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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for KLF16_SP2
Z-value: 1.39
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF16 | hg38_v1_chr19_-_1863497_1863587 | -0.63 | 1.9e-04 | Click! |
| SP2 | hg38_v1_chr17_+_47896150_47896262 | 0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_158587773 Show fit | 11.33 |
ENST00000389413.7
ENST00000409483.5 ENST00000389418.9 |
protein tyrosine phosphatase receptor type N2 |
|
| chr16_+_67431112 Show fit | 11.15 |
ENST00000326152.6
|
hydroxysteroid 11-beta dehydrogenase 2 |
|
| chr7_-_158587710 Show fit | 10.40 |
ENST00000389416.8
|
protein tyrosine phosphatase receptor type N2 |
|
| chr19_+_4639505 Show fit | 9.84 |
ENST00000327473.9
|
TNF alpha induced protein 8 like 1 |
|
| chr16_-_67393486 Show fit | 8.21 |
ENST00000562206.1
ENST00000393957.7 ENST00000290942.9 |
tubulin polymerization promoting protein family member 3 |
|
| chr5_-_7851111 Show fit | 8.10 |
ENST00000399810.7
|
chromosome 5 open reading frame 49 |
|
| chr2_+_119431846 Show fit | 7.18 |
ENST00000306406.5
|
transmembrane protein 37 |
|
| chr6_+_43645011 Show fit | 6.91 |
ENST00000372163.5
ENST00000372165.8 |
radial spoke head component 9 |
|
| chr7_-_123534559 Show fit | 6.82 |
ENST00000324698.11
|
IQ motif and ubiquitin domain containing |
|
| chr11_+_61508742 Show fit | 6.81 |
ENST00000378075.4
|
leucine rich repeat containing 10B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 51.1 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.6 | 30.4 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.8 | 17.3 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.4 | 13.3 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.7 | 12.8 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.6 | 12.8 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 1.1 | 12.2 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.2 | 11.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 1.4 | 10.0 | GO:0018211 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.2 | 9.8 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.8 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.2 | 29.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.8 | 26.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.5 | 23.8 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.6 | 16.7 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.2 | 14.8 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 12.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.7 | 11.5 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 11.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 10.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.2 | GO:0003677 | DNA binding(GO:0003677) |
| 0.9 | 29.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 11.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 3.7 | 11.2 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 10.7 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 10.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.3 | 9.8 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.4 | 9.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.6 | 9.1 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.4 | 9.1 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 9.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 9.3 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 8.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 7.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 7.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 7.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 7.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 6.4 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 16.2 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 10.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.5 | 9.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 9.1 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 8.6 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 7.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 6.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 6.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 6.1 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |