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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ISL1

Z-value: 0.73

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ENSG00000016082.15 ISL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg38_v1_chr5_+_51383394_51383454-0.683.1e-05Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_95025700 3.45 ENST00000309988.9
ENST00000353004.7
ENST00000354078.7
ENST00000349807.3
mal, T cell differentiation protein
chrX_+_136169833 2.53 ENST00000628032.2
four and a half LIM domains 1
chr6_+_31739948 2.17 ENST00000375755.8
ENST00000425703.5
ENST00000375750.9
ENST00000375703.7
ENST00000375740.7
mutS homolog 5
chrX_+_136169624 1.97 ENST00000394153.6
four and a half LIM domains 1
chrX_+_136169664 1.90 ENST00000456445.5
four and a half LIM domains 1
chrX_+_136169891 1.79 ENST00000449474.5
four and a half LIM domains 1
chr1_-_205455954 1.78 ENST00000495594.2
ENST00000629624.2
LEM domain containing 1
bladder cancer associated transcript 1
chr19_-_49640092 1.78 ENST00000246792.4
RAS related
chr11_-_107858777 1.52 ENST00000525815.6
solute carrier family 35 member F2
chr18_+_23949847 1.51 ENST00000588004.1
laminin subunit alpha 3
chrX_-_15664798 1.47 ENST00000380342.4
collectrin, amino acid transport regulator
chr1_-_99766620 1.37 ENST00000646001.2
ferric chelate reductase 1
chr19_+_39196956 1.33 ENST00000339852.5
NCCRP1, F-box associated domain containing
chr2_-_207165923 1.32 ENST00000309446.11
Kruppel like factor 7
chr12_-_30735014 1.30 ENST00000433722.6
caprin family member 2
chr3_-_185821092 1.27 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr10_-_77637902 1.25 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
potassium calcium-activated channel subfamily M alpha 1
chrX_+_136197039 1.21 ENST00000370683.6
four and a half LIM domains 1
chr10_-_77638369 1.18 ENST00000372443.6
potassium calcium-activated channel subfamily M alpha 1
chr2_+_157257687 1.09 ENST00000259056.5
polypeptide N-acetylgalactosaminyltransferase 5
chr12_-_54419259 1.08 ENST00000293379.9
integrin subunit alpha 5
chr6_+_36029082 1.05 ENST00000472333.1
mitogen-activated protein kinase 14
chr13_-_99016034 0.99 ENST00000448493.7
dedicator of cytokinesis 9
chr20_+_61599755 0.99 ENST00000543233.2
cadherin 4
chr9_+_131289685 0.98 ENST00000372264.4
phospholipid phosphatase 7 (inactive)
chr3_+_122055355 0.96 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr8_-_130386864 0.92 ENST00000521426.5
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr22_+_39994926 0.91 ENST00000333407.11
family with sequence similarity 83 member F
chr2_-_189179754 0.90 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr6_-_116829037 0.86 ENST00000368549.7
ENST00000530250.1
ENST00000310357.8
G protein-coupled receptor class C group 6 member A
chr17_-_66229380 0.86 ENST00000205948.11
apolipoprotein H
chr1_-_204166334 0.81 ENST00000272190.9
renin
chr3_+_57890011 0.80 ENST00000494088.6
ENST00000438794.5
sarcolemma associated protein
chr12_-_27971970 0.79 ENST00000395872.5
ENST00000201015.8
parathyroid hormone like hormone
chr17_-_15598618 0.77 ENST00000583965.5
CMT1A duplicated region transcript 1
chr15_-_55249029 0.75 ENST00000566877.5
RAB27A, member RAS oncogene family
chr10_+_133527355 0.75 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
cytochrome P450 family 2 subfamily E member 1
chr2_+_28395511 0.75 ENST00000436647.1
FOS like 2, AP-1 transcription factor subunit
chr18_-_5543988 0.75 ENST00000341928.7
erythrocyte membrane protein band 4.1 like 3
chr15_-_55270280 0.73 ENST00000564609.5
RAB27A, member RAS oncogene family
chr10_-_93482194 0.73 ENST00000358334.9
ENST00000371488.3
myoferlin
chr15_-_55270874 0.71 ENST00000567380.5
ENST00000565972.5
ENST00000569493.5
RAB27A, member RAS oncogene family
chr9_+_128322540 0.70 ENST00000609948.1
ENST00000608951.5
coenzyme Q4
chr6_+_167291329 0.69 ENST00000366829.2
unc-93 homolog A
chr10_-_93482326 0.69 ENST00000359263.9
myoferlin
chr2_+_172860038 0.68 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chr17_-_82840010 0.68 ENST00000269394.4
ENST00000572562.1
zinc finger protein 750
chr12_+_119668109 0.66 ENST00000229328.10
ENST00000630317.1
protein kinase AMP-activated non-catalytic subunit beta 1
chr8_+_69492793 0.65 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
sulfatase 1
chr6_+_167291309 0.65 ENST00000230256.8
unc-93 homolog A
chr2_+_170178136 0.64 ENST00000409044.7
ENST00000408978.9
myosin IIIB
chr12_-_95116967 0.63 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr18_-_5543960 0.62 ENST00000400111.8
erythrocyte membrane protein band 4.1 like 3
chr9_-_110999458 0.61 ENST00000374430.6
lysophosphatidic acid receptor 1
chr4_+_118034480 0.61 ENST00000296499.6
N-deacetylase and N-sulfotransferase 3
chr18_-_5544250 0.60 ENST00000540638.6
ENST00000342933.7
erythrocyte membrane protein band 4.1 like 3
chrX_+_50067576 0.60 ENST00000376108.7
chloride voltage-gated channel 5
chr7_+_151114597 0.60 ENST00000335367.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr17_+_39667964 0.56 ENST00000394246.1
phenylethanolamine N-methyltransferase
chr17_-_59151794 0.56 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr10_-_77637789 0.55 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
potassium calcium-activated channel subfamily M alpha 1
chr6_+_63521738 0.54 ENST00000648894.1
ENST00000639568.2
protein tyrosine phosphatase 4A1
chr14_-_100569780 0.53 ENST00000355173.7
brain enriched guanylate kinase associated
chr3_-_124887353 0.50 ENST00000296181.9
integrin subunit beta 5
chr2_+_167135901 0.49 ENST00000628543.2
xin actin binding repeat containing 2
chr19_+_3506355 0.49 ENST00000652521.1
fizzy and cell division cycle 20 related 1
chr7_-_78489900 0.49 ENST00000636039.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr20_-_50115935 0.48 ENST00000340309.7
ENST00000415862.6
ENST00000371677.7
ubiquitin conjugating enzyme E2 V1
chr3_-_27456743 0.48 ENST00000295736.9
ENST00000428386.5
ENST00000428179.1
solute carrier family 4 member 7
chr6_-_138499487 0.48 ENST00000343505.9
NHS like 1
chr5_+_137867852 0.45 ENST00000421631.6
ENST00000239926.9
myotilin
chr17_+_68525795 0.45 ENST00000592800.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr21_-_46155567 0.45 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
formimidoyltransferase cyclodeaminase
chr14_-_106360320 0.45 ENST00000390615.2
immunoglobulin heavy variable 3-33
chr12_+_92702843 0.44 ENST00000397833.3
pleckstrin homology and RhoGEF domain containing G7
chr4_-_103077282 0.43 ENST00000503230.5
ENST00000503818.1
solute carrier family 9 member B2
chr18_+_616672 0.43 ENST00000338387.11
clusterin like 1
chr17_-_55511434 0.43 ENST00000636752.1
small integral membrane protein 36
chr15_+_80404320 0.43 ENST00000303329.9
ENST00000622346.4
aryl hydrocarbon receptor nuclear translocator 2
chr7_+_130293134 0.42 ENST00000445470.6
ENST00000492072.5
ENST00000222482.10
ENST00000473956.5
ENST00000493259.5
ENST00000486598.1
carboxypeptidase A4
chr7_-_13986439 0.42 ENST00000443608.5
ENST00000438956.5
ETS variant transcription factor 1
chr18_+_616711 0.41 ENST00000579494.1
clusterin like 1
chr11_+_121102666 0.40 ENST00000264037.2
tectorin alpha
chr14_-_59870752 0.40 ENST00000611068.1
ENST00000267484.10
reticulon 1
chr12_+_92702983 0.40 ENST00000344636.6
ENST00000544406.2
pleckstrin homology and RhoGEF domain containing G7
chr8_+_38728186 0.40 ENST00000519416.5
ENST00000520615.5
transforming acidic coiled-coil containing protein 1
chr14_-_106557465 0.40 ENST00000390625.3
immunoglobulin heavy variable 3-49
chr8_-_3409528 0.39 ENST00000335551.11
CUB and Sushi multiple domains 1
chr14_-_36582593 0.39 ENST00000258829.6
NK2 homeobox 8
chr12_-_54384687 0.39 ENST00000550120.1
ENST00000547210.5
ENST00000394313.7
zinc finger protein 385A
chr1_+_161766282 0.38 ENST00000680688.1
activating transcription factor 6
chr11_+_57805541 0.38 ENST00000683201.1
ENST00000683769.1
catenin delta 1
chr10_+_17228215 0.38 ENST00000544301.7
vimentin
chr1_-_94925759 0.38 ENST00000415017.1
ENST00000545882.5
calponin 3
chr10_-_77637721 0.37 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
potassium calcium-activated channel subfamily M alpha 1
chr12_+_21372899 0.37 ENST00000240652.8
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr12_+_45292674 0.37 ENST00000679426.1
ENST00000441606.2
anoctamin 6
chr6_+_168017873 0.37 ENST00000351261.4
ENST00000354419.6
kinesin family member 25
chr19_+_3506251 0.36 ENST00000441788.7
fizzy and cell division cycle 20 related 1
chr21_-_32813695 0.36 ENST00000479548.2
ENST00000490358.5
chromosome 21 open reading frame 62
chr3_+_4680617 0.35 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr1_+_56854764 0.35 ENST00000361249.4
complement C8 alpha chain
chr17_-_42979993 0.35 ENST00000409103.5
ENST00000360221.8
ENST00000454303.1
ENST00000591916.7
ENST00000451885.3
PTGES3L-AARSD1 readthrough
prostaglandin E synthase 3 like
chr14_-_106675544 0.35 ENST00000390632.2
immunoglobulin heavy variable 3-66
chr8_+_26390362 0.35 ENST00000518611.5
BCL2 interacting protein 3 like
chr3_-_33645433 0.34 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
cytoplasmic linker associated protein 2
chr14_-_106538331 0.34 ENST00000390624.3
immunoglobulin heavy variable 3-48
chr6_+_36885848 0.33 ENST00000355190.7
ENST00000373685.1
chromosome 6 open reading frame 89
chr12_-_6375209 0.32 ENST00000360168.7
sodium channel epithelial 1 subunit alpha
chr5_+_137867868 0.32 ENST00000515645.1
myotilin
chr2_-_166149204 0.31 ENST00000635750.1
sodium voltage-gated channel alpha subunit 1
chr22_+_29883158 0.30 ENST00000333027.7
ENST00000401950.7
ENST00000445401.5
ENST00000323630.9
ENST00000351488.7
myotubularin related protein 3
chr6_+_31547560 0.30 ENST00000376148.9
ENST00000376145.8
NFKB inhibitor like 1
chr2_-_166149120 0.30 ENST00000641575.1
ENST00000641603.1
sodium voltage-gated channel alpha subunit 1
chr2_+_218607914 0.29 ENST00000417849.5
phospholipase C delta 4
chrX_+_80420466 0.29 ENST00000308293.5
terminal nucleotidyltransferase 5D
chr4_-_176002332 0.29 ENST00000280187.11
ENST00000512509.5
glycoprotein M6A
chr2_+_172928165 0.28 ENST00000535187.5
Rap guanine nucleotide exchange factor 4
chr12_+_75481204 0.28 ENST00000550491.1
GLI pathogenesis related 1
chr1_+_112674416 0.28 ENST00000413052.6
ENST00000369645.5
Mov10 RISC complex RNA helicase
chr7_-_122702912 0.28 ENST00000447240.1
ENST00000434824.2
ring finger protein 148
chr13_+_102845835 0.27 ENST00000652613.1
ERCC excision repair 5, endonuclease
chr5_+_141370236 0.27 ENST00000576222.2
ENST00000618934.1
protocadherin gamma subfamily B, 3
chr21_-_40847149 0.27 ENST00000400454.6
DS cell adhesion molecule
chr3_+_38265802 0.27 ENST00000311856.9
solute carrier family 22 member 13
chr1_+_156054761 0.27 ENST00000368305.9
ENST00000368304.9
ENST00000368302.3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr6_+_43021606 0.27 ENST00000244496.6
ribosomal RNA processing 36
chr1_-_156248084 0.27 ENST00000652405.1
ENST00000335852.6
ENST00000540423.5
ENST00000612424.4
ENST00000613336.4
ENST00000623241.3
progestin and adipoQ receptor family member 6
chr16_+_55656249 0.26 ENST00000219833.13
ENST00000574918.2
solute carrier family 6 member 2
chr12_-_91180365 0.26 ENST00000547937.5
decorin
chr7_-_44541318 0.26 ENST00000381160.8
NPC1 like intracellular cholesterol transporter 1
chr6_-_136466858 0.26 ENST00000544465.5
microtubule associated protein 7
chr4_+_73404255 0.26 ENST00000621628.4
ENST00000621085.4
ENST00000415165.6
ENST00000295897.9
ENST00000503124.5
ENST00000509063.5
ENST00000401494.7
albumin
chr10_+_27532521 0.26 ENST00000683924.1
RAB18, member RAS oncogene family
chr15_-_55270383 0.25 ENST00000396307.6
RAB27A, member RAS oncogene family
chr16_+_7332839 0.25 ENST00000355637.9
RNA binding fox-1 homolog 1
chr5_+_32710630 0.24 ENST00000326958.5
natriuretic peptide receptor 3
chr1_-_156248038 0.24 ENST00000470198.5
ENST00000292291.10
ENST00000356983.7
progestin and adipoQ receptor family member 6
chr5_+_53560627 0.24 ENST00000296684.10
ENST00000506765.1
NADH:ubiquinone oxidoreductase subunit S4
chr4_+_56436233 0.24 ENST00000512576.3
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr6_-_127900958 0.23 ENST00000434358.3
ENST00000630369.2
ENST00000368248.4
thymocyte selection associated
chr3_+_130560334 0.23 ENST00000358511.10
collagen type VI alpha 6 chain
chr2_-_213151590 0.23 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKAROS family zinc finger 2
chrX_+_21940693 0.23 ENST00000404933.7
ENST00000379404.5
spermine synthase
chr1_-_156248013 0.23 ENST00000368270.2
progestin and adipoQ receptor family member 6
chr12_+_80716906 0.23 ENST00000228644.4
myogenic factor 5
chr3_-_114179052 0.22 ENST00000383673.5
ENST00000295881.9
dopamine receptor D3
chr7_-_44541262 0.21 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1 like intracellular cholesterol transporter 1
chr2_+_225399684 0.20 ENST00000636099.1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_134411854 0.20 ENST00000392580.5
beta-1,3-glucuronyltransferase 1
chr3_-_49029378 0.20 ENST00000442157.2
ENST00000326739.9
ENST00000677010.1
ENST00000678724.1
ENST00000429182.6
inosine monophosphate dehydrogenase 2
chr1_+_197413827 0.20 ENST00000367397.1
ENST00000681519.1
crumbs cell polarity complex component 1
chr7_-_13986498 0.19 ENST00000420159.6
ENST00000399357.7
ENST00000403527.5
ETS variant transcription factor 1
chr11_-_134412234 0.19 ENST00000312527.9
beta-1,3-glucuronyltransferase 1
chr4_+_87832917 0.19 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
matrix extracellular phosphoglycoprotein
chr6_+_42929127 0.18 ENST00000394142.7
canopy FGF signaling regulator 3
chr12_-_52367478 0.18 ENST00000257901.7
keratin 85
chr16_+_55655960 0.18 ENST00000568943.6
solute carrier family 6 member 2
chr12_-_10986912 0.17 ENST00000506868.1
taste 2 receptor member 50
chr11_-_63015804 0.17 ENST00000535878.5
ENST00000545207.5
solute carrier family 22 member 8
chr1_+_248231417 0.17 ENST00000641868.1
olfactory receptor family 2 subfamily M member 4
chr9_-_109119915 0.17 ENST00000374586.8
transmembrane protein 245
chr18_-_13915531 0.17 ENST00000327606.4
melanocortin 2 receptor
chr3_-_100993448 0.16 ENST00000495063.6
ENST00000486770.7
ENST00000530539.2
ABI family member 3 binding protein
chr10_-_18651576 0.16 ENST00000377304.7
NOP2/Sun RNA methyltransferase 6
chr6_-_24719146 0.16 ENST00000378119.9
chromosome 6 open reading frame 62
chr14_-_106269133 0.16 ENST00000390609.3
immunoglobulin heavy variable 3-23
chr2_-_54987578 0.16 ENST00000486085.5
reticulon 4
chrX_+_23908006 0.15 ENST00000379211.8
ENST00000648352.1
chromosome X open reading frame 58
chr15_+_59611776 0.15 ENST00000396065.3
ENST00000560585.5
glucosaminyl (N-acetyl) transferase 3, mucin type
chr4_-_86360071 0.15 ENST00000641677.1
ENST00000639234.1
ENST00000641553.1
ENST00000641826.1
ENST00000641537.1
ENST00000395169.9
ENST00000641408.1
ENST00000638225.1
ENST00000641052.1
mitogen-activated protein kinase 10
chr6_-_110815408 0.15 ENST00000368911.8
cyclin dependent kinase 19
chr2_+_241350087 0.15 ENST00000451310.1
septin 2
chr14_-_106803221 0.14 ENST00000390636.2
immunoglobulin heavy variable 3-73
chr1_-_113887574 0.14 ENST00000393316.8
BCL2 like 15
chr8_-_42377227 0.14 ENST00000220812.3
dickkopf WNT signaling pathway inhibitor 4
chr6_-_110815152 0.14 ENST00000413605.6
cyclin dependent kinase 19
chr1_-_159714581 0.14 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
C-reactive protein
chr15_+_42359454 0.14 ENST00000349748.8
ENST00000318023.11
ENST00000397163.8
calpain 3
chr7_+_93906557 0.14 ENST00000248572.10
ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
G protein subunit gamma transducin 1
chrX_-_30309387 0.13 ENST00000378970.5
nuclear receptor subfamily 0 group B member 1
chr16_+_33009175 0.13 ENST00000565407.2
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr17_+_35587239 0.13 ENST00000621914.4
ENST00000621668.4
ENST00000616681.4
ENST00000612035.4
ENST00000610402.5
ENST00000614600.4
ENST00000590432.5
ENST00000612116.5
adaptor related protein complex 2 subunit beta 1
chr4_+_70195719 0.13 ENST00000683306.1
odontogenic, ameloblast associated
chr5_-_138875290 0.13 ENST00000521094.2
ENST00000274711.7
leucine rich repeat transmembrane neuronal 2
chr3_+_159069252 0.13 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1 readthrough
chr1_+_192575765 0.13 ENST00000469578.2
ENST00000367459.8
regulator of G protein signaling 1
chr12_-_6375556 0.12 ENST00000228916.7
sodium channel epithelial 1 subunit alpha
chr5_+_174045673 0.12 ENST00000303177.8
ENST00000519867.5
neuronal vesicle trafficking associated 2
chr17_-_40867200 0.11 ENST00000647902.1
ENST00000251643.5
keratin 12
chr16_+_55656294 0.11 ENST00000379906.6
solute carrier family 6 member 2
chrX_-_134658450 0.11 ENST00000359237.9
placenta enriched 1
chr1_+_81800368 0.11 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
adhesion G protein-coupled receptor L2
chr2_+_202073282 0.10 ENST00000459709.5
KIAA2012
chr16_+_20763990 0.10 ENST00000289416.10
acyl-CoA synthetase medium chain family member 3
chr2_-_219170023 0.10 ENST00000409878.8
ENST00000455516.6
ENST00000295738.11
solute carrier family 23 member 3
chr8_+_109362453 0.09 ENST00000378402.10
PKHD1 like 1
chr1_-_160285120 0.09 ENST00000368072.10
peroxisomal biogenesis factor 19
chr11_-_63015831 0.09 ENST00000430500.6
ENST00000336232.7
solute carrier family 22 member 8
chr7_+_144070313 0.09 ENST00000641441.1
olfactory receptor family 2 subfamily A member 25

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 1.0 GO:0002668 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.3 0.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 3.4 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.3 3.4 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 2.0 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 2.2 GO:0051026 chiasma assembly(GO:0051026)
0.2 0.6 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.2 0.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 0.9 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.2 1.0 GO:2001184 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.2 0.8 GO:0010193 response to ozone(GO:0010193)
0.1 0.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.1 9.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 0.8 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 0.3 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.1 0.4 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.5 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.3 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.1 1.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.9 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.7 GO:0035878 nail development(GO:0035878)
0.1 0.2 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 1.4 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.1 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.4 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.3 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.3 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 1.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0097475 motor neuron migration(GO:0097475)
0.0 1.3 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.4 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 1.0 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.0 0.5 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0008215 spermine metabolic process(GO:0008215)
0.0 1.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.1 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.6 GO:0051583 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.8 GO:0002076 osteoblast development(GO:0002076)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.3 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.5 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 1.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.3 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 1.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.5 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.0 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.0 GO:0048058 compound eye corneal lens development(GO:0048058)
0.0 0.1 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 1.2 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 0.6 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0043383 negative T cell selection(GO:0043383)
0.0 1.3 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.1 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.7 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.3 GO:0000469 cleavage involved in rRNA processing(GO:0000469)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.5 GO:0005610 laminin-5 complex(GO:0005610)
0.2 2.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 0.5 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.1 2.2 GO:0032300 mismatch repair complex(GO:0032300)
0.1 2.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.5 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.1 GO:0034706 sodium channel complex(GO:0034706)
0.0 4.7 GO:0005901 caveola(GO:0005901)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.3 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 11.8 GO:0005925 focal adhesion(GO:0005925)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 4.4 GO:0045121 membrane raft(GO:0045121)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.4 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.1 0.6 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.1 0.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.9 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 1.0 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 2.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.2 GO:0004639 phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 0.4 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 1.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 0.5 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.4 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.8 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 8.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.0 2.0 GO:0019003 GDP binding(GO:0019003)
0.0 1.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.6 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.2 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.9 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID AURORA A PATHWAY Aurora A signaling
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.7 ST GAQ PATHWAY G alpha q Pathway
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.3 REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 1.5 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME AMYLOIDS Genes involved in Amyloids