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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for KLF3
Z-value: 1.16
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Transcription factors associated with KLF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF3 | hg38_v1_chr4_+_38664189_38664206 | 0.14 | 4.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_16084002 Show fit | 8.15 |
ENST00000447510.7
|
prominin 1 |
|
| chr12_+_6904733 Show fit | 8.00 |
ENST00000007969.12
ENST00000622489.4 ENST00000443597.7 ENST00000323702.9 |
leucine rich repeat containing 23 |
|
| chr22_-_50532077 Show fit | 5.74 |
ENST00000428989.3
ENST00000403326.5 |
outer dense fiber of sperm tails 3B |
|
| chr21_-_34511317 Show fit | 5.44 |
ENST00000611936.1
ENST00000337385.7 |
potassium voltage-gated channel subfamily E regulatory subunit 1 |
|
| chr22_-_50532137 Show fit | 4.64 |
ENST00000405135.5
ENST00000401779.5 ENST00000682240.1 |
outer dense fiber of sperm tails 3B |
|
| chr3_-_197959977 Show fit | 4.24 |
ENST00000265239.11
|
IQ motif containing G |
|
| chr16_+_84175933 Show fit | 3.85 |
ENST00000569735.1
|
dynein axonemal assembly factor 1 |
|
| chr3_+_49412203 Show fit | 3.46 |
ENST00000273590.3
|
T cell leukemia translocation altered |
|
| chr1_-_60073733 Show fit | 3.18 |
ENST00000450089.6
|
chromosome 1 open reading frame 87 |
|
| chr1_-_60073750 Show fit | 3.13 |
ENST00000371201.3
|
chromosome 1 open reading frame 87 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.1 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 1.2 | 8.2 | GO:2000768 | positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 1.1 | 5.4 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.3 | 4.7 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.6 | 4.6 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.1 | 4.6 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.7 | 4.5 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.7 | 3.5 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 3.4 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 3.2 | GO:0007258 | JUN phosphorylation(GO:0007258) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 7.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 7.3 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.2 | 5.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 5.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 5.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.2 | 4.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.6 | 4.2 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 4.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 2.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.7 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.1 | 8.6 | GO:0042805 | actinin binding(GO:0042805) |
| 0.8 | 5.8 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.1 | 4.6 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 4.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 4.0 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.1 | 3.3 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.2 | 3.2 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 2.7 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 2.7 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.2 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 1.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 3.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 2.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 2.3 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.1 | 2.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 1.7 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.6 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |