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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for KLF1
Z-value: 1.59
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg38_v1_chr19_-_12887188_12887207 | -0.18 | 3.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.3 | GO:0070268 | cornification(GO:0070268) |
| 1.7 | 14.0 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 2.7 | 13.4 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 4.3 | 12.8 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.8 | 9.9 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.5 | 9.2 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.3 | 8.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 7.6 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.3 | 7.3 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.1 | 7.1 | GO:0006939 | smooth muscle contraction(GO:0006939) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 17.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.8 | 13.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 13.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 8.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 7.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 7.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 7.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 7.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.3 | 6.7 | GO:0030056 | hemidesmosome(GO:0030056) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 2.7 | 13.4 | GO:0030395 | lactose binding(GO:0030395) |
| 0.1 | 12.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.0 | 9.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 8.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 7.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 7.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 7.5 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.7 | 7.3 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 7.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 14.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 13.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 8.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 7.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 6.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 6.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 5.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 5.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.6 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 6.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 5.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 5.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 5.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 5.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.5 | REACTOME ACYL CHAIN REMODELLING OF PC | Genes involved in Acyl chain remodelling of PC |
| 0.1 | 4.3 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 4.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |