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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXB13

Z-value: 0.25

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Transcription factors associated with HOXB13

Gene Symbol Gene ID Gene Info
HOXB13
ENSG00000159184.8 HOXB13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB13hg38_v1_chr17_-_48728705_48728756-0.067.6e-01Click!

Activity profile of HOXB13 motif

Sorted Z-values of HOXB13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB13

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_122371036 0.64 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371014 0.57 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr2_-_189179754 0.56 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr11_-_102955705 0.52 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
MMP13
matrix metallopeptidase 13
chr17_-_41382298 0.44 ENST00000394001.3
KRT34
keratin 34
chr5_+_136160986 0.39 ENST00000507637.1
SMAD5
SMAD family member 5
chr1_-_45491150 0.26 ENST00000372086.4
TESK2
testis associated actin remodelling kinase 2
chr6_+_122471913 0.25 ENST00000615438.4
ENST00000392491.6
PKIB
cAMP-dependent protein kinase inhibitor beta
chr21_-_30829755 0.21 ENST00000621162.1
KRTAP7-1
keratin associated protein 7-1
chr19_+_55643592 0.18 ENST00000270451.6
ENST00000588537.1
ZNF581
zinc finger protein 581
chr17_-_75667088 0.17 ENST00000578201.5
ENST00000423245.6
ENST00000317905.10
RECQL5
RecQ like helicase 5
chr1_+_110451132 0.17 ENST00000271331.4
PROK1
prokineticin 1
chr5_-_145835285 0.16 ENST00000505416.5
ENST00000334744.8
ENST00000511435.1
PRELID2
PRELI domain containing 2
chr1_-_155910881 0.14 ENST00000609492.1
ENST00000368322.7
RIT1
Ras like without CAAX 1
chr9_+_122370523 0.14 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr5_-_145835330 0.13 ENST00000394450.6
ENST00000683046.1
PRELID2
PRELI domain containing 2
chrM_-_14669 0.13 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr6_-_27814757 0.12 ENST00000333151.5
H2AC14
H2A clustered histone 14
chr1_+_84164684 0.12 ENST00000370680.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr6_-_43053832 0.12 ENST00000265348.9
ENST00000674134.1
ENST00000674100.1
CUL7
cullin 7
chr11_+_118530990 0.11 ENST00000411589.6
ENST00000359862.8
ENST00000442938.6
TMEM25
transmembrane protein 25
chr12_-_81598360 0.11 ENST00000333447.11
ENST00000407050.8
PPFIA2
PTPRF interacting protein alpha 2
chr7_+_133253064 0.10 ENST00000393161.6
ENST00000253861.5
EXOC4
exocyst complex component 4
chr1_+_84164962 0.10 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_-_216013517 0.10 ENST00000263268.11
MREG
melanoregulin
chr12_-_52321395 0.10 ENST00000293670.3
KRT83
keratin 83
chr1_-_149812359 0.09 ENST00000369167.2
ENST00000545683.1
H2BC18
H2B clustered histone 18
chr6_+_26224192 0.08 ENST00000634733.1
H3C6
H3 clustered histone 6
chr8_+_96584920 0.08 ENST00000521590.5
SDC2
syndecan 2
chr9_-_14180779 0.08 ENST00000380924.1
ENST00000543693.5
NFIB
nuclear factor I B
chr1_+_84164370 0.07 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr2_+_172860038 0.07 ENST00000538974.5
ENST00000540783.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr17_+_18183803 0.07 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr1_+_210328244 0.07 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr17_-_10657302 0.07 ENST00000583535.6
MYH3
myosin heavy chain 3
chr9_+_73151833 0.06 ENST00000456643.5
ENST00000257497.11
ENST00000415424.5
ANXA1
annexin A1
chr12_-_81598332 0.05 ENST00000443686.7
PPFIA2
PTPRF interacting protein alpha 2
chr12_+_8157034 0.05 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr19_+_35143237 0.05 ENST00000586063.5
ENST00000270310.7
ENST00000588265.1
FXYD7
FXYD domain containing ion transport regulator 7
chr12_+_69825221 0.05 ENST00000552032.7
MYRFL
myelin regulatory factor like
chr3_-_15798184 0.05 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chrX_+_116170742 0.05 ENST00000371906.5
ENST00000681852.1
AGTR2
angiotensin II receptor type 2
chr6_-_139291987 0.04 ENST00000358430.8
TXLNB
taxilin beta
chr3_+_68004231 0.04 ENST00000478136.6
TAFA1
TAFA chemokine like family member 1
chr4_-_68245683 0.04 ENST00000332644.6
TMPRSS11B
transmembrane serine protease 11B
chr3_-_115071333 0.04 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr19_-_5903703 0.03 ENST00000586349.5
ENST00000585661.1
ENST00000592634.5
ENST00000418389.6
ENST00000308961.5
ENSG00000267740.5
NDUFA11
novel protein
NADH:ubiquinone oxidoreductase subunit A11
chr4_-_163613505 0.03 ENST00000339875.9
MARCHF1
membrane associated ring-CH-type finger 1
chr16_-_71577082 0.03 ENST00000355962.5
TAT
tyrosine aminotransferase
chr17_+_18183052 0.03 ENST00000541285.1
ALKBH5
alkB homolog 5, RNA demethylase
chr16_+_2155698 0.03 ENST00000565383.5
ENST00000326181.11
ENST00000567653.5
TRAF7
TNF receptor associated factor 7
chr11_+_118531183 0.03 ENST00000528373.5
ENST00000313236.10
ENST00000354284.8
ENST00000533137.5
ENST00000532762.5
ENST00000526973.5
ENST00000354064.11
ENST00000533102.5
ENST00000527267.1
ENST00000524725.5
ENST00000533689.1
TMEM25
transmembrane protein 25
chr5_-_127073467 0.03 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
C5orf63
chromosome 5 open reading frame 63
chr7_+_16661182 0.03 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr20_+_58907981 0.03 ENST00000656419.1
GNAS
GNAS complex locus
chr6_+_27815010 0.03 ENST00000621112.2
H2BC14
H2B clustered histone 14
chr3_-_15797930 0.03 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr12_+_69825273 0.02 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr17_-_75667165 0.02 ENST00000584999.1
ENST00000420326.6
ENST00000340830.9
RECQL5
RecQ like helicase 5
chr15_-_55249029 0.02 ENST00000566877.5
RAB27A
RAB27A, member RAS oncogene family
chr11_+_63838902 0.02 ENST00000377810.8
MARK2
microtubule affinity regulating kinase 2
chr2_-_24328113 0.02 ENST00000622089.4
ITSN2
intersectin 2
chr8_+_76681208 0.01 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr1_+_65992389 0.01 ENST00000423207.6
PDE4B
phosphodiesterase 4B
chr2_+_74458400 0.01 ENST00000393972.7
ENST00000233615.7
ENST00000409737.5
ENST00000428943.1
WBP1
WW domain binding protein 1
chr16_-_24931090 0.01 ENST00000571843.1
ARHGAP17
Rho GTPase activating protein 17
chr5_-_140673568 0.01 ENST00000542735.2
DND1
DND microRNA-mediated repression inhibitor 1
chr17_-_41489907 0.01 ENST00000328119.11
KRT36
keratin 36
chr2_-_174764436 0.00 ENST00000409323.1
ENST00000261007.9
ENST00000348749.9
ENST00000672640.1
CHRNA1
cholinergic receptor nicotinic alpha 1 subunit
chr7_+_18496269 0.00 ENST00000432645.6
HDAC9
histone deacetylase 9
chr3_-_123991352 0.00 ENST00000184183.8
ROPN1
rhophilin associated tail protein 1
chr2_-_51032091 0.00 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr14_-_50561119 0.00 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr16_-_24930952 0.00 ENST00000571406.1
ARHGAP17
Rho GTPase activating protein 17

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.4 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 1.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.5 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.0 GO:0032304 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) negative regulation of icosanoid secretion(GO:0032304)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0048341 paraxial mesoderm formation(GO:0048341)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.4 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix