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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for IRX6_IRX4

Z-value: 0.20

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.8 IRX6
IRX4
ENSG00000113430.10 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg38_v1_chr5_-_1882902_1882932,
hg38_v1_chr5_-_1886938_1886984		-0.154.3e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_+_36608146 0.37 ENST00000381918.4
ENST00000513646.1
SLC1A3
solute carrier family 1 member 3
chr1_+_63523490 0.31 ENST00000371088.5
EFCAB7
EF-hand calcium binding domain 7
chr12_-_10130241 0.25 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chr3_-_9952337 0.25 ENST00000411976.2
ENST00000412055.6
PRRT3
proline rich transmembrane protein 3
chr1_+_61081728 0.23 ENST00000371189.8
NFIA
nuclear factor I A
chr12_-_10130143 0.22 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr1_+_61082398 0.20 ENST00000664149.1
NFIA
nuclear factor I A
chr5_+_93583212 0.20 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr17_-_49646581 0.19 ENST00000510476.5
ENST00000503676.5
SPOP
speckle type BTB/POZ protein
chr12_-_10130082 0.19 ENST00000533022.5
CLEC7A
C-type lectin domain containing 7A
chr7_-_16804987 0.19 ENST00000401412.5
ENST00000419304.7
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr6_+_116369837 0.17 ENST00000645988.1
DSE
dermatan sulfate epimerase
chr6_-_52840843 0.16 ENST00000370989.6
GSTA5
glutathione S-transferase alpha 5
chr4_+_41359599 0.16 ENST00000513024.5
LIMCH1
LIM and calponin homology domains 1
chr8_+_67064316 0.16 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
CSPP1
centrosome and spindle pole associated protein 1
chr21_-_32813679 0.15 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr19_-_54463762 0.15 ENST00000611161.2
LENG9
leukocyte receptor cluster member 9
chr16_+_726936 0.14 ENST00000549114.5
ENST00000341413.8
ENST00000562187.1
ENST00000564537.5
ENST00000389703.8
HAGHL
hydroxyacylglutathione hydrolase like
chr16_+_727246 0.14 ENST00000561546.5
ENST00000564545.1
ENST00000567414.5
ENST00000568141.5
HAGHL
hydroxyacylglutathione hydrolase like
chr6_-_33711684 0.13 ENST00000374231.8
ENST00000607484.6
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr8_-_17697654 0.12 ENST00000297488.10
MTUS1
microtubule associated scaffold protein 1
chr20_+_56358938 0.11 ENST00000371384.4
ENST00000437418.1
FAM210B
family with sequence similarity 210 member B
chr1_-_38881587 0.11 ENST00000357771.5
ENST00000621281.1
GJA9
ENSG00000274944.4
gap junction protein alpha 9
novel protein
chr20_+_45361936 0.09 ENST00000372727.5
ENST00000414310.5
SYS1
SYS1 golgi trafficking protein
chr1_+_170935526 0.09 ENST00000367758.7
ENST00000367759.9
MROH9
maestro heat like repeat family member 9
chr6_-_33711717 0.08 ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chrX_+_22136552 0.08 ENST00000682888.1
ENST00000684356.1
PHEX
phosphate regulating endopeptidase homolog X-linked
chr14_-_23154422 0.08 ENST00000422941.6
SLC7A8
solute carrier family 7 member 8
chr20_+_10218808 0.08 ENST00000254976.7
ENST00000304886.6
SNAP25
synaptosome associated protein 25
chr3_+_171843337 0.07 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chr7_-_93226449 0.07 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr9_-_41189310 0.07 ENST00000456520.5
ENST00000377391.8
ENST00000613716.4
ENST00000617933.1
CBWD6
COBW domain containing 6
chr19_+_50188180 0.07 ENST00000598205.5
MYH14
myosin heavy chain 14
chr9_-_37465402 0.06 ENST00000307750.5
ZBTB5
zinc finger and BTB domain containing 5
chr15_+_66293541 0.06 ENST00000319212.9
ENST00000525109.1
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chr15_+_66293217 0.05 ENST00000319194.9
ENST00000525134.6
DIS3L
DIS3 like exosome 3'-5' exoribonuclease
chr11_+_60280577 0.05 ENST00000679988.1
MS4A4A
membrane spanning 4-domains A4A
chr9_+_68241854 0.05 ENST00000616550.4
ENST00000618217.4
ENST00000377342.9
ENST00000478048.5
ENST00000360171.11
CBWD3
COBW domain containing 3
chr8_+_232137 0.05 ENST00000521145.5
ENST00000320552.6
ENST00000308811.8
ENST00000640035.1
ENST00000522866.5
ZNF596
zinc finger protein 596
chr11_+_60280531 0.04 ENST00000532114.6
MS4A4A
membrane spanning 4-domains A4A
chr2_-_55917699 0.04 ENST00000634374.1
EFEMP1
EGF containing fibulin extracellular matrix protein 1
chr9_+_65675834 0.04 ENST00000377392.9
ENST00000377384.5
ENST00000430059.6
ENST00000429800.6
ENST00000382405.8
ENST00000377395.8
CBWD5
COBW domain containing 5
chr9_-_27573653 0.04 ENST00000379995.1
ENST00000647196.1
ENST00000619707.5
ENST00000379997.7
C9orf72
C9orf72-SMCR8 complex subunit
chr3_-_169147734 0.04 ENST00000464456.5
MECOM
MDS1 and EVI1 complex locus
chr10_-_114144599 0.04 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr22_+_24270776 0.04 ENST00000437398.5
ENST00000421374.5
ENST00000314328.14
ENST00000651059.1
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1 like
chr5_-_177780633 0.03 ENST00000513554.5
ENST00000440605.7
FAM153A
family with sequence similarity 153 member A
chr14_-_23154369 0.03 ENST00000453702.5
SLC7A8
solute carrier family 7 member 8
chr10_+_116591010 0.03 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr4_+_70592295 0.03 ENST00000449493.2
AMBN
ameloblastin
chr4_+_70592253 0.03 ENST00000322937.10
ENST00000613447.4
AMBN
ameloblastin
chr10_+_116590956 0.03 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr2_+_225399684 0.03 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chrX_-_15315615 0.03 ENST00000380470.7
ENST00000480796.6
ASB11
ankyrin repeat and SOCS box containing 11
chr13_+_111186773 0.03 ENST00000426073.6
ARHGEF7
Rho guanine nucleotide exchange factor 7
chr14_+_55661272 0.02 ENST00000555573.5
KTN1
kinectin 1
chr4_+_112637514 0.02 ENST00000651579.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr4_+_129096144 0.02 ENST00000425929.6
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr12_-_31792290 0.02 ENST00000340398.5
H3-5
H3.5 histone
chr15_-_63156774 0.02 ENST00000462430.5
RPS27L
ribosomal protein S27 like
chrX_+_15749848 0.02 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B
chrX_-_19970298 0.02 ENST00000379687.7
ENST00000379682.8
BCLAF3
BCLAF1 and THRAP3 family member 3
chr7_-_80512041 0.02 ENST00000398291.4
GNAT3
G protein subunit alpha transducin 3
chr14_-_23155302 0.02 ENST00000529705.6
SLC7A8
solute carrier family 7 member 8
chr4_+_112637456 0.02 ENST00000505034.5
ENST00000324052.10
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr12_+_5432101 0.01 ENST00000423158.4
NTF3
neurotrophin 3
chr1_+_52842753 0.01 ENST00000371528.2
ZYG11A
zyg-11 family member A, cell cycle regulator
chr20_+_45702030 0.01 ENST00000305479.3
WFDC13
WAP four-disulfide core domain 13
chr12_-_123633604 0.01 ENST00000534960.5
ENST00000424014.7
EIF2B1
eukaryotic translation initiation factor 2B subunit alpha
chr1_-_3650063 0.01 ENST00000419924.2
ENST00000270708.12
WRAP73
WD repeat containing, antisense to TP73
chr3_-_132684685 0.01 ENST00000512094.5
ENST00000632629.1
NPHP3
NPHP3-ACAD11
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr12_-_76068933 0.00 ENST00000552056.5
NAP1L1
nucleosome assembly protein 1 like 1
chr17_-_31314066 0.00 ENST00000577894.1
EVI2B
ecotropic viral integration site 2B
chr4_+_140343443 0.00 ENST00000338517.8
ENST00000394203.7
ENST00000506322.5
SCOC
short coiled-coil protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.4 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.4 GO:0072189 ureter development(GO:0072189)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)