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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXA4

Z-value: 0.32

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
ENSG00000197576.14 HOXA4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg38_v1_chr7_-_27130733_27130780-0.478.0e-03Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_41055211 0.62 ENST00000542910.1
ENST00000398477.1
keratin associated protein 2-2
chr5_+_53480619 0.44 ENST00000396947.7
ENST00000256759.8
follistatin
chr12_-_119803383 0.31 ENST00000392520.2
ENST00000678677.1
ENST00000679249.1
ENST00000676849.1
citron rho-interacting serine/threonine kinase
chr2_-_68871382 0.31 ENST00000295379.2
bone morphogenetic protein 10
chr3_-_42702778 0.31 ENST00000457462.5
ENST00000441594.6
hedgehog acyltransferase like
chr2_+_127646145 0.30 ENST00000486700.2
ENST00000272644.7
G protein-coupled receptor 17
chr2_+_127645864 0.30 ENST00000544369.5
G protein-coupled receptor 17
chr3_-_52452828 0.27 ENST00000496590.1
troponin C1, slow skeletal and cardiac type
chr8_-_10655137 0.26 ENST00000382483.4
RP1 like 1
chr11_+_112175526 0.22 ENST00000532612.5
ENST00000438022.5
beta-carotene oxygenase 2
chr13_-_46142834 0.22 ENST00000674665.1
lymphocyte cytosolic protein 1
chr3_+_159839847 0.21 ENST00000445224.6
schwannomin interacting protein 1
chr12_-_86256267 0.21 ENST00000620241.4
MGAT4 family member C
chr12_+_29223730 0.20 ENST00000547116.5
fatty acyl-CoA reductase 2
chr12_+_29223659 0.20 ENST00000182377.8
fatty acyl-CoA reductase 2
chr8_+_22567038 0.20 ENST00000523348.1
sorbin and SH3 domain containing 3
chr11_+_112175501 0.20 ENST00000357685.11
ENST00000361053.8
beta-carotene oxygenase 2
chrX_+_41688967 0.19 ENST00000378142.9
G protein-coupled receptor 34
chr17_-_10549694 0.18 ENST00000622564.4
myosin heavy chain 2
chr15_+_51377247 0.18 ENST00000396399.6
gliomedin
chr6_+_99606833 0.17 ENST00000369215.5
PR/SET domain 13
chrX_+_41689006 0.17 ENST00000378138.5
ENST00000620846.1
ENST00000649219.1
G protein-coupled receptor 34
chr6_+_50818701 0.17 ENST00000344788.7
transcription factor AP-2 beta
chr6_+_12716760 0.15 ENST00000332995.12
phosphatase and actin regulator 1
chr5_+_141430565 0.15 ENST00000613314.1
protocadherin gamma subfamily A, 12
chr1_-_41918858 0.14 ENST00000372583.6
HIVEP zinc finger 3
chr2_+_53767772 0.14 ENST00000295304.5
ChaC glutathione specific gamma-glutamylcyclotransferase 2
chr4_+_83536097 0.13 ENST00000395226.6
ENST00000264409.5
glycerol-3-phosphate acyltransferase 3
chr13_-_83882456 0.13 ENST00000674365.1
SLIT and NTRK like family member 1
chr2_-_190062721 0.13 ENST00000260950.5
myostatin
chr1_-_41918666 0.13 ENST00000372584.5
HIVEP zinc finger 3
chr17_-_10549612 0.13 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr13_-_83882390 0.13 ENST00000377084.3
SLIT and NTRK like family member 1
chr7_-_13986439 0.13 ENST00000443608.5
ENST00000438956.5
ETS variant transcription factor 1
chr8_-_94436926 0.12 ENST00000481490.3
fibrinogen silencer binding protein
chr2_-_2324323 0.12 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr6_+_12716801 0.12 ENST00000674595.1
phosphatase and actin regulator 1
chr19_+_12838437 0.12 ENST00000251472.9
microtubule associated serine/threonine kinase 1
chr6_+_12716554 0.12 ENST00000676159.1
phosphatase and actin regulator 1
chr7_-_13989658 0.12 ENST00000430479.6
ENST00000433547.1
ENST00000405192.6
ETS variant transcription factor 1
chr11_-_5343524 0.11 ENST00000300773.3
olfactory receptor family 51 subfamily B member 5
chr1_-_100178215 0.11 ENST00000370138.1
ENST00000370137.6
ENST00000342895.7
ENST00000620882.4
leucine rich repeat containing 39
chr6_-_116829037 0.11 ENST00000368549.7
ENST00000530250.1
ENST00000310357.8
G protein-coupled receptor class C group 6 member A
chr5_-_1882902 0.11 ENST00000231357.7
iroquois homeobox 4
chr5_+_153491174 0.11 ENST00000521843.6
glutamate ionotropic receptor AMPA type subunit 1
chrX_-_19670983 0.11 ENST00000379716.5
SH3 domain containing kinase binding protein 1
chr22_+_25742141 0.11 ENST00000536101.5
ENST00000335473.12
ENST00000407587.6
myosin XVIIIB
chr2_-_80304274 0.10 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
leucine rich repeat transmembrane neuronal 1
chr17_-_69141878 0.10 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr17_-_10549652 0.10 ENST00000245503.10
myosin heavy chain 2
chr3_-_179266971 0.10 ENST00000349697.2
ENST00000497599.5
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr2_-_80304700 0.10 ENST00000295057.4
leucine rich repeat transmembrane neuronal 1
chr2_-_55334529 0.09 ENST00000645860.1
ENST00000642563.1
ENST00000647396.1
coiled-coil domain containing 88A
chr7_-_13986498 0.09 ENST00000420159.6
ENST00000399357.7
ENST00000403527.5
ETS variant transcription factor 1
chr1_-_151790475 0.09 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr9_-_110579704 0.09 ENST00000374469.6
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr20_+_33562306 0.09 ENST00000344201.7
CBFA2/RUNX1 partner transcriptional co-repressor 2
chr15_+_74788542 0.09 ENST00000567571.5
C-terminal Src kinase
chr5_+_153490727 0.09 ENST00000340592.9
glutamate ionotropic receptor AMPA type subunit 1
chr12_+_56128217 0.09 ENST00000267113.4
ENST00000394048.10
extended synaptotagmin 1
chr11_-_69819410 0.09 ENST00000334134.4
fibroblast growth factor 3
chr12_-_95073490 0.09 ENST00000330677.7
nuclear receptor subfamily 2 group C member 1
chr17_-_10421944 0.08 ENST00000403437.2
myosin heavy chain 8
chr7_+_144355288 0.08 ENST00000498580.5
ENST00000056217.10
Rho guanine nucleotide exchange factor 5
chr10_-_67696115 0.08 ENST00000433211.7
catenin alpha 3
chr11_+_128693887 0.08 ENST00000281428.12
Fli-1 proto-oncogene, ETS transcription factor
chr12_+_12785652 0.08 ENST00000356591.5
apolipoprotein L domain containing 1
chr18_-_31162849 0.08 ENST00000257197.7
ENST00000257198.6
desmocollin 1
chr1_+_155689074 0.08 ENST00000343043.7
ENST00000421487.6
ENST00000535183.5
ENST00000368336.10
ENST00000465375.5
ENST00000470830.5
death associated protein 3
chr8_-_98942557 0.08 ENST00000523601.5
serine/threonine kinase 3
chr5_+_70025247 0.07 ENST00000380751.9
ENST00000380750.8
ENST00000503931.5
ENST00000506542.1
small EDRK-rich factor 1B
chr7_-_13988863 0.07 ENST00000405358.8
ETS variant transcription factor 1
chr8_-_28490220 0.07 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
F-box protein 16
chr12_-_91004965 0.07 ENST00000261172.8
epiphycan
chr11_+_128694052 0.07 ENST00000527786.7
ENST00000534087.3
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_5351508 0.07 ENST00000380219.1
olfactory receptor family 51 subfamily B member 6
chr5_+_153490655 0.07 ENST00000518142.5
ENST00000285900.10
glutamate ionotropic receptor AMPA type subunit 1
chrX_-_54998530 0.07 ENST00000545676.5
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr2_-_2324642 0.06 ENST00000650485.1
ENST00000649207.1
myelin transcription factor 1 like
chr12_+_106582996 0.06 ENST00000392842.6
regulatory factor X4
chr7_-_29195186 0.06 ENST00000449801.5
ENST00000409850.5
carboxypeptidase vitellogenic like
chrX_+_135520616 0.06 ENST00000370752.4
ENST00000639893.2
integrator complex subunit 6 like
chr18_-_63158208 0.06 ENST00000678301.1
BCL2 apoptosis regulator
chr12_+_53425070 0.06 ENST00000550839.1
anti-Mullerian hormone receptor type 2
chr9_-_110999458 0.06 ENST00000374430.6
lysophosphatidic acid receptor 1
chr10_-_100065394 0.06 ENST00000441382.1
carboxypeptidase N subunit 1
chr7_+_107470050 0.06 ENST00000304402.6
G protein-coupled receptor 22
chr6_+_50818857 0.05 ENST00000393655.4
transcription factor AP-2 beta
chr1_+_213988501 0.05 ENST00000261454.8
ENST00000435016.2
prospero homeobox 1
chr14_-_80231052 0.05 ENST00000557010.5
iodothyronine deiodinase 2
chr1_+_28259473 0.05 ENST00000253063.4
sestrin 2
chr9_-_110579880 0.05 ENST00000401783.6
ENST00000374461.1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr5_+_148203024 0.05 ENST00000325630.3
serine peptidase inhibitor Kazal type 6
chr12_-_95073580 0.05 ENST00000393101.7
ENST00000333003.10
ENST00000622476.4
nuclear receptor subfamily 2 group C member 1
chr10_-_93702508 0.05 ENST00000359204.5
FRA10A associated CGG repeat 1
chr17_+_56153458 0.05 ENST00000318698.6
ENST00000682825.1
ENST00000566473.6
ankyrin repeat and fibronectin type III domain containing 1
chrX_+_37780049 0.04 ENST00000378588.5
cytochrome b-245 beta chain
chr6_-_116126120 0.04 ENST00000452729.1
ENST00000651968.1
ENST00000243222.8
collagen type X alpha 1 chain
chr8_-_42501224 0.04 ENST00000520262.6
ENST00000517366.1
solute carrier family 20 member 2
chr1_-_193106048 0.04 ENST00000367440.3
glutaredoxin 2
chr5_+_148202771 0.04 ENST00000514389.5
ENST00000621437.4
serine peptidase inhibitor Kazal type 6
chr9_+_84669707 0.04 ENST00000277120.8
ENST00000323115.10
neurotrophic receptor tyrosine kinase 2
chr1_+_167329044 0.04 ENST00000367862.9
POU class 2 homeobox 1
chr1_+_213987929 0.04 ENST00000498508.6
ENST00000366958.9
prospero homeobox 1
chr11_+_22666604 0.03 ENST00000454584.6
growth arrest specific 2
chr6_+_151690492 0.03 ENST00000404742.5
ENST00000440973.5
estrogen receptor 1
chr6_-_31546552 0.03 ENST00000303892.10
ENST00000376151.4
ATPase H+ transporting V1 subunit G2
chr11_+_92224801 0.03 ENST00000525166.6
FAT atypical cadherin 3
chr14_+_36661852 0.03 ENST00000361487.7
paired box 9
chr8_-_66178455 0.03 ENST00000276571.5
corticotropin releasing hormone
chr11_-_16356538 0.03 ENST00000683767.1
SRY-box transcription factor 6
chr2_+_176151543 0.03 ENST00000306324.4
homeobox D4
chr5_+_66958870 0.03 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr18_+_3247778 0.02 ENST00000217652.8
ENST00000578611.5
ENST00000583449.1
myosin light chain 12A
chr15_+_80059568 0.02 ENST00000613266.4
ENST00000561060.5
zinc finger AN1-type containing 6
chr9_+_92964272 0.02 ENST00000468206.6
FYVE, RhoGEF and PH domain containing 3
chr20_+_54475584 0.02 ENST00000262593.10
docking protein 5
chrX_-_120311452 0.02 ENST00000371369.9
transmembrane protein 255A
chrX_-_120311408 0.02 ENST00000309720.9
transmembrane protein 255A
chr15_+_80059635 0.02 ENST00000559157.5
zinc finger AN1-type containing 6
chr1_+_158461574 0.02 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
olfactory receptor family 10 subfamily K member 1
chr19_+_44905785 0.02 ENST00000446996.5
ENST00000252486.9
ENST00000434152.5
apolipoprotein E
chr12_-_86256299 0.02 ENST00000552808.6
ENST00000547225.5
MGAT4 family member C
chr3_-_57199938 0.02 ENST00000473921.2
ENST00000295934.8
HESX homeobox 1
chr12_+_53454718 0.02 ENST00000552819.5
ENST00000455667.7
poly(rC) binding protein 2
chr12_-_23951020 0.02 ENST00000441133.2
ENST00000545921.5
SRY-box transcription factor 5
chr1_-_113871665 0.02 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
protein tyrosine phosphatase non-receptor type 22
chr10_-_99930893 0.02 ENST00000636706.1
dynamin binding protein
chrX_-_120311533 0.02 ENST00000440464.5
ENST00000519908.1
transmembrane protein 255A
chr13_-_52848632 0.02 ENST00000377942.7
ENST00000338862.5
protocadherin 8
chr17_+_44957907 0.01 ENST00000678938.1
N-myristoyltransferase 1
chr3_+_121593363 0.01 ENST00000338040.6
F-box protein 40
chr12_-_10939263 0.01 ENST00000537503.2
taste 2 receptor member 14
chr10_+_11005301 0.01 ENST00000416382.6
ENST00000631460.1
ENST00000631816.1
CUGBP Elav-like family member 2
chr15_+_90201301 0.01 ENST00000411539.6
semaphorin 4B
chr3_+_69084973 0.01 ENST00000478935.1
ADP ribosylation factor like GTPase 6 interacting protein 5
chr17_-_50707855 0.01 ENST00000285243.7
ankyrin repeat domain 40
chr14_-_37595224 0.01 ENST00000250448.5
forkhead box A1
chr2_+_170715317 0.01 ENST00000375281.4
Sp5 transcription factor
chr2_-_43226594 0.01 ENST00000282388.4
ZFP36 ring finger protein like 2
chr1_-_156490599 0.01 ENST00000360595.7
myocyte enhancer factor 2D
chr15_+_80059651 0.01 ENST00000561012.5
ENST00000261749.11
ENST00000564367.5
ENST00000558494.5
zinc finger AN1-type containing 6
chr16_+_7332744 0.01 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RNA binding fox-1 homolog 1
chr8_+_76681208 0.01 ENST00000651372.2
zinc finger homeobox 4
chr10_+_116545907 0.01 ENST00000369221.2
pancreatic lipase
chr4_+_15427998 0.01 ENST00000444304.3
C1q and TNF related 7
chr2_+_167187364 0.00 ENST00000672671.1
xin actin binding repeat containing 2
chr12_+_53454764 0.00 ENST00000439930.7
ENST00000548933.5
poly(rC) binding protein 2
chr12_+_71664352 0.00 ENST00000547843.1
THAP domain containing 2
chr5_-_146182475 0.00 ENST00000674158.1
ENST00000674191.1
ENST00000274562.13
leucyl-tRNA synthetase 1
chr4_-_151226427 0.00 ENST00000304527.8
ENST00000409598.8
SH3 domain containing 19
chr17_+_39738317 0.00 ENST00000394211.7
growth factor receptor bound protein 7
chr5_-_146182591 0.00 ENST00000510191.5
ENST00000674277.1
ENST00000674447.1
ENST00000674270.1
ENST00000394434.7
ENST00000674290.1
ENST00000674398.1
ENST00000674174.1
leucyl-tRNA synthetase 1
chr11_-_13495984 0.00 ENST00000282091.6
parathyroid hormone
chr12_+_53454819 0.00 ENST00000562264.5
poly(rC) binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016121 tetraterpenoid metabolic process(GO:0016108) carotenoid metabolic process(GO:0016116) carotene catabolic process(GO:0016121) xanthophyll metabolic process(GO:0016122) terpene catabolic process(GO:0046247)
0.1 0.3 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.1 0.3 GO:0002086 diaphragm contraction(GO:0002086)
0.1 0.2 GO:0097274 ammonia homeostasis(GO:0097272) urea homeostasis(GO:0097274)
0.1 0.4 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.4 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926) positive regulation of hair follicle development(GO:0051798)
0.0 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.0 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.1 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 0.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.0 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.6 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism