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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ID4_TCF4_SNAI2
Z-value: 2.62
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Transcription factors associated with ID4_TCF4_SNAI2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ID4 | hg38_v1_chr6_+_19837362_19837381 | 0.92 | 6.8e-13 | Click! |
| SNAI2 | hg38_v1_chr8_-_48921419_48921437 | -0.88 | 1.6e-10 | Click! |
| TCF4 | hg38_v1_chr18_-_55401751_55401762, hg38_v1_chr18_-_55423757_55423841 | 0.88 | 1.6e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ID4_TCF4_SNAI2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.8 | 61.7 | GO:2000768 | positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.5 | 48.8 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.3 | 29.7 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.6 | 23.8 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.3 | 22.3 | GO:0016266 | O-glycan processing(GO:0016266) |
| 2.3 | 20.3 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 5.7 | 17.1 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.6 | 16.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.7 | 16.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 2.0 | 15.8 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 64.7 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 2.9 | 60.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.3 | 37.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.9 | 35.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.7 | 23.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 21.5 | GO:0019866 | organelle inner membrane(GO:0019866) |
| 0.2 | 21.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 18.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.6 | 18.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.2 | 18.1 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 68.9 | GO:0042805 | actinin binding(GO:0042805) |
| 0.9 | 17.6 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.5 | 16.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.2 | 15.7 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.5 | 15.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 15.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 14.9 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 1.5 | 14.7 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 14.2 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.8 | 14.0 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 17.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 17.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 11.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.4 | 7.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 7.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 6.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 6.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 5.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 37.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.8 | 26.6 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 25.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 22.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.0 | 21.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 18.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 17.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 16.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 1.1 | 14.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.8 | 14.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |