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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for IKZF1
Z-value: 1.93
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg38_v1_chr7_+_50304693_50304782 | 0.44 | 1.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_31092447 Show fit | 10.94 |
ENST00000455608.5
|
smoothelin |
|
| chr12_-_57237090 Show fit | 9.93 |
ENST00000556732.1
|
NDUFA4 mitochondrial complex associated like 2 |
|
| chr19_-_50953063 Show fit | 9.51 |
ENST00000391809.6
|
kallikrein related peptidase 5 |
|
| chr19_-_50953093 Show fit | 9.35 |
ENST00000593428.5
|
kallikrein related peptidase 5 |
|
| chr19_-_50968125 Show fit | 9.28 |
ENST00000594641.1
|
kallikrein related peptidase 6 |
|
| chr19_-_50952942 Show fit | 8.78 |
ENST00000594846.1
ENST00000336334.8 |
kallikrein related peptidase 5 |
|
| chr19_-_42855691 Show fit | 7.27 |
ENST00000401467.6
|
pregnancy specific beta-1-glycoprotein 8 |
|
| chr2_+_95025700 Show fit | 6.98 |
ENST00000309988.9
ENST00000353004.7 ENST00000354078.7 ENST00000349807.3 |
mal, T cell differentiation protein |
|
| chr15_-_89496574 Show fit | 6.89 |
ENST00000268122.9
|
Rh family C glycoprotein |
|
| chr1_+_20589044 Show fit | 6.72 |
ENST00000375071.4
|
cytidine deaminase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 50.4 | GO:0070268 | cornification(GO:0070268) |
| 6.4 | 38.3 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.3 | 29.8 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 1.1 | 21.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.7 | 20.4 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.7 | 18.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.8 | 16.7 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.7 | 16.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 16.0 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.2 | 15.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 57.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 38.7 | GO:0005615 | extracellular space(GO:0005615) |
| 5.5 | 38.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 38.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.5 | 29.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.0 | 23.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 21.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 18.3 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.2 | 18.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 18.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 127.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 43.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 30.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 30.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 28.9 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.4 | 26.4 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 22.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 20.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.0 | 18.9 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 17.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 56.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 54.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 40.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.5 | 30.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 23.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.6 | 22.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 17.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 16.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 16.9 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.3 | 16.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 32.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 24.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 24.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.5 | 20.8 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.5 | 20.0 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.5 | 19.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 18.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.8 | 18.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 18.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 17.0 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |