ISMARA results: KLF12

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for KLF12

Z-value: 1.01

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Transcription factors associated with KLF12

Gene Symbol	Gene ID	Gene Info
KLF12 Ensembl NCBI GeneCards UniProt	ENSG00000118922.18	KLF12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF12	hg38_v1_chr13_-_74133892_74133941	-0.11	5.7e-01	Click!

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

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Promoter	Score	Transcript	Gene	Gene Info
chr2_+_233195433 Show fit	2.51	ENST00000417661.1	INPP5D Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase D
chr15_-_89496574 Show fit	2.14	ENST00000268122.9	RHCG Ensembl NCBI GeneCards UniProt Show fit	Rh family C glycoprotein
chr1_-_47190013 Show fit	2.01	ENST00000294338.7	PDZK1IP1 Ensembl NCBI GeneCards UniProt Show fit	PDZK1 interacting protein 1
chr2_+_24049673 Show fit	1.75	ENST00000380991.8	FKBP1B Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 1B
chr2_+_24049705 Show fit	1.71	ENST00000380986.9 ENST00000452109.1	FKBP1B Ensembl NCBI GeneCards UniProt Show fit	FKBP prolyl isomerase 1B
chrX_-_48467470 Show fit	1.71	ENST00000619100.4 ENST00000622196.4	SLC38A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 38 member 5
chr17_-_78903193 Show fit	1.60	ENST00000322630.3 ENST00000586713.5	CEP295NL Ensembl NCBI GeneCards UniProt Show fit	CEP295 N-terminal like
chr16_+_69105636 Show fit	1.53	ENST00000569188.6	HAS3 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan synthase 3
chr17_+_1762052 Show fit	1.34	ENST00000254722.9 ENST00000576406.5 ENST00000571149.5	SERPINF1 Ensembl NCBI GeneCards UniProt Show fit	serpin family F member 1
chr17_+_7307531 Show fit	1.32	ENST00000576930.5	EIF5A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 5A

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	4.6	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3	3.5	GO:0048680	positive regulation of axon regeneration(GO:0048680)
0.1	2.7	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.6	2.5	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1	2.2	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
0.7	2.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.5	2.0	GO:0046379	extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1	2.0	GO:0034380	high-density lipoprotein particle assembly(GO:0034380)
0.1	1.6	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.1	1.5	GO:0061370	testosterone biosynthetic process(GO:0061370)

Showing 1 to 10 of 168 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.0	GO:0045121	membrane raft(GO:0045121)
0.0	5.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.3	4.6	GO:0005642	annulate lamellae(GO:0005642)
0.1	4.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	2.3	GO:0005604	basement membrane(GO:0005604)
0.7	2.0	GO:0036117	hyaluranon cable(GO:0036117)
0.0	1.9	GO:0044291	cell-cell contact zone(GO:0044291)
0.1	1.3	GO:0043203	axon hillock(GO:0043203)
0.1	1.2	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1	1.2	GO:0070449	elongin complex(GO:0070449)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.6	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	3.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.7	3.5	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1	2.6	GO:0071949	FAD binding(GO:0071949)
0.4	2.5	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.2	2.4	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	2.3	GO:0030506	ankyrin binding(GO:0030506)
0.0	2.2	GO:0005080	protein kinase C binding(GO:0005080)
0.0	2.1	GO:0003743	translation initiation factor activity(GO:0003743)
0.4	2.0	GO:0050501	hyaluronan synthase activity(GO:0050501)

Showing 1 to 10 of 95 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	2.3	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	1.5	PID CDC42 PATHWAY	CDC42 signaling events
0.0	1.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.9	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.7	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.6	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.6	PID IGF1 PATHWAY	IGF1 pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1	2.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	2.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.0	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	1.7	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	1.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.6	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	1.5	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	1.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 37 entries

Results for KLF12

Z-value: 1.01

Motif logo

Transcription factors associated with KLF12

Activity-expression correlation:

Activity profile of KLF12 motif

Sorted Z-values of KLF12 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF12

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: