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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for HOXB5

Z-value: 0.63

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Transcription factors associated with HOXB5

Gene Symbol Gene ID Gene Info
HOXB5
ENSG00000120075.6 HOXB5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB5hg38_v1_chr17_-_48593748_485937860.242.1e-01Click!

Activity profile of HOXB5 motif

Sorted Z-values of HOXB5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_132085655 4.94 ENST00000262283.5
ENSG00000258417.3
novel protein
chr19_-_15934410 1.28 ENST00000326742.12
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chr19_-_15934521 1.15 ENST00000402119.9
CYP4F11
cytochrome P450 family 4 subfamily F member 11
chrX_+_136148440 1.13 ENST00000627383.2
ENST00000630084.2
FHL1
four and a half LIM domains 1
chr1_-_16978276 1.08 ENST00000375534.7
MFAP2
microfibril associated protein 2
chr19_-_49640092 0.94 ENST00000246792.4
RRAS
RAS related
chr12_+_56521990 0.83 ENST00000550726.5
ENST00000542360.1
RBMS2
RNA binding motif single stranded interacting protein 2
chr12_+_56521951 0.83 ENST00000552247.6
RBMS2
RNA binding motif single stranded interacting protein 2
chr15_-_74725370 0.82 ENST00000567032.5
ENST00000564596.5
ENST00000566503.1
ENST00000395049.8
ENST00000379727.8
ENST00000617691.4
ENST00000395048.6
CYP1A1
cytochrome P450 family 1 subfamily A member 1
chr16_-_84618041 0.77 ENST00000564057.1
COTL1
coactosin like F-actin binding protein 1
chr16_-_84618067 0.77 ENST00000262428.5
COTL1
coactosin like F-actin binding protein 1
chr11_-_125778818 0.76 ENST00000358524.8
PATE2
prostate and testis expressed 2
chr17_+_48892761 0.74 ENST00000355938.9
ENST00000393366.7
ENST00000503641.5
ENST00000514808.5
ENST00000506855.1
ATP5MC1
ATP synthase membrane subunit c locus 1
chr11_-_125778788 0.74 ENST00000436890.2
PATE2
prostate and testis expressed 2
chr3_-_195811889 0.68 ENST00000475231.5
MUC4
mucin 4, cell surface associated
chr12_+_56521798 0.62 ENST00000262031.10
RBMS2
RNA binding motif single stranded interacting protein 2
chr10_-_101843765 0.58 ENST00000370046.5
KCNIP2
potassium voltage-gated channel interacting protein 2
chr3_-_195811857 0.56 ENST00000349607.8
ENST00000346145.8
MUC4
mucin 4, cell surface associated
chr3_-_195811916 0.56 ENST00000463781.8
MUC4
mucin 4, cell surface associated
chr18_-_35497591 0.55 ENST00000589273.1
ENST00000586489.5
INO80C
INO80 complex subunit C
chr11_-_128522189 0.53 ENST00000526145.6
ETS1
ETS proto-oncogene 1, transcription factor
chr19_+_49363923 0.49 ENST00000597546.1
DKKL1
dickkopf like acrosomal protein 1
chr1_+_4654732 0.48 ENST00000378190.7
AJAP1
adherens junctions associated protein 1
chr3_-_165196689 0.47 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr11_+_63506046 0.46 ENST00000674247.1
LGALS12
galectin 12
chr7_-_102611591 0.45 ENST00000461209.5
RASA4
RAS p21 protein activator 4
chr1_+_155610218 0.41 ENST00000649846.1
ENST00000245564.8
ENST00000368341.8
MSTO1
misato mitochondrial distribution and morphology regulator 1
chr20_+_8789517 0.40 ENST00000437439.2
PLCB1
phospholipase C beta 1
chrX_+_47218232 0.39 ENST00000457458.6
ENST00000522883.1
CDK16
cyclin dependent kinase 16
chr1_+_157993601 0.39 ENST00000359209.11
KIRREL1
kirre like nephrin family adhesion molecule 1
chr3_+_51385282 0.38 ENST00000528157.7
MANF
mesencephalic astrocyte derived neurotrophic factor
chrX_+_48521817 0.37 ENST00000446158.5
ENST00000414061.1
EBP
EBP cholestenol delta-isomerase
chrX_+_48521788 0.37 ENST00000651615.1
ENST00000495186.6
ENSG00000286268.1
EBP
novel protein
EBP cholestenol delta-isomerase
chr2_+_17541157 0.36 ENST00000406397.1
VSNL1
visinin like 1
chr1_-_161223559 0.36 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr2_+_17540670 0.32 ENST00000451533.5
ENST00000295156.9
VSNL1
visinin like 1
chr2_-_46941710 0.32 ENST00000409207.5
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr1_+_4654601 0.31 ENST00000378191.5
AJAP1
adherens junctions associated protein 1
chr2_-_46941760 0.28 ENST00000444761.6
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
chr7_+_142800957 0.27 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr10_-_101843777 0.26 ENST00000356640.7
KCNIP2
potassium voltage-gated channel interacting protein 2
chr11_-_35418966 0.25 ENST00000531628.2
SLC1A2
solute carrier family 1 member 2
chr11_-_35419098 0.23 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr21_-_44262216 0.20 ENST00000270172.7
DNMT3L
DNA methyltransferase 3 like
chr17_-_17237122 0.20 ENST00000389169.9
ENST00000285071.9
ENST00000417064.1
FLCN
folliculin
chr3_-_127822455 0.20 ENST00000265052.10
MGLL
monoglyceride lipase
chr1_-_247458105 0.20 ENST00000641149.1
ENST00000641527.1
OR2B11
olfactory receptor family 2 subfamily B member 11
chr1_+_146938744 0.19 ENST00000617931.4
NBPF12
NBPF member 12
chr12_-_52321395 0.19 ENST00000293670.3
KRT83
keratin 83
chr12_+_57591158 0.18 ENST00000422156.7
ENST00000354947.10
ENST00000540759.6
ENST00000551772.5
ENST00000550465.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr14_+_22105305 0.17 ENST00000390453.1
TRAV24
T cell receptor alpha variable 24
chr16_-_57971086 0.17 ENST00000564448.5
ENST00000311183.8
CNGB1
cyclic nucleotide gated channel subunit beta 1
chrM_+_12329 0.16 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr17_-_44066595 0.16 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr19_+_49363730 0.15 ENST00000596402.1
ENST00000221498.7
DKKL1
dickkopf like acrosomal protein 1
chr5_+_150190035 0.14 ENST00000230671.7
ENST00000524041.1
SLC6A7
solute carrier family 6 member 7
chr6_-_96837460 0.14 ENST00000229955.4
GPR63
G protein-coupled receptor 63
chr11_+_4643966 0.14 ENST00000396952.6
OR51E1
olfactory receptor family 51 subfamily E member 1
chr14_+_21477177 0.14 ENST00000448790.7
ENST00000673643.1
ENST00000457430.2
ENST00000673911.1
TOX4
TOX high mobility group box family member 4
chr6_+_167111789 0.14 ENST00000400926.5
CCR6
C-C motif chemokine receptor 6
chr2_-_187565751 0.13 ENST00000421427.5
TFPI
tissue factor pathway inhibitor
chr1_-_161223408 0.13 ENST00000491350.1
APOA2
apolipoprotein A2
chr1_-_206023889 0.12 ENST00000358184.7
ENST00000360218.3
ENST00000678712.1
ENST00000678498.1
CTSE
cathepsin E
chr11_+_109422174 0.12 ENST00000327419.7
C11orf87
chromosome 11 open reading frame 87
chr19_+_13151975 0.12 ENST00000588173.1
IER2
immediate early response 2
chr17_+_6776209 0.11 ENST00000321535.5
FBXO39
F-box protein 39
chr11_-_57322197 0.10 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1
chr19_-_49763295 0.09 ENST00000246801.8
TSKS
testis specific serine kinase substrate
chr4_-_151325488 0.08 ENST00000604030.7
SH3D19
SH3 domain containing 19
chr5_-_35047935 0.07 ENST00000510428.1
ENST00000231420.11
AGXT2
alanine--glyoxylate aminotransferase 2
chr3_+_45945019 0.07 ENST00000458629.1
ENST00000457814.1
CXCR6
C-X-C motif chemokine receptor 6
chr7_+_130381092 0.07 ENST00000484324.1
CPA1
carboxypeptidase A1
chr1_-_155688475 0.07 ENST00000405763.7
ENST00000368340.9
ENST00000454523.5
ENST00000368339.9
ENST00000443231.5
ENST00000347088.9
ENST00000361831.9
YY1AP1
YY1 associated protein 1
chr3_+_130894382 0.06 ENST00000509662.5
ENST00000328560.12
ENST00000428331.6
ENST00000359644.7
ENST00000422190.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr8_-_92095627 0.06 ENST00000517919.5
ENST00000617740.4
ENST00000613302.4
ENST00000436581.6
ENST00000614812.4
ENST00000519847.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr7_+_5282935 0.06 ENST00000396872.8
ENST00000444741.5
ENST00000297195.8
ENST00000406453.3
SLC29A4
solute carrier family 29 member 4
chrX_+_14529516 0.05 ENST00000218075.9
GLRA2
glycine receptor alpha 2
chr9_-_127937800 0.04 ENST00000373110.4
ENST00000314392.13
DPM2
dolichyl-phosphate mannosyltransferase subunit 2, regulatory
chr20_-_6054026 0.04 ENST00000378858.5
LRRN4
leucine rich repeat neuronal 4
chr20_-_50691536 0.03 ENST00000327979.8
RIPOR3
RIPOR family member 3
chr7_+_121328991 0.03 ENST00000222462.3
WNT16
Wnt family member 16
chr1_-_155688727 0.03 ENST00000404643.5
ENST00000359205.9
ENST00000407221.5
ENST00000355499.9
YY1AP1
YY1 associated protein 1
chr20_-_49568101 0.03 ENST00000244043.5
PTGIS
prostaglandin I2 synthase
chr12_+_53299682 0.03 ENST00000267103.10
ENST00000548632.5
MYG1
MYG1 exonuclease
chr19_-_12156710 0.02 ENST00000455799.1
ENST00000439556.3
ZNF625
zinc finger protein 625
chr1_-_155688294 0.02 ENST00000311573.9
YY1AP1
YY1 associated protein 1
chr6_-_31541937 0.02 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DDX39B
DExD-box helicase 39B
chr1_+_40691689 0.02 ENST00000427410.6
ENST00000447388.7
ENST00000425457.6
ENST00000453631.5
ENST00000456393.6
NFYC
nuclear transcription factor Y subunit gamma
chr8_+_117135259 0.01 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr16_-_57971121 0.01 ENST00000251102.13
CNGB1
cyclic nucleotide gated channel subunit beta 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.3 0.8 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.2 1.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 0.8 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.7 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.5 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.4 GO:0090427 activation of meiosis(GO:0090427)
0.1 0.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 1.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.2 GO:2000506 negative regulation of energy homeostasis(GO:2000506)
0.0 0.5 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 1.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.4 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.7 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 1.1 GO:0043268 regulation of membrane depolarization(GO:0003254) positive regulation of potassium ion transport(GO:0043268)
0.0 0.4 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.7 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.2 0.7 GO:0047750 C-8 sterol isomerase activity(GO:0000247) cholestenol delta-isomerase activity(GO:0047750)
0.2 0.8 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.5 GO:0030395 lactose binding(GO:0030395)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 2.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.2 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.1 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 3.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification