Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for IRF2_STAT2_IRF8_IRF1
Z-value: 3.09
Motif logo
Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
IRF2
|
ENSG00000168310.11 | IRF2 |
|
STAT2
|
ENSG00000170581.14 | STAT2 |
|
IRF8
|
ENSG00000140968.11 | IRF8 |
|
IRF1
|
ENSG00000125347.15 | IRF1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg38_v1_chr5_-_132490750_132490840 | 0.90 | 1.1e-11 | Click! |
| STAT2 | hg38_v1_chr12_-_56360084_56360146 | 0.69 | 2.4e-05 | Click! |
| IRF8 | hg38_v1_chr16_+_85899121_85899171 | 0.17 | 3.8e-01 | Click! |
| IRF2 | hg38_v1_chr4_-_184474518_184474556 | 0.13 | 4.8e-01 | Click! |
Activity profile of IRF2_STAT2_IRF8_IRF1 motif
Sorted Z-values of IRF2_STAT2_IRF8_IRF1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.7 | 26.0 | GO:0006227 | dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077) |
| 7.3 | 29.1 | GO:0036269 | swimming behavior(GO:0036269) |
| 6.9 | 20.7 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 6.7 | 33.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 5.8 | 17.5 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542) |
| 4.4 | 13.2 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 4.2 | 12.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 4.2 | 20.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 3.5 | 10.4 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 2.8 | 8.4 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 2.7 | 16.3 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 2.4 | 7.1 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 2.3 | 45.8 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 2.2 | 22.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.2 | 33.3 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 2.0 | 8.0 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.9 | 15.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 1.8 | 21.4 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 1.8 | 5.3 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 1.7 | 5.1 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 1.6 | 4.8 | GO:0000964 | mitochondrial RNA 5'-end processing(GO:0000964) rRNA import into mitochondrion(GO:0035928) |
| 1.6 | 7.9 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 1.4 | 4.2 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 1.3 | 1.3 | GO:1903989 | positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 1.3 | 3.9 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
| 1.2 | 12.0 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 1.2 | 4.8 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 1.1 | 13.0 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.0 | 4.0 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 1.0 | 3.0 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.9 | 25.4 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.9 | 4.5 | GO:2000834 | androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836) |
| 0.9 | 3.5 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.9 | 2.6 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.9 | 3.5 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.8 | 5.8 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.8 | 2.4 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.8 | 33.5 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.8 | 3.9 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.7 | 3.7 | GO:0019075 | virus maturation(GO:0019075) |
| 0.7 | 3.0 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.7 | 2.1 | GO:0002589 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) |
| 0.7 | 2.8 | GO:1904977 | lymphatic endothelial cell migration(GO:1904977) |
| 0.7 | 4.1 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.7 | 2.7 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.7 | 2.0 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.7 | 2.6 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.6 | 7.6 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.6 | 3.2 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.5 | 6.6 | GO:0071073 | positive regulation of phospholipid biosynthetic process(GO:0071073) |
| 0.5 | 2.0 | GO:0034241 | macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) |
| 0.5 | 10.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.5 | 2.3 | GO:0031296 | B cell costimulation(GO:0031296) |
| 0.5 | 9.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.5 | 2.3 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.4 | 3.1 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.4 | 40.6 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.4 | 1.3 | GO:1900238 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591) |
| 0.4 | 2.1 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.4 | 2.4 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.4 | 1.1 | GO:0010607 | negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607) |
| 0.4 | 2.6 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.4 | 2.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.4 | 1.8 | GO:0003051 | angiotensin-mediated drinking behavior(GO:0003051) |
| 0.4 | 8.3 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.3 | 1.0 | GO:1905006 | negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006) |
| 0.3 | 3.4 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.3 | 0.7 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.3 | 2.0 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 0.3 | GO:1904933 | regulation of cell proliferation in midbrain(GO:1904933) |
| 0.3 | 0.6 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.3 | 8.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.3 | 0.9 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.3 | 11.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.3 | 13.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.3 | 2.0 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.3 | 4.8 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.3 | 1.1 | GO:0072695 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.3 | 1.1 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.3 | 4.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 1.3 | GO:0072081 | proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081) specification of loop of Henle identity(GO:0072086) |
| 0.3 | 1.5 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.3 | 1.0 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 0.3 | 0.8 | GO:0070904 | L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.3 | 1.3 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.2 | 1.9 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.2 | 0.5 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.2 | 0.9 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.2 | 0.9 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.2 | 1.8 | GO:1900165 | negative regulation of interleukin-6 secretion(GO:1900165) |
| 0.2 | 0.7 | GO:1902771 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.2 | 4.0 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.2 | 0.6 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.2 | 0.6 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.2 | 3.8 | GO:0006554 | lysine catabolic process(GO:0006554) |
| 0.2 | 4.5 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 1.1 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.2 | 1.3 | GO:0030421 | defecation(GO:0030421) |
| 0.2 | 1.5 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.2 | 0.7 | GO:1903251 | multi-ciliated epithelial cell differentiation(GO:1903251) |
| 0.2 | 0.7 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.2 | 0.7 | GO:1903750 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.2 | 0.9 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.2 | 7.0 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.2 | 1.2 | GO:0001705 | ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712) |
| 0.2 | 2.1 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.2 | 1.6 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.2 | 1.9 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.2 | 0.9 | GO:0034128 | detection of lipopolysaccharide(GO:0032497) negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.2 | 1.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 0.5 | GO:0046968 | peptide antigen transport(GO:0046968) |
| 0.2 | 1.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.6 | GO:0039516 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.2 | 2.5 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.2 | 1.1 | GO:0042078 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.2 | 2.3 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.2 | 3.1 | GO:0032608 | interferon-beta production(GO:0032608) |
| 0.1 | 1.0 | GO:0045627 | positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.1 | 0.9 | GO:0045348 | positive regulation of MHC class II biosynthetic process(GO:0045348) |
| 0.1 | 0.7 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 1.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 0.5 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
| 0.1 | 1.2 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.1 | 0.4 | GO:0090031 | regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) positive regulation of steroid hormone biosynthetic process(GO:0090031) |
| 0.1 | 0.5 | GO:0048690 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 0.1 | 1.1 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 0.1 | 1.0 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 1.9 | GO:0010909 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.1 | 1.2 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 0.5 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.1 | 0.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 0.6 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.1 | 2.0 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.6 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.1 | 21.6 | GO:0007286 | spermatid development(GO:0007286) |
| 0.1 | 0.9 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
| 0.1 | 4.7 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 0.2 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.1 | 0.5 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.1 | 2.5 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.1 | 4.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 2.9 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.7 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.1 | 1.2 | GO:0010623 | programmed cell death involved in cell development(GO:0010623) |
| 0.1 | 1.6 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 1.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.4 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.1 | 2.3 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.1 | 1.3 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.5 | GO:0061741 | vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.1 | 3.2 | GO:0002360 | T cell lineage commitment(GO:0002360) |
| 0.1 | 0.2 | GO:0072161 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.1 | 0.3 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) |
| 0.1 | 0.5 | GO:0006850 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.1 | 0.6 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.3 | GO:2000354 | regulation of ovarian follicle development(GO:2000354) |
| 0.1 | 0.4 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
| 0.1 | 0.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) olfactory nerve development(GO:0021553) |
| 0.1 | 0.4 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.1 | 0.3 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.1 | 0.5 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 0.4 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 3.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.8 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 1.0 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.1 | 0.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 0.5 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.1 | 0.6 | GO:0021678 | third ventricle development(GO:0021678) |
| 0.1 | 0.3 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 0.6 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
| 0.1 | 0.7 | GO:0070543 | toll-like receptor TLR6:TLR2 signaling pathway(GO:0038124) lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) response to linoleic acid(GO:0070543) response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 0.4 | GO:0090027 | negative regulation of monocyte chemotaxis(GO:0090027) |
| 0.1 | 0.8 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.1 | 0.2 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 0.5 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.1 | 1.0 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.1 | 3.9 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.1 | 0.6 | GO:0051597 | response to methylmercury(GO:0051597) |
| 0.1 | 0.2 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) |
| 0.1 | 0.2 | GO:0061114 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.1 | 0.3 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 0.1 | 2.3 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.1 | 0.2 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.1 | 1.2 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 1.3 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.1 | 0.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.1 | 0.6 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 1.3 | GO:1900115 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.1 | 0.8 | GO:0036309 | protein localization to M-band(GO:0036309) |
| 0.1 | 0.2 | GO:0046005 | positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005) |
| 0.1 | 1.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 0.2 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
| 0.1 | 0.4 | GO:0006154 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.1 | 0.5 | GO:0002254 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) |
| 0.1 | 0.5 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 3.1 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 0.5 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.1 | 1.5 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.1 | 3.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 0.9 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.1 | 3.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.1 | 2.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 0.2 | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 0.1 | 0.9 | GO:0021794 | thalamus development(GO:0021794) |
| 0.1 | 0.3 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.1 | 0.3 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.5 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 1.0 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.1 | 0.8 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 0.3 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 0.6 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.1 | 2.5 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.1 | 0.9 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.0 | 0.2 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.8 | GO:1900038 | negative regulation of cellular response to hypoxia(GO:1900038) |
| 0.0 | 0.4 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 1.2 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.5 | GO:0015747 | urate transport(GO:0015747) |
| 0.0 | 2.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.6 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.8 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.0 | 1.7 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.3 | GO:0036018 | cellular response to erythropoietin(GO:0036018) |
| 0.0 | 0.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 0.7 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.6 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.6 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.0 | 3.3 | GO:0009988 | cell-cell recognition(GO:0009988) |
| 0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.0 | 0.0 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.0 | 0.8 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.6 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.0 | 1.7 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.0 | 0.5 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 0.0 | 1.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.5 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.0 | 0.5 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 1.1 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.9 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 2.3 | GO:0045840 | positive regulation of mitotic nuclear division(GO:0045840) |
| 0.0 | 0.8 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 0.2 | GO:1990592 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.0 | 0.8 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.1 | GO:1900163 | regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
| 0.0 | 0.8 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.1 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.0 | 1.1 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.7 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 0.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.0 | 0.5 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.2 | GO:0032962 | positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) |
| 0.0 | 0.5 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.0 | 0.1 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.2 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.0 | 0.3 | GO:0010991 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.3 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.0 | 0.2 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.0 | 0.3 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 1.5 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.5 | GO:2000772 | regulation of cellular senescence(GO:2000772) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 0.2 | GO:0003360 | brainstem development(GO:0003360) |
| 0.0 | 0.1 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 0.1 | GO:0071351 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
| 0.0 | 0.1 | GO:0032489 | regulation of Cdc42 protein signal transduction(GO:0032489) |
| 0.0 | 0.3 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 4.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0050955 | thermoception(GO:0050955) |
| 0.0 | 0.2 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway(GO:0035791) |
| 0.0 | 0.2 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.5 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.4 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
| 0.0 | 0.2 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.0 | 0.2 | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process(GO:0002087) |
| 0.0 | 0.3 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 0.2 | GO:0002775 | antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) |
| 0.0 | 0.8 | GO:0032210 | regulation of telomere maintenance via telomerase(GO:0032210) |
| 0.0 | 0.3 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.0 | 0.1 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.1 | GO:1903352 | L-ornithine transmembrane transport(GO:1903352) |
| 0.0 | 0.3 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.3 | GO:0006744 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.0 | 0.5 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.0 | 0.1 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.0 | 0.1 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 0.1 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
| 0.0 | 0.1 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.0 | 0.2 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.0 | 0.1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.2 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 0.6 | GO:0030317 | sperm motility(GO:0030317) |
| 0.0 | 0.4 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.0 | 0.1 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.0 | 0.1 | GO:0032026 | response to magnesium ion(GO:0032026) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 29.1 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 4.5 | 36.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.6 | 11.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.9 | 6.1 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.8 | 2.4 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.6 | 7.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.6 | 2.6 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.5 | 0.5 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.4 | 4.8 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.4 | 6.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.4 | 34.3 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.3 | 4.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 2.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.3 | 2.9 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.3 | 1.3 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.3 | 3.4 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 4.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.2 | 4.8 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.2 | 3.7 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.2 | 4.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.3 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.2 | 0.8 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.2 | 12.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 2.5 | GO:0032009 | early phagosome(GO:0032009) |
| 0.2 | 12.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.2 | 1.9 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 1.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.2 | 1.5 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 18.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 3.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 1.1 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 11.5 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 16.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 0.7 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 1.5 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 0.5 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 0.3 | GO:0034455 | t-UTP complex(GO:0034455) |
| 0.1 | 6.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 1.6 | GO:0098553 | integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.1 | 1.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 22.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 2.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 37.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 0.8 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.1 | 0.4 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 6.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.7 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 0.2 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.1 | 16.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 0.6 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 0.1 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.1 | 4.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 1.1 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 0.7 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 3.8 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.7 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 10.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 1.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 2.3 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 0.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 0.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 1.0 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 0.2 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.0 | 0.5 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 108.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 0.1 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.0 | 1.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.4 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 1.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 0.5 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 2.5 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 6.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.2 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 0.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 1.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.8 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.5 | GO:0036019 | endolysosome(GO:0036019) |
| 0.0 | 0.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 1.2 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.2 | GO:0016011 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.0 | 0.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.7 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 0.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 1.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 22.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.5 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.2 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 1.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 12.5 | GO:0044431 | Golgi apparatus part(GO:0044431) |
| 0.0 | 0.1 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.0 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 0.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 29.1 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 8.7 | 26.0 | GO:0004798 | thymidylate kinase activity(GO:0004798) |
| 4.4 | 17.5 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 3.5 | 10.4 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 2.6 | 20.7 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 2.1 | 6.2 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 1.6 | 9.5 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 1.5 | 12.2 | GO:0046979 | TAP2 binding(GO:0046979) |
| 1.3 | 37.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.1 | 4.4 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.9 | 6.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.9 | 4.5 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.9 | 5.3 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.9 | 2.6 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.9 | 6.0 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.8 | 3.1 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.7 | 10.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.7 | 2.1 | GO:0016497 | substance K receptor activity(GO:0016497) |
| 0.7 | 2.0 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 0.6 | 4.5 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.6 | 3.5 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.6 | 15.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.5 | 7.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.5 | 2.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.5 | 2.0 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.5 | 12.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.5 | 0.5 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.5 | 1.4 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.4 | 8.4 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.4 | 2.6 | GO:0005497 | androgen binding(GO:0005497) benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.4 | 64.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.4 | 3.0 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.4 | 5.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.4 | 1.8 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.4 | 3.9 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.3 | 3.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.3 | 1.3 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.3 | 6.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 1.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.3 | 1.3 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.3 | 0.9 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.3 | 7.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 6.8 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.3 | 1.1 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.3 | 1.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 1.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.3 | 3.9 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.3 | 14.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.3 | 0.8 | GO:0008520 | L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.2 | 7.8 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.2 | 0.7 | GO:0031780 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
| 0.2 | 3.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 9.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 8.9 | GO:0001848 | complement binding(GO:0001848) |
| 0.2 | 1.9 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 0.9 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.2 | 3.9 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.2 | 4.5 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.2 | 2.5 | GO:0019864 | IgG binding(GO:0019864) |
| 0.2 | 0.7 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.2 | 1.5 | GO:0102344 | 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345) |
| 0.2 | 8.4 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.2 | 1.3 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.2 | 3.6 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.2 | 0.6 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.2 | 1.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.2 | 2.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.2 | 1.1 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.2 | 0.6 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.2 | 1.5 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.2 | 0.2 | GO:1904713 | beta-catenin destruction complex binding(GO:1904713) |
| 0.2 | 4.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 3.7 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.2 | 2.4 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 0.2 | 1.0 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 0.5 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.2 | 6.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 4.8 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 0.5 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 0.2 | 0.5 | GO:0008441 | 3'(2'),5'-bisphosphate nucleotidase activity(GO:0008441) |
| 0.1 | 78.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 2.6 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 1.6 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.1 | 0.6 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.1 | 1.2 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.1 | 3.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.5 | GO:0051500 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.1 | 0.6 | GO:0015094 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 1.0 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 5.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.8 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 18.1 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.1 | 1.5 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.5 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 0.5 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.1 | 0.3 | GO:0072590 | N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) |
| 0.1 | 1.0 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 0.3 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 0.1 | 0.9 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 0.7 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.1 | 0.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 0.2 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.1 | 1.1 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 0.2 | GO:0071566 | UFM1 activating enzyme activity(GO:0071566) |
| 0.1 | 0.5 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.1 | 0.5 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.1 | 0.4 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) |
| 0.1 | 0.6 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 1.1 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 1.1 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 0.3 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 1.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 6.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 0.3 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.1 | 0.4 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.1 | 0.2 | GO:0016608 | growth hormone-releasing hormone activity(GO:0016608) |
| 0.1 | 1.1 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 1.0 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.1 | 0.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 2.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.5 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 7.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 0.2 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.1 | 1.0 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 1.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 4.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 1.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 0.9 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 0.4 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 0.4 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.0 | 0.2 | GO:0031726 | receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 2.3 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.9 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.0 | 0.3 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 1.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.6 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.0 | 0.2 | GO:1990763 | arrestin family protein binding(GO:1990763) |
| 0.0 | 0.1 | GO:0042008 | interleukin-18 receptor activity(GO:0042008) |
| 0.0 | 0.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.0 | 0.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 1.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 6.7 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.1 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 0.0 | 0.2 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.2 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.0 | 0.7 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.0 | 1.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.5 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 2.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 12.0 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 1.2 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 0.5 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.0 | 11.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.2 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.1 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.0 | 1.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.0 | 3.3 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 0.8 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.2 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.0 | 1.0 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.0 | 0.3 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.9 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.5 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 2.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 4.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 2.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.8 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.6 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.1 | GO:0052857 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.0 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.1 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.0 | 1.6 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 1.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.1 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.0 | 0.7 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.0 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 1.4 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 0.2 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 0.6 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.0 | 0.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.5 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.5 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 0.0 | 1.4 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 0.5 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.0 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 0.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.3 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 4.7 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 1.9 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 10.1 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.1 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.4 | GO:0070840 | dynein complex binding(GO:0070840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 17.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 10.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 1.2 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 2.6 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 14.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 14.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 15.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 9.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 9.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.3 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 2.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 3.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 2.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 1.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 0.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 2.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 1.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 4.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.2 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.6 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.4 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.3 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 32.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 2.0 | 9.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.5 | 19.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 1.5 | 164.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.2 | 20.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.7 | 7.7 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.6 | 10.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.5 | 10.4 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.5 | 36.7 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.5 | 9.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.4 | 17.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 3.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.3 | 0.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 2.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.2 | 2.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 1.9 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.2 | 4.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 7.0 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 6.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 6.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 1.3 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 0.3 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.1 | 1.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.3 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 0.8 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 2.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 3.1 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 2.0 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 1.5 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 0.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 1.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 3.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 1.1 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.9 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 1.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 3.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 2.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.3 | REACTOME KERATAN SULFATE KERATIN METABOLISM | Genes involved in Keratan sulfate/keratin metabolism |
| 0.0 | 0.4 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.4 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 3.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.2 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |