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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for HOXC8
Z-value: 1.07
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Transcription factors associated with HOXC8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC8 | hg38_v1_chr12_+_54008961_54009005 | 0.29 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_27838034 Show fit | 6.09 |
ENST00000522944.5
|
PDZ binding kinase |
|
| chr20_-_7940444 Show fit | 3.80 |
ENST00000378789.4
|
hydroxyacid oxidase 1 |
|
| chr2_+_157257687 Show fit | 3.66 |
ENST00000259056.5
|
polypeptide N-acetylgalactosaminyltransferase 5 |
|
| chr20_+_3786772 Show fit | 3.48 |
ENST00000344256.10
ENST00000379598.9 |
cell division cycle 25B |
|
| chr6_+_151325665 Show fit | 3.18 |
ENST00000354675.10
|
A-kinase anchoring protein 12 |
|
| chr2_+_89851723 Show fit | 2.95 |
ENST00000429992.2
|
immunoglobulin kappa variable 2D-40 |
|
| chr19_-_42877988 Show fit | 2.89 |
ENST00000597058.1
|
pregnancy specific beta-1-glycoprotein 1 |
|
| chr2_+_233195433 Show fit | 2.88 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase D |
|
| chr1_+_44739825 Show fit | 2.84 |
ENST00000372224.9
|
kinesin family member 2C |
|
| chr12_-_10826358 Show fit | 2.83 |
ENST00000240619.2
|
taste 2 receptor member 10 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 8.4 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.3 | 7.1 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.1 | 6.8 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.4 | 6.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 5.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 5.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.5 | 5.0 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.0 | 4.9 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 4.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 9.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 5.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.3 | 5.0 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.0 | 4.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.4 | 3.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 3.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 3.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 3.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 10.6 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.4 | 6.8 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.3 | 4.9 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 4.9 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 4.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 4.6 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 4.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 4.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.3 | 3.8 | GO:0052852 | (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.4 | 5.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 5.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 3.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.8 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 3.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 7.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 7.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 7.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 6.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 5.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 4.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 3.9 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 3.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |