_-_127892930 0.46 ENST00000368671.4
CLRN3
clarin 3
chr20_-_56497608 0.44 ENST00000617620.1
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr3_+_122055355 0.42 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr7_+_80638633 0.41 ENST00000447544.7
ENST00000482059.6
CD36
CD36 molecule
chr4_+_78551733 0.38 ENST00000512884.5
ENST00000512542.5
ENST00000503570.6
ENST00000264908.11
ANXA3
annexin A3
chrX_+_2752024 0.35 ENST00000644266.2
ENST00000419513.7
ENST00000509484.3
ENST00000381174.10
XG
Xg glycoprotein (Xg blood group)
chrX_-_7927701 0.33 ENST00000537427.5
ENST00000444736.5
ENST00000442940.1
PNPLA4
patatin like phospholipase domain containing 4
chr18_-_14132423 0.33 ENST00000589498.5
ENST00000590202.3
ZNF519
zinc finger protein 519
chr6_+_106087580 0.33 ENST00000424894.1
ENST00000648754.1
PRDM1
PR/SET domain 1
chrX_-_7927375 0.30 ENST00000381042.9
PNPLA4
patatin like phospholipase domain containing 4
chr16_-_20404731 0.29 ENST00000302451.9
PDILT
protein disulfide isomerase like, testis expressed
chr2_-_162152404 0.28 ENST00000375497.3
GCG
glucagon
chr2_-_89143133 0.26 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr14_-_64942783 0.26 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr12_+_69585434 0.26 ENST00000299300.11
ENST00000544368.6
CCT2
chaperonin containing TCP1 subunit 2
chr22_-_18936142 0.25 ENST00000438924.5
ENST00000457083.1
ENST00000357068.11
ENST00000420436.5
ENST00000334029.6
ENST00000610940.4
PRODH
proline dehydrogenase 1
chr15_-_32403195 0.25 ENST00000512626.2
GOLGA8K
golgin A8 family member K
chr10_-_5003850 0.25 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chr12_-_122266410 0.24 ENST00000451053.3
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
chr12_+_18261511 0.24 ENST00000538779.6
ENST00000433979.6
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr17_-_40755328 0.24 ENST00000312150.5
KRT25
keratin 25
chr19_-_42594918 0.23 ENST00000244336.10
CEACAM8
CEA cell adhesion molecule 8
chrX_+_23908006 0.22 ENST00000379211.8
ENST00000648352.1
CXorf58
chromosome X open reading frame 58
chr3_+_155083523 0.21 ENST00000680057.1
MME
membrane metalloendopeptidase
chr6_+_111259294 0.21 ENST00000672303.1
ENST00000671876.2
ENST00000368847.5
MFSD4B
major facilitator superfamily domain containing 4B
chrX_-_154295085 0.21 ENST00000617225.4
ENST00000619903.4
TEX28
testis expressed 28
chr12_-_10172117 0.19 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
OLR1
oxidized low density lipoprotein receptor 1
chr6_+_111259474 0.18 ENST00000672554.1
ENST00000673024.1
MFSD4B
major facilitator superfamily domain containing 4B
chr8_+_52939182 0.18 ENST00000674939.1
NPBWR1
neuropeptides B and W receptor 1
chr11_-_125778818 0.18 ENST00000358524.8
PATE2
prostate and testis expressed 2
chr11_-_125778788 0.17 ENST00000436890.2
PATE2
prostate and testis expressed 2
chr13_+_50909905 0.17 ENST00000644034.1
ENST00000645955.1
RNASEH2B
ribonuclease H2 subunit B
chr2_-_85888685 0.17 ENST00000638178.1
ENST00000640982.1
ENST00000640992.1
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr19_+_43951216 0.17 ENST00000591168.5
ENST00000587682.6
ENST00000251269.9
ZNF221
zinc finger protein 221
chr17_-_445939 0.16 ENST00000329099.4
RFLNB
refilin B
chr11_-_19201976 0.16 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr12_+_8157034 0.15 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr8_-_54101458 0.15 ENST00000521352.5
ENST00000618741.1
LYPLA1
lysophospholipase 1
chr14_-_68979314 0.15 ENST00000684713.1
ENST00000683198.1
ENST00000684598.1
ENST00000682331.1
ENST00000682291.1
ENST00000683342.1
ACTN1
actinin alpha 1
chr17_-_3398410 0.14 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr19_-_11346259 0.14 ENST00000590788.1
ENST00000354882.10
ENST00000586590.5
ENST00000589555.5
ENST00000586956.5
ENST00000593256.6
ENST00000447337.5
ENST00000591677.5
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr11_-_19202004 0.13 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr2_-_287320 0.13 ENST00000401503.5
ALKAL2
ALK and LTK ligand 2
chr14_+_99481395 0.13 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
CCNK
cyclin K
chr20_+_56392607 0.13 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr10_+_35167516 0.13 ENST00000361599.8
CREM
cAMP responsive element modulator
chrX_-_23907887 0.12 ENST00000379226.9
APOO
apolipoprotein O
chr15_-_74367637 0.12 ENST00000268053.11
ENST00000416978.1
CYP11A1
cytochrome P450 family 11 subfamily A member 1
chr6_-_127343518 0.12 ENST00000528402.5
ENST00000454591.6
ECHDC1
ethylmalonyl-CoA decarboxylase 1
chr20_-_33401501 0.12 ENST00000473997.5
ENST00000346416.7
ENST00000357886.8
ENST00000339269.5
CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr19_+_41376560 0.11 ENST00000436170.6
TMEM91
transmembrane protein 91
chr6_-_117573571 0.11 ENST00000467125.1
ENSG00000282218.1
novel protein, GOPC-ROS1 readthrough
chr2_-_287299 0.11 ENST00000405290.5
ALKAL2
ALK and LTK ligand 2
chr21_-_30480364 0.11 ENST00000390689.3
KRTAP19-1
keratin associated protein 19-1
chr2_-_55334529 0.10 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
CCDC88A
coiled-coil domain containing 88A
chr10_+_84424919 0.10 ENST00000543283.2
ENST00000494586.5
CCSER2
coiled-coil serine rich protein 2
chr6_-_33322803 0.10 ENST00000446511.1
ENST00000446403.1
ENST00000374542.10
ENST00000266000.10
ENST00000414083.6
ENST00000620164.4
DAXX
death domain associated protein
chr8_+_33485173 0.10 ENST00000360128.11
MAK16
MAK16 homolog
chr12_-_8612850 0.10 ENST00000229335.11
ENST00000537228.5
AICDA
activation induced cytidine deaminase
chr2_+_171687409 0.09 ENST00000452242.5
ENST00000340296.8
DYNC1I2
dynein cytoplasmic 1 intermediate chain 2
chr8_-_104467042 0.09 ENST00000521573.2
ENST00000351513.7
DPYS
dihydropyrimidinase
chr19_-_12365628 0.09 ENST00000438182.5
ZNF442
zinc finger protein 442
chr1_+_196977550 0.09 ENST00000256785.5
CFHR5
complement factor H related 5
chr6_-_127343590 0.09 ENST00000368291.6
ENST00000454859.8
ECHDC1
ethylmalonyl-CoA decarboxylase 1
chr2_-_182522703 0.08 ENST00000410103.1
PDE1A
phosphodiesterase 1A
chr1_-_21113129 0.08 ENST00000684485.1
EIF4G3
eukaryotic translation initiation factor 4 gamma 3
chr20_+_47501929 0.07 ENST00000371997.3
NCOA3
nuclear receptor coactivator 3
chr19_+_41376499 0.06 ENST00000392002.7
TMEM91
transmembrane protein 91
chrX_-_77895546 0.06 ENST00000358075.11
MAGT1
magnesium transporter 1
chrX_-_13319952 0.06 ENST00000622204.1
ENST00000380622.5
ATXN3L
ataxin 3 like
chr2_-_54987578 0.05 ENST00000486085.5
RTN4
reticulon 4
chrX_+_118346072 0.05 ENST00000371822.9
ENST00000254029.8
ENST00000371825.7
WDR44
WD repeat domain 44
chr2_+_171687501 0.05 ENST00000508530.5
DYNC1I2
dynein cytoplasmic 1 intermediate chain 2
chr20_+_47501875 0.05 ENST00000371998.8
ENST00000372004.7
NCOA3
nuclear receptor coactivator 3
chr12_-_122266425 0.05 ENST00000643696.1
ENST00000267199.9
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
chr15_+_84235773 0.05 ENST00000510439.7
ENST00000422563.6
GOLGA6L4
golgin A6 family like 4
chr2_+_171687672 0.04 ENST00000409197.5
ENST00000456808.5
ENST00000409317.5
ENST00000409773.5
ENST00000411953.5
ENST00000409453.5
DYNC1I2
dynein cytoplasmic 1 intermediate chain 2
chr11_+_94567362 0.04 ENST00000299001.11
PIWIL4
piwi like RNA-mediated gene silencing 4
chr15_-_82349437 0.04 ENST00000621197.4
ENST00000610657.2
ENST00000619556.4
GOLGA6L10
golgin A6 family like 10
chr3_+_98166696 0.03 ENST00000641450.1
OR5H15
olfactory receptor family 5 subfamily H member 15
chrX_-_72572794 0.03 ENST00000421523.6
ENST00000648036.1
ENST00000373559.8
ENST00000648139.1
ENST00000650636.1
ENST00000648962.1
ENST00000373560.7
ENST00000373568.7
ENST00000373573.9
ENST00000647654.1
ENST00000647859.1
ENST00000415409.6
ENST00000648298.1
ENST00000649752.1
ENST00000373571.6
ENST00000647980.1
ENST00000650126.1
ENST00000373554.6
ENST00000648870.1
ENST00000373556.8
ENST00000647886.1
ENST00000648452.1
ENST00000647594.1
ENST00000373583.6
ENST00000648922.1
HDAC8
ENSG00000285547.1
histone deacetylase 8
novel protein
chr19_-_10565990 0.03 ENST00000539027.5
ENST00000312962.12
ENST00000543682.3
ENST00000652042.1
ENST00000432197.5
KRI1
KRI1 homolog
chr18_+_11851404 0.03 ENST00000526991.3
CHMP1B
charged multivesicular body protein 1B
chr2_+_169827432 0.02 ENST00000272793.11
UBR3
ubiquitin protein ligase E3 component n-recognin 3
chr2_+_234978685 0.02 ENST00000409212.5
ENST00000344528.8
ENST00000444916.5
SH3BP4
SH3 domain binding protein 4
chr6_+_29585121 0.02 ENST00000641840.1
OR2H2
olfactory receptor family 2 subfamily H member 2
chr17_-_52158678 0.02 ENST00000451037.7
CA10
carbonic anhydrase 10
chr2_-_182522556 0.01 ENST00000435564.5
PDE1A
phosphodiesterase 1A
chr17_+_75234704 0.01 ENST00000579838.1
NUP85
nucleoporin 85
chr6_+_116571477 0.01 ENST00000487832.6
ENST00000466444.7
ENST00000518117.5
RWDD1
RWD domain containing 1
chr19_-_37655409 0.00 ENST00000591444.1
ENST00000351218.6
ENST00000684514.1
ENST00000587809.5
ZFP30
ZFP30 zinc finger protein
chr1_+_197917355 0.00 ENST00000367388.4
ENST00000367387.6
LHX9
LIM homeobox 9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.7 GO:0070543 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.4 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.1 0.3 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.1 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.3 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
0.1 0.2 GO:0070378 positive regulation of ERK5 cascade(GO:0070378)
0.1 0.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.2 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.0 0.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0006212 uracil catabolic process(GO:0006212)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0035624 receptor transactivation(GO:0035624)
0.0 0.1 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 0.6 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.4 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0071753 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.0 1.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.6 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.2 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.2 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.2 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.0 2.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.7 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin