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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ISL2

Z-value: 0.45

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.10 ISL2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg38_v1_chr15_+_76336755_763367790.579.2e-04Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_123601815 1.40 ENST00000451215.6
ASB15
ankyrin repeat and SOCS box containing 15
chr7_+_123601836 1.39 ENST00000434204.5
ASB15
ankyrin repeat and SOCS box containing 15
chr9_+_72577939 0.96 ENST00000645773.1
TMC1
transmembrane channel like 1
chr2_-_162152404 0.88 ENST00000375497.3
GCG
glucagon
chr1_-_247760556 0.77 ENST00000641256.1
OR1C1
olfactory receptor family 1 subfamily C member 1
chr5_-_140346596 0.75 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr12_-_95551417 0.73 ENST00000258499.8
USP44
ubiquitin specific peptidase 44
chr11_-_5301946 0.70 ENST00000380224.2
OR51B4
olfactory receptor family 51 subfamily B member 4
chr2_-_162152239 0.61 ENST00000418842.7
GCG
glucagon
chr5_+_90640718 0.60 ENST00000640403.1
ADGRV1
adhesion G protein-coupled receptor V1
chr11_-_28108109 0.57 ENST00000263181.7
KIF18A
kinesin family member 18A
chr9_+_12693327 0.55 ENST00000388918.10
TYRP1
tyrosinase related protein 1
chr12_+_1970772 0.50 ENST00000682544.1
CACNA1C
calcium voltage-gated channel subunit alpha1 C
chr12_+_1970809 0.50 ENST00000683781.1
ENST00000682462.1
CACNA1C
calcium voltage-gated channel subunit alpha1 C
chr11_-_107858777 0.47 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr17_-_3592877 0.46 ENST00000399756.8
TRPV1
transient receptor potential cation channel subfamily V member 1
chr11_-_124320197 0.44 ENST00000624618.2
OR8D2
olfactory receptor family 8 subfamily D member 2
chr6_+_130018565 0.41 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr3_-_142029108 0.40 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr9_+_72577788 0.39 ENST00000645208.2
TMC1
transmembrane channel like 1
chr9_+_72577369 0.39 ENST00000651183.1
TMC1
transmembrane channel like 1
chr14_+_92323154 0.37 ENST00000532405.6
ENST00000676001.1
ENST00000531433.5
SLC24A4
solute carrier family 24 member 4
chr6_-_155455830 0.37 ENST00000159060.3
NOX3
NADPH oxidase 3
chr15_-_82709886 0.37 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
AP3B2
adaptor related protein complex 3 subunit beta 2
chr17_-_8119047 0.36 ENST00000318227.4
ALOXE3
arachidonate lipoxygenase 3
chr4_+_94207596 0.36 ENST00000359052.8
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr10_-_114144599 0.35 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr2_-_10447771 0.35 ENST00000405333.5
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr3_+_63443076 0.35 ENST00000295894.9
SYNPR
synaptoporin
chr9_+_35042213 0.34 ENST00000378745.3
ENST00000312292.6
C9orf131
chromosome 9 open reading frame 131
chr3_+_42979281 0.33 ENST00000488863.5
ENST00000430121.3
GASK1A
golgi associated kinase 1A
chr21_+_38272410 0.33 ENST00000398934.5
ENST00000398930.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr1_-_13056575 0.32 ENST00000436041.6
PRAMEF27
PRAME family member 27
chrX_-_72808210 0.32 ENST00000419795.6
ENST00000458170.1
FAM236D
family with sequence similarity 236 member D
chr20_-_52105644 0.31 ENST00000371523.8
ZFP64
ZFP64 zinc finger protein
chr12_-_95116967 0.30 ENST00000551521.5
FGD6
FYVE, RhoGEF and PH domain containing 6
chr11_-_35360050 0.29 ENST00000644868.1
ENST00000643454.1
ENST00000646080.1
SLC1A2
solute carrier family 1 member 2
chr17_-_8210203 0.28 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr14_-_67412112 0.28 ENST00000216446.9
PLEK2
pleckstrin 2
chr12_-_56741535 0.27 ENST00000647707.1
ENSG00000285625.1
novel protein
chr2_-_135876382 0.24 ENST00000264156.3
MCM6
minichromosome maintenance complex component 6
chr4_-_137532452 0.24 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
PCDH18
protocadherin 18
chr2_-_208146150 0.23 ENST00000260988.5
CRYGB
crystallin gamma B
chr7_-_24757926 0.23 ENST00000342947.9
ENST00000419307.6
GSDME
gasdermin E
chr2_-_165203870 0.22 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr7_-_111392915 0.22 ENST00000450877.5
IMMP2L
inner mitochondrial membrane peptidase subunit 2
chr13_-_46142834 0.21 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr11_+_35186820 0.20 ENST00000531110.6
ENST00000525685.6
CD44
CD44 molecule (Indian blood group)
chr3_+_169911566 0.20 ENST00000428432.6
ENST00000335556.7
SAMD7
sterile alpha motif domain containing 7
chr9_-_21368962 0.19 ENST00000610660.1
IFNA13
interferon alpha 13
chr8_-_124565699 0.19 ENST00000519168.5
MTSS1
MTSS I-BAR domain containing 1
chrX_-_15314543 0.18 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr6_+_151239951 0.18 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr12_+_69825221 0.18 ENST00000552032.7
MYRFL
myelin regulatory factor like
chr12_+_26011713 0.18 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr10_-_29634964 0.18 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr13_+_30422487 0.17 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chrY_-_23694579 0.17 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr12_+_69825273 0.17 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr11_+_5389377 0.16 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr3_-_186544377 0.16 ENST00000307944.6
CRYGS
crystallin gamma S
chr20_+_31514410 0.15 ENST00000335574.10
ENST00000340852.9
ENST00000398174.9
ENST00000466766.2
ENST00000498035.5
ENST00000344042.5
HM13
histocompatibility minor 13
chr12_+_4720395 0.15 ENST00000252318.7
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
chrX_-_101617921 0.15 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr19_-_3557563 0.15 ENST00000389395.7
ENST00000355415.7
MFSD12
major facilitator superfamily domain containing 12
chr7_-_116030735 0.15 ENST00000393485.5
TFEC
transcription factor EC
chrX_+_135309480 0.14 ENST00000635820.1
ETDC
embryonic testis differentiation homolog C
chr21_-_30487436 0.12 ENST00000334055.5
KRTAP19-2
keratin associated protein 19-2
chr4_+_94207845 0.12 ENST00000457823.6
ENST00000354268.9
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr4_+_127781815 0.12 ENST00000508776.5
HSPA4L
heat shock protein family A (Hsp70) member 4 like
chr4_-_121164314 0.12 ENST00000057513.8
TNIP3
TNFAIP3 interacting protein 3
chr10_-_93482326 0.11 ENST00000359263.9
MYOF
myoferlin
chr10_-_93482194 0.11 ENST00000358334.9
ENST00000371488.3
MYOF
myoferlin
chr18_-_3845292 0.11 ENST00000400145.6
DLGAP1
DLG associated protein 1
chr21_-_30492008 0.11 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chrX_-_49073989 0.11 ENST00000376386.3
ENST00000553851.3
PRAF2
PRA1 domain family member 2
chr7_-_116030750 0.11 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr17_-_7404039 0.11 ENST00000576017.1
ENST00000302422.4
TMEM256
transmembrane protein 256
chr4_+_70242583 0.10 ENST00000304954.3
CSN3
casein kappa
chr10_-_49188380 0.10 ENST00000374153.7
ENST00000374148.1
ENST00000374151.7
TMEM273
transmembrane protein 273
chr7_+_16661182 0.10 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr7_-_45111673 0.09 ENST00000461363.1
ENST00000258770.8
ENST00000495078.1
ENST00000494076.5
ENST00000478532.5
ENST00000361278.7
TBRG4
transforming growth factor beta regulator 4
chr4_-_103019634 0.09 ENST00000510559.1
ENST00000296422.12
ENST00000394789.7
SLC9B1
solute carrier family 9 member B1
chr5_+_132873660 0.08 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chrX_-_31266857 0.08 ENST00000378702.8
ENST00000361471.8
DMD
dystrophin
chr2_-_199955464 0.08 ENST00000354611.9
TYW5
tRNA-yW synthesizing protein 5
chr22_-_28711931 0.08 ENST00000434810.5
ENST00000456369.5
CHEK2
checkpoint kinase 2
chr4_-_89835617 0.08 ENST00000611107.1
ENST00000345009.8
ENST00000505199.5
ENST00000502987.5
SNCA
synuclein alpha
chr2_-_169031317 0.08 ENST00000650372.1
ABCB11
ATP binding cassette subfamily B member 11
chr2_+_231056845 0.08 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
PSMD1
proteasome 26S subunit, non-ATPase 1
chr14_+_34993240 0.08 ENST00000677647.1
SRP54
signal recognition particle 54
chr12_+_64404338 0.08 ENST00000332707.10
XPOT
exportin for tRNA
chr15_+_21579912 0.07 ENST00000628444.1
LINC02203
long intergenic non-protein coding RNA 2203
chr19_+_4402615 0.07 ENST00000301280.10
CHAF1A
chromatin assembly factor 1 subunit A
chr1_-_225428813 0.07 ENST00000338179.6
ENST00000425080.1
LBR
lamin B receptor
chr12_-_110499546 0.07 ENST00000552130.6
VPS29
VPS29 retromer complex component
chr10_-_5003850 0.07 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chr19_+_14583076 0.07 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chr3_-_191282383 0.06 ENST00000427544.6
UTS2B
urotensin 2B
chr4_+_25160631 0.06 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS-AS1
PI4K2B
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr9_-_92404559 0.06 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chrY_+_18546691 0.06 ENST00000309834.8
ENST00000307393.3
ENST00000382856.2
HSFY1
heat shock transcription factor Y-linked 1
chr17_+_4807119 0.06 ENST00000263088.11
ENST00000572940.5
PLD2
phospholipase D2
chr1_-_17439657 0.06 ENST00000375436.9
RCC2
regulator of chromosome condensation 2
chr10_+_94762673 0.05 ENST00000480405.2
ENST00000371321.9
CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr19_+_3185911 0.05 ENST00000246117.9
ENST00000588428.5
NCLN
nicalin
chr5_+_111092172 0.05 ENST00000612402.4
WDR36
WD repeat domain 36
chr19_-_45730861 0.05 ENST00000317683.4
FBXO46
F-box protein 46
chrM_+_9207 0.05 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr17_-_64390852 0.05 ENST00000563924.6
PECAM1
platelet and endothelial cell adhesion molecule 1
chr3_-_165078480 0.04 ENST00000264382.8
SI
sucrase-isomaltase
chr4_+_168497044 0.04 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr7_-_87713287 0.04 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr5_-_131165272 0.04 ENST00000675491.1
ENST00000506908.2
HINT1
histidine triad nucleotide binding protein 1
chr3_+_40477107 0.04 ENST00000314686.9
ENST00000447116.6
ENST00000429348.6
ENST00000432264.4
ENST00000456778.5
ZNF619
zinc finger protein 619
chr4_+_168497066 0.04 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr13_+_48976597 0.03 ENST00000541916.5
FNDC3A
fibronectin type III domain containing 3A
chr2_+_233671879 0.03 ENST00000354728.5
UGT1A9
UDP glucuronosyltransferase family 1 member A9
chr11_+_28108248 0.03 ENST00000406787.7
ENST00000403099.5
ENST00000407364.8
METTL15
methyltransferase like 15
chr3_-_169769542 0.03 ENST00000330368.3
ACTRT3
actin related protein T3
chr11_-_93197932 0.03 ENST00000326402.9
SLC36A4
solute carrier family 36 member 4
chr8_-_63026179 0.03 ENST00000677919.1
GGH
gamma-glutamyl hydrolase
chr8_-_115492221 0.03 ENST00000518018.1
TRPS1
transcriptional repressor GATA binding 1
chr19_+_42313298 0.03 ENST00000301204.8
ENST00000673205.1
TMEM145
transmembrane protein 145
chr8_+_69492793 0.03 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr17_+_10697576 0.02 ENST00000379774.5
ADPRM
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr19_-_51417700 0.02 ENST00000529627.1
ENST00000439889.6
SIGLEC10
sialic acid binding Ig like lectin 10
chr9_+_108862255 0.02 ENST00000333999.5
ACTL7A
actin like 7A
chr11_-_95924067 0.02 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
MTMR2
myotubularin related protein 2
chr19_-_51417791 0.02 ENST00000353836.9
SIGLEC10
sialic acid binding Ig like lectin 10
chr5_-_131165231 0.02 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
HINT1
histidine triad nucleotide binding protein 1
chr10_-_126670686 0.02 ENST00000488181.3
C10orf90
chromosome 10 open reading frame 90
chr1_-_178871060 0.02 ENST00000234816.7
ANGPTL1
angiopoietin like 1
chr3_+_134795277 0.02 ENST00000647596.1
EPHB1
EPH receptor B1
chr9_+_69145463 0.01 ENST00000636438.1
TJP2
tight junction protein 2
chr3_+_160225409 0.01 ENST00000326474.5
C3orf80
chromosome 3 open reading frame 80
chrX_+_103585478 0.01 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
TCEAL4
transcription elongation factor A like 4
chr11_-_95923763 0.01 ENST00000497683.6
ENST00000470293.6
ENST00000674968.1
ENST00000484818.6
ENST00000675454.1
ENST00000675981.1
ENST00000674924.1
ENST00000676166.1
ENST00000676440.1
ENST00000675807.1
ENST00000495134.6
ENST00000675196.1
MTMR2
myotubularin related protein 2
chr5_+_154755272 0.01 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr16_+_28553908 0.01 ENST00000317058.8
SGF29
SAGA complex associated factor 29
chr7_-_108240049 0.01 ENST00000379022.8
NRCAM
neuronal cell adhesion molecule
chrX_+_83861126 0.00 ENST00000621735.4
ENST00000329312.5
CYLC1
cylicin 1
chr1_-_21050952 0.00 ENST00000264211.12
EIF4G3
eukaryotic translation initiation factor 4 gamma 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 1.7 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.8 GO:0051541 elastin metabolic process(GO:0051541)
0.1 1.0 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.4 GO:0048840 otolith development(GO:0048840)
0.0 0.6 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.4 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0030035 microspike assembly(GO:0030035)
0.0 0.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.7 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.5 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.4 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.3 GO:0097186 amelogenesis(GO:0097186)
0.0 0.1 GO:0051622 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.4 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 2.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.0 GO:0050904 diapedesis(GO:0050904)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.5 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 0.4 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.1 1.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.0 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 2.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint