Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for IRF3
Z-value: 1.19
Motif logo
Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg38_v1_chr19_-_49665603_49665617 | 0.22 | 2.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 10.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.5 | 7.7 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 2.5 | 7.4 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542) |
| 0.3 | 7.2 | GO:0070233 | negative regulation of T cell apoptotic process(GO:0070233) |
| 0.6 | 6.7 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 1.3 | 6.3 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.2 | 6.0 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.1 | 6.0 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 1.1 | 4.5 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.4 | 4.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 6.0 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 5.9 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.8 | 4.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 3.9 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 3.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 3.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.4 | 3.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 2.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.7 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 1.9 | 7.4 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.4 | 6.4 | GO:0019864 | IgG binding(GO:0019864) |
| 1.5 | 4.5 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.0 | 3.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 3.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 3.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.2 | 2.8 | GO:0031386 | protein tag(GO:0031386) |
| 0.7 | 2.1 | GO:0004798 | thymidylate kinase activity(GO:0004798) |
| 0.4 | 2.1 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 5.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 2.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 1.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 1.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 7.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 6.1 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.1 | 4.6 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.4 | 4.5 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 3.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 1.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |